| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cobimetinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cobimetinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS6 | ribosomal protein S6 | 0.104282 |
| RPS12 | ribosomal protein S12 | 0.1016 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.101005 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0814424 |
| TF | transferrin | 0.0738051 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0736146 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0727357 |
| RPL37A | ribosomal protein L37a | 0.0653126 |
| FTL | ferritin, light polypeptide | 0.0619348 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0618422 |
| ENO1 | enolase 1, (alpha) | 0.0586613 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.052783 |
| CFB | complement factor B | 0.0527415 |
| RPS8 | ribosomal protein S8 | 0.0501806 |
| RPS3 | ribosomal protein S3 | 0.0491934 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0477162 |
| RPL12 | ribosomal protein L12 | 0.047193 |
| IGF2 | insulin-like growth factor 2 | 0.0469266 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0466159 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0435421 |
| APOA2 | apolipoprotein A-II | 0.0429551 |
| RPS19 | ribosomal protein S19 | 0.0421911 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0417961 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0402203 |
| APOE | apolipoprotein E | 0.0402044 |
| ZNF292 | zinc finger protein 292 | 0.0401433 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0386358 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0385083 |
| APOA1 | apolipoprotein A-I | 0.0384346 |
| PEG10 | paternally expressed 10 | 0.0377054 |
| FGG | fibrinogen gamma chain | 0.0361811 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0356714 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0354821 |
| RPL23 | ribosomal protein L23 | 0.035303 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0350404 |
| DTNA | dystrobrevin, alpha | 0.0347515 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0344218 |
| FHIT | fragile histidine triad | 0.0340164 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0337581 |
| RPL9 | ribosomal protein L9 | 0.0327438 |
| EFNA1 | ephrin-A1 | 0.0327226 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0323976 |
| AHSG | alpha-2-HS-glycoprotein | 0.0319046 |
| RPS2 | ribosomal protein S2 | 0.0316927 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.03136 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0313507 |
| FABP1 | fatty acid binding protein 1, liver | 0.0310083 |
| RPS17 | ribosomal protein S17 | 0.0308593 |
| RACK1 | receptor for activated C kinase 1 | 0.0297346 |
| PPP4R2 | protein phosphatase 4, regulatory subunit 2 | 0.0287495 |
| FGA | fibrinogen alpha chain | 0.0285695 |
| RPL34 | ribosomal protein L34 | 0.0280063 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0277498 |
| FGB | fibrinogen beta chain | 0.027745 |
| PRELID2 | PRELI domain containing 2 | 0.0275604 |
| RPL35A | ribosomal protein L35a | 0.0272077 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0271181 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0267669 |
| RPL11 | ribosomal protein L11 | 0.0266665 |
| RPS29 | ribosomal protein S29 | 0.0266033 |
| RPL36 | ribosomal protein L36 | 0.0264976 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0261963 |
| RPL5 | ribosomal protein L5 | 0.0257267 |
| RPL26 | ribosomal protein L26 | 0.0254911 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0252811 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0251065 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0250658 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0249984 |
| RPS5 | ribosomal protein S5 | 0.0248296 |
| HELZ | helicase with zinc finger | 0.0247593 |
| RAD51B | RAD51 paralog B | 0.0247146 |
| GABBR1 | gamma-aminobutyric acid (GABA) B receptor, 1 | 0.0244251 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0242892 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0242462 |
| RPL7 | ribosomal protein L7 | 0.0238352 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0238272 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.02367 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.02351 |
| B2M | beta-2-microglobulin | 0.0227789 |
| WWOX | WW domain containing oxidoreductase | 0.0226637 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0222694 |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.02226 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0218386 |
| RPS23 | ribosomal protein S23 | 0.0217212 |
| RPL30 | ribosomal protein L30 | 0.0215377 |
| RPL36A | ribosomal protein L36a | 0.0214315 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.020951 |
| RPL31 | ribosomal protein L31 | 0.0208608 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.020582 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | 0.0202665 |
| RPL18 | ribosomal protein L18 | 0.0201286 |
| C3 | complement component 3 | 0.0200351 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | 0.019983 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0197543 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.019663 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | 0.0195847 |
| RPS27A | ribosomal protein S27a | 0.0195721 |
| PLIN2 | perilipin 2 | 0.0195019 |
