Cobimetinib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cobimetinib perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cobimetinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0764532
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0740866
TIMP3 TIMP metallopeptidase inhibitor 3 0.0601083
FTL ferritin, light polypeptide 0.0583064
MT2A metallothionein 2A 0.0564661
RPS6 ribosomal protein S6 0.0403609
B2M beta-2-microglobulin 0.0400132
ENO1 enolase 1, (alpha) 0.037737
DPYSL3 dihydropyrimidinase-like 3 0.0370804
TGFBI transforming growth factor, beta-induced, 68kDa 0.0353482
SOD2 superoxide dismutase 2, mitochondrial 0.0335653
RPS8 ribosomal protein S8 0.0330619
RPL35A ribosomal protein L35a 0.0318941
IFI6 interferon, alpha-inducible protein 6 0.0308151
EIF1 eukaryotic translation initiation factor 1 0.0299358
TMSB10 thymosin beta 10 0.0285017
CADM1 cell adhesion molecule 1 0.0263075
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0250464
PTMA prothymosin, alpha 0.0243143
RPS19 ribosomal protein S19 0.0242609
ADM adrenomedullin 0.0238784
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0238475
CCDC80 coiled-coil domain containing 80 0.0233699
FBXO32 F-box protein 32 0.0232765
CSF1 colony stimulating factor 1 (macrophage) 0.0232285
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0226067
GBP1 guanylate binding protein 1, interferon-inducible 0.0222495
SAMD9 sterile alpha motif domain containing 9 0.0217417
LGALS1 lectin, galactoside-binding, soluble, 1 0.0204856
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0203745
RPL11 ribosomal protein L11 0.0202809
RPS3 ribosomal protein S3 0.0198828
RPS12 ribosomal protein S12 0.0195389
CFB complement factor B 0.0195276
ACTG1 actin gamma 1 0.0192283
RPL37A ribosomal protein L37a 0.0191825
RPL23 ribosomal protein L23 0.0188246
IDO1 indoleamine 2,3-dioxygenase 1 0.0183145
IFITM3 interferon induced transmembrane protein 3 0.0182483
RPL8 ribosomal protein L8 0.0182261
RPLP1 ribosomal protein, large, P1 0.0175107
ISG15 ISG15 ubiquitin-like modifier 0.0172144
RNF220 ring finger protein 220 0.01688
DDIT4 DNA-damage-inducible transcript 4 0.0167213
RPL18 ribosomal protein L18 0.0166748
RPL36 ribosomal protein L36 0.0166525
LIMCH1 LIM and calponin homology domains 1 0.0165633
S100A9 S100 calcium binding protein A9 0.0158652
INSIG1 insulin induced gene 1 0.0155878
WSB1 WD repeat and SOCS box containing 1 0.0150381
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0150276
RPL19 ribosomal protein L19 0.0147329
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0144893
FAM162A family with sequence similarity 162, member A 0.0144749
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0144089
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0142764
RPS14 ribosomal protein S14 0.0142198
RPL12 ribosomal protein L12 0.0141237
GBP2 guanylate binding protein 2, interferon-inducible 0.0138851
ARRDC3 arrestin domain containing 3 0.0136973
RPLP2 ribosomal protein, large, P2 0.01353
ZNF292 zinc finger protein 292 0.0134909
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0132921
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0132424
HSPB1 heat shock 27kDa protein 1 0.013202
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0131825
RPS17 ribosomal protein S17 0.0131659
CCN4 cellular communication network factor 4 0.0130216
MX2 MX dynamin-like GTPase 2 0.0129421
BHLHE40 basic helix-loop-helix family, member e40 0.0128169
RPL26 ribosomal protein L26 0.012791
RPL37 ribosomal protein L37 0.0124545
DCLK1 doublecortin-like kinase 1 0.0124445
PRUNE2 prune homolog 2 (Drosophila) 0.0123798
RACK1 receptor for activated C kinase 1 0.0123784
RPS15 ribosomal protein S15 0.0122879
VIM vimentin 0.0122332
TMEM123 transmembrane protein 123 0.0122114
NFE2L1 nuclear factor, erythroid 2-like 1 0.0122105
RPL9 ribosomal protein L9 0.0120653
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0117875
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0115801
RPS29 ribosomal protein S29 0.0115801
PFN1 profilin 1 0.0114176
MX1 MX dynamin-like GTPase 1 0.0113848
AHR aryl hydrocarbon receptor 0.0112757
SEPTIN7 septin 7 0.0110081
RPS5 ribosomal protein S5 0.0109934
SQSTM1 sequestosome 1 0.0109804
WARS1 tryptophanyl-tRNA synthetase 1 0.0108463
RPL28 ribosomal protein L28 0.0106559
TKT transketolase 0.0105889
IFIH1 interferon induced with helicase C domain 1 0.0104506
COX6C cytochrome c oxidase subunit VIc 0.0103176
RAB6A RAB6A, member RAS oncogene family 0.0103071
RARB retinoic acid receptor, beta 0.0102985
RPL30 ribosomal protein L30 0.010243
HDAC9 histone deacetylase 9 0.0102137
RPS27 ribosomal protein S27 0.0101924
IFI30 interferon, gamma-inducible protein 30 0.0101459

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.279969
FN1 fibronectin 1 -0.258229
