| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cobimetinib perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cobimetinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.129705 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.121146 |
| B2M | beta-2-microglobulin | 0.0957029 |
| MEF2A | myocyte enhancer factor 2A | 0.0949626 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0859588 |
| CLU | clusterin | 0.0777379 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0746885 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0724481 |
| RPS3 | ribosomal protein S3 | 0.0717897 |
| SQSTM1 | sequestosome 1 | 0.0709455 |
| ENO1 | enolase 1, (alpha) | 0.0655562 |
| KRT6A | keratin 6A, type II | 0.0654563 |
| KIAA1217 | KIAA1217 | 0.0619056 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.061326 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0580232 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0560674 |
| PLAT | plasminogen activator, tissue | 0.0550049 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0545805 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0543391 |
| RPS12 | ribosomal protein S12 | 0.0540953 |
| RPS8 | ribosomal protein S8 | 0.0498382 |
| RPS2 | ribosomal protein S2 | 0.0491652 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0477728 |
| RPS6 | ribosomal protein S6 | 0.0466107 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0463441 |
| PGK1 | phosphoglycerate kinase 1 | 0.0449491 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.044385 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0441817 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0441471 |
| KRT17 | keratin 17, type I | 0.0421506 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0420516 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0420125 |
| TKT | transketolase | 0.0419867 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0410683 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0392605 |
| IGF2 | insulin-like growth factor 2 | 0.0378491 |
| PTMA | prothymosin, alpha | 0.0375241 |
| EHF | ets homologous factor | 0.0371034 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0370981 |
| MYOF | myoferlin | 0.0363161 |
| GLYAT | glycine-N-acyltransferase | 0.0362585 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0354045 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0349722 |
| FNIP1 | folliculin interacting protein 1 | 0.0348428 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0347255 |
| PLPP1 | phospholipid phosphatase 1 | 0.0334913 |
| ADM | adrenomedullin | 0.0330916 |
| DSCAM | Down syndrome cell adhesion molecule | 0.032978 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0328612 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.032853 |
| IFI44 | interferon-induced protein 44 | 0.0319699 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0319694 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0313843 |
| KIF16B | kinesin family member 16B | 0.0309046 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0306923 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0303944 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.030349 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0302637 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0300016 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0299374 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0299282 |
| RPL37A | ribosomal protein L37a | 0.0299278 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0298701 |
| S100A2 | S100 calcium binding protein A2 | 0.0294278 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0294021 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0293746 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0292322 |
| SET | SET nuclear proto-oncogene | 0.0292152 |
| IFI44L | interferon-induced protein 44-like | 0.0292063 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0290874 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0290327 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.0289333 |
| BZW2 | basic leucine zipper and W2 domains 2 | 0.0289121 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.0288254 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.028625 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0286126 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0285745 |
| CD9 | CD9 molecule | 0.0284922 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0280239 |
| CALD1 | caldesmon 1 | 0.0280006 |
| MXRA5 | matrix-remodelling associated 5 | 0.0279616 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0273078 |
| SAMD9L | sterile alpha motif domain containing 9-like | 0.0271575 |
| ZNF292 | zinc finger protein 292 | 0.0268109 |
| PRELID2 | PRELI domain containing 2 | 0.0267163 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.026648 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0266023 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | 0.0266009 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0265149 |
| SLC45A4 | solute carrier family 45, member 4 | 0.0264338 |
| GBP4 | guanylate binding protein 4 | 0.0263112 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0262873 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0259015 |
| ANXA1 | annexin A1 | 0.0258869 |
| APOL6 | apolipoprotein L, 6 | 0.025807 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0256882 |