| SET | SET nuclear proto-oncogene | 0.0192559 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0190894 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.168766 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.15089 |
| MT2A | metallothionein 2A | -0.139854 |
| FN1 | fibronectin 1 | -0.138527 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.135169 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.132016 |
| SLC38A2 | solute carrier family 38, member 2 | -0.119222 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.113641 |
| EHBP1 | EH domain binding protein 1 | -0.109607 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.090893 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0790148 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0757683 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0739755 |
| GPC6 | glypican 6 | -0.0732213 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0674355 |
| FRMD5 | FERM domain containing 5 | -0.0645405 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0643507 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0639589 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0603036 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.05875 |
| SVIL | supervillin | -0.0556292 |
| ASPH | aspartate beta-hydroxylase | -0.053795 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0537637 |
| EGR1 | early growth response 1 | -0.0486652 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0482341 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0469906 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.045241 |
| BCL2L1 | BCL2-like 1 | -0.0436582 |
| FMNL2 | formin-like 2 | -0.042555 |
| ITGA1 | integrin, alpha 1 | -0.0420233 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0416242 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0411693 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0404323 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0402645 |
| VCL | vinculin | -0.0402312 |
| FAT1 | FAT atypical cadherin 1 | -0.0400805 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0400783 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0386918 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0382945 |
| MCL1 | myeloid cell leukemia 1 | -0.0378362 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0377139 |
| ITGAV | integrin, alpha V | -0.0368556 |
| VMP1 | vacuole membrane protein 1 | -0.0364072 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.036072 |
| RUNX1 | runt-related transcription factor 1 | -0.0359393 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0356034 |
| FAM107B | family with sequence similarity 107, member B | -0.0346952 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0341557 |
| TMSB10 | thymosin beta 10 | -0.0323643 |
| FAM135A | family with sequence similarity 135, member A | -0.0318007 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0315577 |
| SMAD3 | SMAD family member 3 | -0.0315558 |
| ATP10A | ATPase, class V, type 10A | -0.0310622 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0307003 |
| TXNRD1 | thioredoxin reductase 1 | -0.0305461 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0302395 |
| HMGA1 | high mobility group AT-hook 1 | -0.0296772 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0293585 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0293382 |
| IER3 | immediate early response 3 | -0.028632 |
| ATXN1 | ataxin 1 | -0.0284879 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0283702 |
| FOXP1 | forkhead box P1 | -0.0279833 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0277407 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | -0.0277338 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0276893 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0275731 |
| TPM4 | tropomyosin 4 | -0.0270516 |
| ITGB5 | integrin, beta 5 | -0.0263225 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0259344 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0257355 |
| RAI14 | retinoic acid induced 14 | -0.025554 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0254879 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0254662 |
| STK17A | serine/threonine kinase 17a | -0.0253765 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0253566 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0251392 |
| ARHGAP9 | Rho GTPase activating protein 9 | -0.0249282 |
| MALT1 | MALT1 paracaspase | -0.0243592 |
| PRKCA | protein kinase C, alpha | -0.024348 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0239441 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0238226 |
| DST | dystonin | -0.0238186 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | -0.0237932 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0231675 |
| PHF3 | PHD finger protein 3 | -0.0230321 |
| GK | glycerol kinase | -0.0225839 |
| DUSP6 | dual specificity phosphatase 6 | -0.0225498 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0223647 |
| PEG3 | paternally expressed 3 | -0.0219593 |
| PERP | PERP, TP53 apoptosis effector | -0.021533 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0214376 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0210677 |
| NHSL1 | NHS-like 1 | -0.0210337 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0210299 |
| FILIP1L | filamin A interacting protein 1-like | -0.0208999 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0208917 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0208749 |
| NDRG1 | N-myc downstream regulated 1 | -0.0205999 |
| ANO6 | anoctamin 6 | -0.0205807 |
