| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cobimetinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cobimetinib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FAM13A | family with sequence similarity 13, member A | 0.0935025 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0806928 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0587187 |
| ENO1 | enolase 1, (alpha) | 0.0557329 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0550728 |
| RPS12 | ribosomal protein S12 | 0.0549528 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0546605 |
| KYNU | kynureninase | 0.0513349 |
| MYOF | myoferlin | 0.048433 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0465537 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0459856 |
| ZNF292 | zinc finger protein 292 | 0.0453561 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0437217 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0429882 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0420706 |
| OGA | O-GlcNAcase | 0.0416633 |
| PTGR1 | prostaglandin reductase 1 | 0.0402959 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | 0.0394353 |
| EXOC4 | exocyst complex component 4 | 0.0383188 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0366593 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0344033 |
| B2M | beta-2-microglobulin | 0.0343065 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0341432 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0333847 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0332839 |
| RARB | retinoic acid receptor, beta | 0.0326217 |
| ADM | adrenomedullin | 0.0324292 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0320012 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0317879 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0316342 |
| NGLY1 | N-glycanase 1 | 0.0314614 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0309637 |
| USP34 | ubiquitin specific peptidase 34 | 0.0307797 |
| RPS6 | ribosomal protein S6 | 0.030342 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0302738 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0282154 |
| RPL37A | ribosomal protein L37a | 0.02814 |
| JAK1 | Janus kinase 1 | 0.0278685 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0277705 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0277548 |
| CFB | complement factor B | 0.0275531 |
| ZNF638 | zinc finger protein 638 | 0.0275168 |
| DIO2 | deiodinase, iodothyronine, type II | 0.0274098 |
| RPS8 | ribosomal protein S8 | 0.0268347 |
| TXNRD1 | thioredoxin reductase 1 | 0.0268135 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0268093 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0266063 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0265045 |
| RPL23 | ribosomal protein L23 | 0.0262475 |
| RPS3 | ribosomal protein S3 | 0.0260036 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0259763 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | 0.0254701 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0252703 |
| PRELID2 | PRELI domain containing 2 | 0.0252054 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0251659 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0251148 |
| WTAP | Wilms tumor 1 associated protein | 0.024549 |
| RAD51B | RAD51 paralog B | 0.0245151 |
| YEATS2 | YEATS domain containing 2 | 0.0244646 |
| RPL34 | ribosomal protein L34 | 0.0238764 |
| RNF213 | ring finger protein 213 | 0.0238508 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0237929 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0234139 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0232964 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0231809 |
| CA12 | carbonic anhydrase XII | 0.0230451 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0228147 |
| PHF21A | PHD finger protein 21A | 0.0227882 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0225742 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0225252 |
| ANK2 | ankyrin 2, neuronal | 0.0223034 |
| FBXO32 | F-box protein 32 | 0.0221496 |
| ARRDC3 | arrestin domain containing 3 | 0.0221063 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0220383 |
| TMEM123 | transmembrane protein 123 | 0.021829 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0217894 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0217449 |
| RPL18 | ribosomal protein L18 | 0.0217054 |
| RPL12 | ribosomal protein L12 | 0.0215603 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0215369 |
| RPS2 | ribosomal protein S2 | 0.0215043 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0207929 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0207451 |
| RPS29 | ribosomal protein S29 | 0.0207017 |
| EYA4 | EYA transcriptional coactivator and phosphatase 4 | 0.0206867 |
| NBAS | neuroblastoma amplified sequence | 0.0206501 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.020641 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.020491 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0204076 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.020327 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0201118 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.0200018 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0197582 |
| USP37 | ubiquitin specific peptidase 37 | 0.0195934 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0195824 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | 0.0194751 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.019329 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0192216 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.019204 |
| ANGPTL4 | angiopoietin-like 4 | 0.0190494 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | -0.206282 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.171461 |
| EFNA5 | ephrin-A5 | -0.12507 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.124993 |
| FN1 | fibronectin 1 | -0.122042 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.120936 |
| HMGA2 | high mobility group AT-hook 2 | -0.120794 |
| VIM | vimentin | -0.120649 |
| STC1 | stanniocalcin 1 | -0.111786 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.104302 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.102653 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.100859 |
| CDH13 | cadherin 13 | -0.0981177 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0936242 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0898886 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0880953 |
| LOX | lysyl oxidase | -0.0867544 |
| GRB10 | growth factor receptor-bound protein 10 | -0.08611 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0830496 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0799687 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0763904 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0752594 |
| NRP1 | neuropilin 1 | -0.0725222 |
| EGR1 | early growth response 1 | -0.0683027 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0639029 |
| MAP1B | microtubule-associated protein 1B | -0.0633196 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0633052 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0615458 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0614351 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0605088 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0586085 |
| CDCP1 | CUB domain containing protein 1 | -0.0584411 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0577971 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.057169 |
| TMSB10 | thymosin beta 10 | -0.0571039 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0558625 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0547224 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0492279 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0491265 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.04892 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0480338 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0474507 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0471061 |
| TGM2 | transglutaminase 2 | -0.047008 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0456084 |
| OSMR | oncostatin M receptor | -0.0454333 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0441623 |
| MTSS1 | metastasis suppressor 1 | -0.0441463 |
| GLCCI1 | glucocorticoid induced 1 | -0.0434388 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.042399 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0408765 |
| PCBP2 | poly(rC) binding protein 2 | -0.0407191 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0400922 |
| HMGA1 | high mobility group AT-hook 1 | -0.0398822 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0394476 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0391262 |
| HAS2 | hyaluronan synthase 2 | -0.0374855 |
| MCL1 | myeloid cell leukemia 1 | -0.0374138 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0344288 |
| ANKRD28 | ankyrin repeat domain 28 | -0.034314 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0341095 |
| FAM107B | family with sequence similarity 107, member B | -0.0335191 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0334579 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0329758 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0326372 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0325769 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0324856 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0322143 |
| PKM | pyruvate kinase, muscle | -0.0320143 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0311881 |
| GLIS3 | GLIS family zinc finger 3 | -0.030582 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.030098 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0300167 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.029675 |
| NTN4 | netrin 4 | -0.0288072 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0280105 |
| VMP1 | vacuole membrane protein 1 | -0.0280054 |
| CLMP | CXADR-like membrane protein | -0.0278976 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0277274 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0276469 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0273157 |
| EMP1 | epithelial membrane protein 1 | -0.027141 |
| SIK3 | SIK family kinase 3 | -0.0268966 |
| ATXN1 | ataxin 1 | -0.0266283 |
| SVIL | supervillin | -0.0263667 |
| EREG | epiregulin | -0.026315 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0262021 |
| FBXO11 | F-box protein 11 | -0.0261816 |
| FAM20C | family with sequence similarity 20, member C | -0.0261301 |
| NUMB | numb homolog (Drosophila) | -0.0261231 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.025815 |
| ECE1 | endothelin converting enzyme 1 | -0.0257448 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0256699 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.0256021 |
| TOP1 | topoisomerase (DNA) I | -0.0254741 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.025419 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0250535 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0250407 |
| VEGFA | vascular endothelial growth factor A | -0.0249803 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0249015 |
