| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cobimetinib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cobimetinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS6 | ribosomal protein S6 | 0.109521 |
| INSIG1 | insulin induced gene 1 | 0.107465 |
| FAM13A | family with sequence similarity 13, member A | 0.0990108 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0837721 |
| RPS12 | ribosomal protein S12 | 0.0810288 |
| MUC13 | mucin 13, cell surface associated | 0.0744706 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0725958 |
| PTMA | prothymosin, alpha | 0.0719044 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0662811 |
| B2M | beta-2-microglobulin | 0.066222 |
| RPL37A | ribosomal protein L37a | 0.0603746 |
| PRELID2 | PRELI domain containing 2 | 0.0586733 |
| FNBP1L | formin binding protein 1-like | 0.0582773 |
| SHROOM3 | shroom family member 3 | 0.0562689 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0555038 |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | 0.052354 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0519928 |
| ZNF292 | zinc finger protein 292 | 0.0519549 |
| RPS3 | ribosomal protein S3 | 0.0500805 |
| RPS2 | ribosomal protein S2 | 0.0478767 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0462902 |
| DENND4C | DENN/MADD domain containing 4C | 0.0462528 |
| RPL12 | ribosomal protein L12 | 0.0449796 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.0419796 |
| RPL34 | ribosomal protein L34 | 0.0415117 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0402582 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0402359 |
| RPS29 | ribosomal protein S29 | 0.0400515 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.039374 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0393603 |
| RPL26 | ribosomal protein L26 | 0.037441 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0374297 |
| FOXP1 | forkhead box P1 | 0.0371729 |
| CDK19 | cyclin-dependent kinase 19 | 0.0365655 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0359828 |
| RPS19 | ribosomal protein S19 | 0.0354933 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0353749 |
| NRXN3 | neurexin 3 | 0.0346469 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.0345107 |
| PDZD8 | PDZ domain containing 8 | 0.0344934 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0343174 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.0342922 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0341872 |
| RPL35A | ribosomal protein L35a | 0.0335533 |
| BBX | bobby sox homolog (Drosophila) | 0.0331379 |
| RPL23 | ribosomal protein L23 | 0.0331295 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0329624 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0325589 |
| RPS8 | ribosomal protein S8 | 0.0325439 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0321675 |
| OGA | O-GlcNAcase | 0.0319534 |
| DNM2 | dynamin 2 | 0.0315182 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | 0.0313701 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | 0.0312408 |
| TPD52 | tumor protein D52 | 0.0309377 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0308812 |
| RPL36 | ribosomal protein L36 | 0.0307209 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0306934 |
| DSPP | dentin sialophosphoprotein | 0.0305893 |
| SYBU | syntabulin (syntaxin-interacting) | 0.0305578 |
| RPS23 | ribosomal protein S23 | 0.0301362 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0300012 |
| RPS27 | ribosomal protein S27 | 0.0297334 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0297261 |
| SNAPC3 | small nuclear RNA activating complex, polypeptide 3, 50kDa | 0.029603 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0295375 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0295342 |
| FRYL | FRY-like | 0.029048 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0287861 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0287719 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0286728 |
| CERS6 | ceramide synthase 6 | 0.0286006 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0285878 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0282399 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0280128 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0275834 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.0272405 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0270287 |
| RPLP1 | ribosomal protein, large, P1 | 0.0269718 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0268042 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.02605 |
| ETV6 | ets variant 6 | 0.0259651 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0259546 |
| EPCAM | epithelial cell adhesion molecule | 0.0258351 |
| GOLGA4 | golgin A4 | 0.0258194 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.025772 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0256369 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0255707 |
| PDE8A | phosphodiesterase 8A | 0.0255223 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0252109 |
| RPL37 | ribosomal protein L37 | 0.0251633 |
| FTL | ferritin, light polypeptide | 0.0249998 |
| RPS17 | ribosomal protein S17 | 0.0249582 |
| RPL11 | ribosomal protein L11 | 0.0244869 |
| FAM162A | family with sequence similarity 162, member A | 0.0237831 |
| RPLP2 | ribosomal protein, large, P2 | 0.0235067 |
| FDPS | farnesyl diphosphate synthase | 0.0230687 |
| HELZ | helicase with zinc finger | 0.0230066 |
