| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cobimetinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cobimetinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.164588 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.122932 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.11157 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0913188 |
| FAM13A | family with sequence similarity 13, member A | 0.0833568 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0801185 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0772208 |
| MYOF | myoferlin | 0.0771833 |
| RNF213 | ring finger protein 213 | 0.0697587 |
| FTL | ferritin, light polypeptide | 0.0590741 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0583694 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0560844 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0509589 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0501323 |
| TPD52 | tumor protein D52 | 0.0492177 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0470925 |
| ARRDC3 | arrestin domain containing 3 | 0.0469817 |
| PDE8A | phosphodiesterase 8A | 0.0469444 |
| ENO1 | enolase 1, (alpha) | 0.0383865 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.037626 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0373265 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0359004 |
| B2M | beta-2-microglobulin | 0.0352311 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.03444 |
| RNF145 | ring finger protein 145 | 0.0337431 |
| NGLY1 | N-glycanase 1 | 0.0334589 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0333996 |
| HACD2 | 3-hydroxyacyl-CoA dehydratase 2 | 0.0332893 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0324855 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0316418 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0314304 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0314272 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0305908 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.0295152 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0294792 |
| OGA | O-GlcNAcase | 0.0292879 |
| MKI67 | marker of proliferation Ki-67 | 0.0287312 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0285851 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0285169 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0281853 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0278781 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0273297 |
| PRDX1 | peroxiredoxin 1 | 0.0268995 |
| MGAT4C | MGAT4 family, member C | 0.0265788 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0259805 |
| RAB10 | RAB10, member RAS oncogene family | 0.0254714 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0254065 |
| BBX | bobby sox homolog (Drosophila) | 0.0243912 |
| SPTSSA | serine palmitoyltransferase, small subunit A | 0.0240699 |
| DSPP | dentin sialophosphoprotein | 0.0239581 |
| KIAA0319 | KIAA0319 | 0.0237531 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 0.023634 |
| PGK1 | phosphoglycerate kinase 1 | 0.0234514 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | 0.0232666 |
| RPS3 | ribosomal protein S3 | 0.0231061 |
| RAB6A | RAB6A, member RAS oncogene family | 0.022845 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0227587 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0227064 |
| ZNF292 | zinc finger protein 292 | 0.0222942 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0222043 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0219434 |
| GSTP1 | glutathione S-transferase pi 1 | 0.0218745 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0217839 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0213807 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | 0.0210965 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0210632 |
| TKT | transketolase | 0.021061 |
| RNF24 | ring finger protein 24 | 0.020684 |
| ATG14 | autophagy related 14 | 0.020657 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.0205246 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0205207 |
| DTNA | dystrobrevin, alpha | 0.0200293 |
| JAK1 | Janus kinase 1 | 0.0192755 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0191616 |
| PCDHB16 | protocadherin beta 16 | 0.0188732 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0188604 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0187635 |
| WDR45B | WD repeat domain 45B | 0.0186437 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0183547 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0181756 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | 0.0180984 |
| TMEM165 | transmembrane protein 165 | 0.0178638 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0177602 |
| SUCO | SUN domain containing ossification factor | 0.0176962 |
| NCKAP1 | NCK-associated protein 1 | 0.0176441 |
| FAM162A | family with sequence similarity 162, member A | 0.0176257 |
| YBX3 | Y box binding protein 3 | 0.0175488 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.017244 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.0172286 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0172275 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0171336 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0170472 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0168434 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0167348 |
| XPO1 | exportin 1 | 0.0167261 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0165829 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.0164597 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0164431 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.016433 |
| SEC61G | Sec61 gamma subunit | 0.016388 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.390876 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.174408 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.149877 |
| LAMC2 | laminin, gamma 2 | -0.123383 |
| SLTM | SAFB-like, transcription modulator | -0.119393 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.105734 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.100433 |
| EFNA5 | ephrin-A5 | -0.0949148 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0796398 |
| MCL1 | myeloid cell leukemia 1 | -0.077116 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0766853 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0737942 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.068913 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.068499 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0681985 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0662545 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0647818 |
| ASPH | aspartate beta-hydroxylase | -0.0646968 |
| INTS6 | integrator complex subunit 6 | -0.0646896 |
| STC1 | stanniocalcin 1 | -0.0585019 |
| LMO7 | LIM domain 7 | -0.0571144 |
| MYO1E | myosin IE | -0.0565267 |
| EGR1 | early growth response 1 | -0.055434 |
| OSMR | oncostatin M receptor | -0.0553853 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0553033 |
| NABP1 | nucleic acid binding protein 1 | -0.0522166 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0518854 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0517262 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0511676 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0491104 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0485646 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0450331 |
| LAMA4 | laminin, alpha 4 | -0.0446275 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0441131 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0429121 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0427553 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0423371 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0420766 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0416516 |
| TMSB10 | thymosin beta 10 | -0.0416228 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0405163 |
| MYO1D | myosin ID | -0.0405116 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0396921 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0396688 |
| SMAD3 | SMAD family member 3 | -0.039359 |
| CCND1 | cyclin D1 | -0.0364474 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0361004 |
| SCEL | sciellin | -0.0351789 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0342855 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0338886 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0334292 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0330395 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0321927 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0317324 |
| ACTG1 | actin gamma 1 | -0.0316834 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0314839 |
| TOP1 | topoisomerase (DNA) I | -0.0313513 |
| VCL | vinculin | -0.0312805 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0308854 |
| PRKCA | protein kinase C, alpha | -0.0302879 |
| TNS3 | tensin 3 | -0.0299706 |
| AHNAK | AHNAK nucleoprotein | -0.0296458 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0296062 |
| ATG7 | autophagy related 7 | -0.0294511 |
| CUX1 | cut-like homeobox 1 | -0.0290443 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0288913 |
| SVIL | supervillin | -0.0286542 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0285911 |
| SP100 | SP100 nuclear antigen | -0.0285792 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.028199 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.0281065 |
| CMIP | c-Maf inducing protein | -0.0279866 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0279669 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0275248 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0272724 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0270814 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0270801 |
| FOXP1 | forkhead box P1 | -0.0270435 |
| ATP11A | ATPase, class VI, type 11A | -0.0267261 |
| HOMER1 | homer scaffolding protein 1 | -0.0263226 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0258959 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0258818 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0257884 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0257843 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0255534 |
| KRT18 | keratin 18, type I | -0.0253364 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0251811 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0249759 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0249572 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0249361 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0248742 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0246743 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0243418 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0242654 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0239982 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0239702 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0237029 |
| PKM | pyruvate kinase, muscle | -0.0236994 |
| SMYD3 | SET and MYND domain containing 3 | -0.0236862 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0231796 |