| S100A11 | S100 calcium binding protein A11 | 0.0256868 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0250553 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0249932 |
| EXOC4 | exocyst complex component 4 | 0.0246354 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.297407 |
| FLNB | filamin B, beta | -0.159841 |
| STC1 | stanniocalcin 1 | -0.144632 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.123832 |
| NDRG1 | N-myc downstream regulated 1 | -0.111259 |
| CD44 | CD44 molecule (Indian blood group) | -0.105043 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0946865 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0845463 |
| ITGA6 | integrin, alpha 6 | -0.0829772 |
| BCL2L1 | BCL2-like 1 | -0.0733358 |
| MT2A | metallothionein 2A | -0.0724893 |
| TMSB10 | thymosin beta 10 | -0.0662699 |
| OSMR | oncostatin M receptor | -0.0609433 |
| LMO7 | LIM domain 7 | -0.0605793 |
| ASPH | aspartate beta-hydroxylase | -0.0587804 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0586169 |
| DUSP6 | dual specificity phosphatase 6 | -0.0575694 |
| EMP1 | epithelial membrane protein 1 | -0.0568955 |
| MYO10 | myosin X | -0.0565335 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0565156 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.0561568 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0556325 |
| HMGA2 | high mobility group AT-hook 2 | -0.055267 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0522145 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.0521918 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0513292 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0506578 |
| DUSP4 | dual specificity phosphatase 4 | -0.0495936 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0478163 |
| POTEF | POTE ankyrin domain family, member F | -0.0457366 |
| FOSL1 | FOS-like antigen 1 | -0.045127 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0436759 |
| MTSS1 | metastasis suppressor 1 | -0.0424146 |
| CDK6 | cyclin-dependent kinase 6 | -0.0422672 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0419023 |
| SMAD3 | SMAD family member 3 | -0.0404464 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0403333 |
| KIAA0040 | KIAA0040 | -0.040069 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0399749 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0399212 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0396281 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0390252 |
| ACTN1 | actinin, alpha 1 | -0.0388789 |
| EZR | ezrin | -0.0385028 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0385018 |
| CMIP | c-Maf inducing protein | -0.0375411 |
| EPHA2 | EPH receptor A2 | -0.0371887 |
| EGR1 | early growth response 1 | -0.0367385 |
| LUZP1 | leucine zipper protein 1 | -0.0366516 |
| RASAL2 | RAS protein activator like 2 | -0.0364928 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0364561 |
| ITGB4 | integrin, beta 4 | -0.0363523 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.036307 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0356472 |
| TOP1 | topoisomerase (DNA) I | -0.0354962 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0350819 |
| EFNA5 | ephrin-A5 | -0.0348299 |
| SYNJ2 | synaptojanin 2 | -0.0341612 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0340241 |
| PRSS23 | protease, serine, 23 | -0.0339282 |
| FOXP1 | forkhead box P1 | -0.0338999 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0338523 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | -0.0338062 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0336294 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0333053 |
| TNS4 | tensin 4 | -0.0332779 |
| CUL4B | cullin 4B | -0.0320295 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0311914 |
| CSNK1E | casein kinase 1, epsilon | -0.0311824 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0310769 |
| MSN | moesin | -0.0309779 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.0308001 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0307163 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0304941 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0296478 |
| PYGL | phosphorylase, glycogen, liver | -0.0295934 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0288245 |
| CAPRIN2 | caprin family member 2 | -0.0287376 |
| RIN2 | Ras and Rab interactor 2 | -0.0286613 |
| ACER3 | alkaline ceramidase 3 | -0.0286598 |
| HM13 | histocompatibility (minor) 13 | -0.0278049 |
| FAM107B | family with sequence similarity 107, member B | -0.0277874 |
| LRRC8C | leucine rich repeat containing 8 family, member C | -0.0277867 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0277782 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.027248 |
| PCDH1 | protocadherin 1 | -0.0272245 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.027026 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0269625 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0260356 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0257196 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0255313 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0255307 |
| PLEC | plectin | -0.0253576 |
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase | -0.0253485 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0250379 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0248253 |
| CDCP1 | CUB domain containing protein 1 | -0.0248187 |
| TPM4 | tropomyosin 4 | -0.0246217 |
| NAV2 | neuron navigator 2 | -0.0246021 |
| RAI14 | retinoic acid induced 14 | -0.024552 |