| CCNY | cyclin Y | 0.0229904 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0228258 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FAT1 | FAT atypical cadherin 1 | -0.22895 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.184106 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.159658 |
| TNS4 | tensin 4 | -0.135656 |
| ANXA2 | annexin A2 | -0.132387 |
| KRT18 | keratin 18, type I | -0.127464 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.123207 |
| ANTXR2 | anthrax toxin receptor 2 | -0.117085 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.110605 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.106697 |
| FLNB | filamin B, beta | -0.106143 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.105366 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.104979 |
| LMO7 | LIM domain 7 | -0.0997446 |
| ASPH | aspartate beta-hydroxylase | -0.0969151 |
| ITGA6 | integrin, alpha 6 | -0.0938316 |
| TPM4 | tropomyosin 4 | -0.0921185 |
| TMSB10 | thymosin beta 10 | -0.0853009 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0837323 |
| CADPS | Ca++-dependent secretion activator | -0.0816693 |
| EZR | ezrin | -0.0797508 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0792294 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0769977 |
| KRT8 | keratin 8, type II | -0.0662696 |
| ONECUT3 | one cut homeobox 3 | -0.0662132 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0652942 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0621628 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0614233 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0612068 |
| ABHD2 | abhydrolase domain containing 2 | -0.0599143 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0578884 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0542893 |
| SH3D19 | SH3 domain containing 19 | -0.0537049 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0511499 |
| ITGB4 | integrin, beta 4 | -0.0510997 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0509255 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0506444 |
| FERMT1 | fermitin family member 1 | -0.0501883 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0495765 |
| POTEF | POTE ankyrin domain family, member F | -0.0493178 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0464511 |
| LAMA4 | laminin, alpha 4 | -0.0462314 |
| H1-0 | H1.0 linker histone | -0.0455272 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0452659 |
| PRSS3 | protease, serine, 3 | -0.0450083 |
| FOSL1 | FOS-like antigen 1 | -0.0448833 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0444728 |
| EHBP1 | EH domain binding protein 1 | -0.0444703 |
| S100A6 | S100 calcium binding protein A6 | -0.0433227 |
| VCL | vinculin | -0.0428586 |
| EGR1 | early growth response 1 | -0.0412333 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0411558 |
| KIF5B | kinesin family member 5B | -0.0410626 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0398863 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0397905 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0395845 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0390503 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0386438 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0384666 |
| RAB10 | RAB10, member RAS oncogene family | -0.0379103 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0375958 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | -0.0366829 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0363729 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0360565 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0360186 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0355235 |
| FOXO1 | forkhead box O1 | -0.035256 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0350743 |
| MUC17 | mucin 17, cell surface associated | -0.0349214 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0348405 |
| LDHA | lactate dehydrogenase A | -0.034788 |
| EMP1 | epithelial membrane protein 1 | -0.034701 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0345611 |
| PKM | pyruvate kinase, muscle | -0.033667 |
| PERP | PERP, TP53 apoptosis effector | -0.0336596 |
| CD44 | CD44 molecule (Indian blood group) | -0.0330696 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0330375 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0329929 |
| MYO1E | myosin IE | -0.0329489 |
| HMGA1 | high mobility group AT-hook 1 | -0.0328353 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0323636 |
| SPON1 | spondin 1, extracellular matrix protein | -0.0323129 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0321199 |
| EPHA2 | EPH receptor A2 | -0.0320048 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0318417 |
| EFNB2 | ephrin-B2 | -0.0317407 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0316289 |
| MED13 | mediator complex subunit 13 | -0.0315645 |
| TJP2 | tight junction protein 2 | -0.031288 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0311636 |
| RNF217 | ring finger protein 217 | -0.0311478 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0311165 |
| CCND1 | cyclin D1 | -0.031113 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0310446 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0310126 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0306346 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0305616 |
| EGFR | epidermal growth factor receptor | -0.0305184 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.0298797 |
| ACTN4 | actinin, alpha 4 | -0.0293928 |
