| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cobimetinib perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cobimetinib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MBNL2 | muscleblind-like splicing regulator 2 | 0.131898 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.131647 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.124582 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0659696 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0596875 |
| ATP10B | ATPase, class V, type 10B | 0.0538383 |
| MUC13 | mucin 13, cell surface associated | 0.0532174 |
| CANX | calnexin | 0.0506025 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0504109 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0467683 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0436426 |
| PRELID2 | PRELI domain containing 2 | 0.0415268 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0403097 |
| RNF43 | ring finger protein 43 | 0.0399147 |
| SEC24D | SEC24 family member D | 0.0394306 |
| NDRG1 | N-myc downstream regulated 1 | 0.0384229 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0376944 |
| PHF3 | PHD finger protein 3 | 0.0371042 |
| UBL3 | ubiquitin-like 3 | 0.0366258 |
| IFNGR1 | interferon gamma receptor 1 | 0.0364872 |
| NEBL | nebulette | 0.0357819 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0354431 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0342552 |
| HDLBP | high density lipoprotein binding protein | 0.0341762 |
| MXI1 | MAX interactor 1, dimerization protein | 0.033655 |
| EHF | ets homologous factor | 0.0327697 |
| PTEN | phosphatase and tensin homolog | 0.0326323 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0324265 |
| RASSF6 | Ras association (RalGDS/AF-6) domain family member 6 | 0.0322817 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0317871 |
| PGK1 | phosphoglycerate kinase 1 | 0.0306602 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0305421 |
| UBC | ubiquitin C | 0.030485 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0304657 |
| PDZD8 | PDZ domain containing 8 | 0.030424 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0301767 |
| DSPP | dentin sialophosphoprotein | 0.0295413 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0293096 |
| DENND4C | DENN/MADD domain containing 4C | 0.0286191 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0285352 |
| TC2N | tandem C2 domains, nuclear | 0.0284417 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0278775 |
| USP12 | ubiquitin specific peptidase 12 | 0.0278574 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0268822 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0266908 |
| DST | dystonin | 0.0266001 |
| AHNAK | AHNAK nucleoprotein | 0.0262176 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0260037 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.0257195 |
| CALR | calreticulin | 0.0253785 |
| ARRDC3 | arrestin domain containing 3 | 0.0250872 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0249809 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0240813 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0240555 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0239785 |
| OGA | O-GlcNAcase | 0.0237199 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0234151 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.0231911 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0231113 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0230192 |
| GOLGB1 | golgin B1 | 0.0228457 |
| NUCB2 | nucleobindin 2 | 0.0228039 |
| H1-0 | H1.0 linker histone | 0.0227045 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0225391 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.022347 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0219071 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0214102 |
| TRIM2 | tripartite motif containing 2 | 0.0213542 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0212223 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0212189 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0210925 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0209637 |
| SSR1 | signal sequence receptor, alpha | 0.0209318 |
| USP3 | ubiquitin specific peptidase 3 | 0.0204987 |
| GOLGA4 | golgin A4 | 0.0204114 |
| COG6 | component of oligomeric golgi complex 6 | 0.0202694 |
| EPCAM | epithelial cell adhesion molecule | 0.0202521 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.020148 |
| PRRC1 | proline-rich coiled-coil 1 | 0.0199889 |
| AGR2 | anterior gradient 2 | 0.0199834 |
| TRAM1 | translocation associated membrane protein 1 | 0.0199353 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0198604 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0198203 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.019266 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0189911 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0188906 |
| CEP350 | centrosomal protein 350kDa | 0.0188296 |
| RRBP1 | ribosome binding protein 1 | 0.018657 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.0185479 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0185069 |
| B2M | beta-2-microglobulin | 0.0184577 |
| SACK1B | scaffolding CK1 anchoring protein B | 0.0180963 |
| TSPAN8 | tetraspanin 8 | 0.0178882 |
| TMEM165 | transmembrane protein 165 | 0.0178298 |
| DMBT1 | deleted in malignant brain tumors 1 | 0.0177632 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0176506 |