COL6A3 collagen, type VI, alpha 3 -0.173575
CDH13 cadherin 13 -0.154717
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0979139
CD44 CD44 molecule (Indian blood group) -0.0951257
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.084827
EXT1 exostosin glycosyltransferase 1 -0.0846565
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0840355
HMGA2 high mobility group AT-hook 2 -0.0757223
STC1 stanniocalcin 1 -0.0727196
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.069166
FBN1 fibrillin 1 -0.0598964
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0546702
VCAN versican -0.0542204
ASPH aspartate beta-hydroxylase -0.0532457
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0531566
WWTR1 WW domain containing transcription regulator 1 -0.053012
GLIS3 GLIS family zinc finger 3 -0.0508622
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0463015
COL5A1 collagen, type V, alpha 1 -0.0455119
PTK2 protein tyrosine kinase 2 -0.0425576
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0412112
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0408046
COL1A2 collagen, type I, alpha 2 -0.0406529
NALF1 NALCN channel auxiliary factor 1 -0.0388281
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0364088
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0363408
VEGFA vascular endothelial growth factor A -0.0362842
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0360036
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0358686
MYH9 myosin, heavy chain 9, non-muscle -0.0356096
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0355876
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0344617
LOX lysyl oxidase -0.0329319
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0327524
PDE10A phosphodiesterase 10A -0.0327336
F3 coagulation factor III (thromboplastin, tissue factor) -0.0323796
IL6ST interleukin 6 signal transducer -0.0317936
JARID2 jumonji, AT rich interactive domain 2 -0.0311621
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0309734
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0308374
DOCK5 dedicator of cytokinesis 5 -0.0302422
ANTXR2 anthrax toxin receptor 2 -0.0298815
EFNA5 ephrin-A5 -0.0298578
ZBTB38 zinc finger and BTB domain containing 38 -0.02957
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.029165
ECE1 endothelin converting enzyme 1 -0.029013
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0286416
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0284826
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0283192
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0283187
NAV1 neuron navigator 1 -0.0280395
FNDC3B fibronectin type III domain containing 3B -0.0276692
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0264653
CLMP CXADR-like membrane protein -0.0257232
AHNAK AHNAK nucleoprotein -0.0255481
GOLGB1 golgin B1 -0.0253196
TRPS1 trichorhinophalangeal syndrome I -0.0251268
DPYD dihydropyrimidine dehydrogenase -0.0250476
MYO10 myosin X -0.0250002
LOXL2 lysyl oxidase-like 2 -0.0238988
MACF1 microtubule-actin crosslinking factor 1 -0.0238458
TM4SF1 transmembrane 4 L six family member 1 -0.0237927
ATP13A3 ATPase type 13A3 -0.0233851
COL6A1 collagen, type VI, alpha 1 -0.0233614
RUNX1 runt-related transcription factor 1 -0.0231887
GRB10 growth factor receptor-bound protein 10 -0.0230751
INHBA inhibin, beta A -0.022094
ELL2 elongation factor, RNA polymerase II, 2 -0.0220353
CANX calnexin -0.0218157
EGR1 early growth response 1 -0.0214726
PLEC plectin -0.0212431
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0211892
COL7A1 collagen, type VII, alpha 1 -0.0211521
RASA2 RAS p21 protein activator 2 -0.0211238
IL6 interleukin 6 -0.0207714
CALR calreticulin -0.0201262
COL1A1 collagen, type I, alpha 1 -0.0196889
PALM2AKAP2 PALM2 and AKAP2 fusion -0.019627
OSMR oncostatin M receptor -0.0194339
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0193817
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0193509
SDC2 syndecan 2 -0.0190084
HDLBP high density lipoprotein binding protein -0.0187834
VCL vinculin -0.0185775
MTSS1 metastasis suppressor 1 -0.0183174
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0182999
ZFAND3 zinc finger, AN1-type domain 3 -0.0181528
NRP1 neuropilin 1 -0.0178442
ANKH ANKH inorganic pyrophosphate transport regulator -0.0177828
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0176085
ZEB1 zinc finger E-box binding homeobox 1 -0.0175921
APP amyloid beta (A4) precursor protein -0.0174661
FAT1 FAT atypical cadherin 1 -0.0172929
PICALM phosphatidylinositol binding clathrin assembly protein -0.0172367
LTBP1 latent transforming growth factor beta binding protein 1 -0.0168573
ARHGAP22 Rho GTPase activating protein 22 -0.0165097
HIPK2 homeodomain interacting protein kinase 2 -0.0164525
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0162789