| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cobimetinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cobimetinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.18298 |
| DST | dystonin | 0.158204 |
| COL5A2 | collagen, type V, alpha 2 | 0.124749 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.11681 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0960894 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0920337 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0913343 |
| TP63 | tumor protein p63 | 0.0875179 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.075489 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0727386 |
| ENO1 | enolase 1, (alpha) | 0.0706242 |
| ANXA1 | annexin A1 | 0.0646474 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0585425 |
| CFB | complement factor B | 0.0579153 |
| EGFR | epidermal growth factor receptor | 0.0572499 |
| EPHA4 | EPH receptor A4 | 0.0564649 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0528497 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.047583 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0464055 |
| RNF213 | ring finger protein 213 | 0.045601 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | 0.0451933 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0441063 |
| MYOF | myoferlin | 0.0425599 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0423696 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0420722 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0413231 |
| RPS8 | ribosomal protein S8 | 0.0410538 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0404627 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0403659 |
| SQSTM1 | sequestosome 1 | 0.0396067 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0389624 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0377511 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0373936 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0372681 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0369439 |
| ZNF292 | zinc finger protein 292 | 0.0357678 |
| RPS12 | ribosomal protein S12 | 0.0351484 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0345276 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0343103 |
| ADAR | adenosine deaminase, RNA-specific | 0.0342659 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0341131 |
| B2M | beta-2-microglobulin | 0.033601 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0332268 |
| TNS3 | tensin 3 | 0.0329537 |
| PHF21A | PHD finger protein 21A | 0.0325846 |
| AHNAK | AHNAK nucleoprotein | 0.0318943 |
| PRELID2 | PRELI domain containing 2 | 0.0317555 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0317273 |
| YEATS2 | YEATS domain containing 2 | 0.0316705 |
| CDK19 | cyclin-dependent kinase 19 | 0.0311547 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0311083 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0307042 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0299069 |
| DENND2B | DENN domain containing 2B | 0.0295239 |
| MB21D2 | Mab-21 domain containing 2 | 0.029505 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0294596 |
| ARRDC3 | arrestin domain containing 3 | 0.0292871 |
| FAM13A | family with sequence similarity 13, member A | 0.0292649 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0292037 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0290928 |
| KLHL24 | kelch-like family member 24 | 0.0290607 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.0288374 |
| PGK1 | phosphoglycerate kinase 1 | 0.0288014 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0286328 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0281941 |
| OGA | O-GlcNAcase | 0.0278372 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0276688 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0274526 |
| MT1E | metallothionein 1E | 0.0272311 |
| RPS6 | ribosomal protein S6 | 0.0270146 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0269406 |
| DENND5B | DENN/MADD domain containing 5B | 0.025935 |
| RPS3 | ribosomal protein S3 | 0.0258955 |
| CUL4B | cullin 4B | 0.0256405 |
| BRINP3 | bone morphogenetic protein/retinoic acid inducible neural-specific 3 | 0.0255385 |
| CEP350 | centrosomal protein 350kDa | 0.0255159 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0254467 |
| CD109 | CD109 molecule | 0.0253311 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0252187 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0251516 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0250802 |
| MEF2A | myocyte enhancer factor 2A | 0.0250737 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0248364 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0247215 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0244259 |
| WTAP | Wilms tumor 1 associated protein | 0.0244108 |
| RPS2 | ribosomal protein S2 | 0.0240495 |
| TRERF1 | transcriptional regulating factor 1 | 0.0236921 |
| LIMA1 | LIM domain and actin binding 1 | 0.02351 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0234668 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0234358 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0233914 |
| RPL23 | ribosomal protein L23 | 0.0233421 |
| RAD51B | RAD51 paralog B | 0.0233242 |
| SET | SET nuclear proto-oncogene | 0.0232557 |
| TMEM123 | transmembrane protein 123 | 0.022757 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0227409 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0220622 |
| BPTF | bromodomain PHD finger transcription factor | 0.0219796 |
| SMYD3 | SET and MYND domain containing 3 | 0.0217406 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.127254 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.115159 |
| CAPRIN2 | caprin family member 2 | -0.11498 |
| CD44 | CD44 molecule (Indian blood group) | -0.111023 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.107453 |
| FMNL2 | formin-like 2 | -0.101904 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0976759 |
| EGR1 | early growth response 1 | -0.0912331 |
| TMSB10 | thymosin beta 10 | -0.087387 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0818484 |
| RAB7A | RAB7A, member RAS oncogene family | -0.080448 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0804323 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0730578 |
| VIM | vimentin | -0.0721904 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0717119 |
| APP | amyloid beta (A4) precursor protein | -0.0711595 |
| PDE10A | phosphodiesterase 10A | -0.0701813 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0678111 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0658146 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0649428 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0649195 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0630822 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0623116 |
| TOP1 | topoisomerase (DNA) I | -0.0621541 |
| HMGA1 | high mobility group AT-hook 1 | -0.0582152 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0559823 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0549686 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0549612 |
| PTMA | prothymosin, alpha | -0.0545015 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0530906 |
| POTEF | POTE ankyrin domain family, member F | -0.0530233 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0525429 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0514934 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0513995 |
| CMIP | c-Maf inducing protein | -0.0497905 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0494961 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0494538 |
| TXNRD1 | thioredoxin reductase 1 | -0.048472 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0480888 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0480158 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0477898 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0472269 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0467164 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0444432 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | -0.0441276 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0429568 |
| FOSL1 | FOS-like antigen 1 | -0.0419886 |
| RAI1 | retinoic acid induced 1 | -0.0419508 |
| FLNB | filamin B, beta | -0.0416595 |
| PTK2 | protein tyrosine kinase 2 | -0.0415216 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0409974 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0409388 |
| PYGL | phosphorylase, glycogen, liver | -0.0388404 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0383708 |
| TMEM41B | transmembrane protein 41B | -0.0382965 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0376151 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0375875 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0375333 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0367751 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0357917 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0356186 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0355026 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0353071 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0347528 |
| EZR | ezrin | -0.0345235 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.03448 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0341217 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0338572 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.03363 |
| JUN | jun proto-oncogene | -0.0333942 |
| RAP2B | RAP2B, member of RAS oncogene family | -0.0332352 |
| PYGB | phosphorylase, glycogen; brain | -0.0325958 |
| RTTN | rotatin | -0.0322486 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0321155 |
| NHSL1 | NHS-like 1 | -0.0319295 |
| NAV2 | neuron navigator 2 | -0.031772 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0315582 |
| ACTN1 | actinin, alpha 1 | -0.0307686 |
| TGM2 | transglutaminase 2 | -0.0307052 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0305588 |
| JMJD1C | jumonji domain containing 1C | -0.0305497 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0303775 |
| NUP58 | nucleoporin 58 | -0.0300908 |
| WDR43 | WD repeat domain 43 | -0.0299205 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0298959 |
| MCL1 | myeloid cell leukemia 1 | -0.0298762 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | -0.0298386 |
| UPP1 | uridine phosphorylase 1 | -0.0289979 |
| USP36 | ubiquitin specific peptidase 36 | -0.0286667 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0284253 |
| CDK6 | cyclin-dependent kinase 6 | -0.0282587 |
| FBXO11 | F-box protein 11 | -0.0279714 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0279627 |
| TFRC | transferrin receptor | -0.0277358 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0276016 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0273631 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0272161 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0270094 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0269529 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.026837 |