| HYOU1 | hypoxia up-regulated 1 | 0.017471 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0174594 |
| GOLGA2 | golgin A2 | 0.0173756 |
| CLINT1 | clathrin interactor 1 | 0.0173323 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.200896 |
| VCL | vinculin | -0.160864 |
| EGR1 | early growth response 1 | -0.147264 |
| ANXA2 | annexin A2 | -0.146191 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -0.14264 |
| INTS6 | integrator complex subunit 6 | -0.115918 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.113477 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.110021 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.108606 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.101367 |
| PRKCA | protein kinase C, alpha | -0.10037 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0976204 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0863688 |
| RNF213 | ring finger protein 213 | -0.0822993 |
| RIGI | RNA sensor RIG-I | -0.0820166 |
| ITGA6 | integrin, alpha 6 | -0.0816444 |
| AREG | amphiregulin | -0.0806911 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0805261 |
| ATP11A | ATPase, class VI, type 11A | -0.0799503 |
| VMP1 | vacuole membrane protein 1 | -0.0741501 |
| SMAD3 | SMAD family member 3 | -0.0717641 |
| ERBIN | erbb2 interacting protein | -0.07111 |
| EFNB2 | ephrin-B2 | -0.0690857 |
| LYZ | lysozyme | -0.067609 |
| TJP1 | tight junction protein 1 | -0.0663149 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0657671 |
| EZR | ezrin | -0.0653349 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0647565 |
| PLSCR1 | phospholipid scramblase 1 | -0.063768 |
| SP100 | SP100 nuclear antigen | -0.0631954 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0631359 |
| MSI2 | musashi RNA-binding protein 2 | -0.0629593 |
| TNS4 | tensin 4 | -0.0619004 |
| LMO7 | LIM domain 7 | -0.0610067 |
| MX1 | MX dynamin-like GTPase 1 | -0.0607274 |
| EPHB2 | EPH receptor B2 | -0.060402 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.060236 |
| PKM | pyruvate kinase, muscle | -0.0578471 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0577035 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0565021 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0557272 |
| LCN2 | lipocalin 2 | -0.0552101 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0550818 |
| CCNL1 | cyclin L1 | -0.0541997 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0540778 |
| ASPH | aspartate beta-hydroxylase | -0.0539067 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0530659 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0529253 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0526597 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.052205 |
| MAP7 | microtubule-associated protein 7 | -0.0516606 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0512706 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0512447 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0493784 |
| BCL2L1 | BCL2-like 1 | -0.0481602 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0476278 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.047287 |
| MCL1 | myeloid cell leukemia 1 | -0.0434931 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0432726 |
| NF1 | neurofibromin 1 | -0.0426784 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0420147 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0412657 |
| POTEF | POTE ankyrin domain family, member F | -0.0408406 |
| IRS2 | insulin receptor substrate 2 | -0.0402548 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0390591 |
| MYO1E | myosin IE | -0.0390351 |
| TM4SF19 | transmembrane 4 L six family member 19 | -0.0387259 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0384835 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0368793 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0362693 |
| UBAP2 | ubiquitin associated protein 2 | -0.035951 |
| SPATA13 | spermatogenesis associated 13 | -0.0358677 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.035526 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0352084 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0346623 |
| MX2 | MX dynamin-like GTPase 2 | -0.0346072 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0341044 |
| DIAPH1 | diaphanous-related formin 1 | -0.0338009 |
| RAD51B | RAD51 paralog B | -0.0335733 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | -0.0335541 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0334559 |
| CTBP2 | C-terminal binding protein 2 | -0.0328685 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0328516 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | -0.0327087 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0326105 |
| FOSL1 | FOS-like antigen 1 | -0.0326012 |
| PMP22 | peripheral myelin protein 22 | -0.032025 |
| JUN | jun proto-oncogene | -0.0315992 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0315427 |
| NABP1 | nucleic acid binding protein 1 | -0.0311307 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0304745 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0304531 |
| LAMA4 | laminin, alpha 4 | -0.0301494 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0299931 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | -0.02989 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0295924 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0295467 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0293684 |
| PADI1 | peptidyl arginine deiminase, type I | -0.0293272 |
| PTK2 | protein tyrosine kinase 2 | -0.0290655 |
