Cobimetinib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cobimetinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cobimetinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.231571
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.117458
FGB fibrinogen beta chain 0.0920112
FTL ferritin, light polypeptide 0.0844549
RPS8 ribosomal protein S8 0.0561031
FGG fibrinogen gamma chain 0.0492791
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0490238
RPS12 ribosomal protein S12 0.0468596
FGA fibrinogen alpha chain 0.0429995
BASP1 brain abundant, membrane attached signal protein 1 0.0408092
KIAA0319 KIAA0319 0.0362307
B2M beta-2-microglobulin 0.03615
RPL37A ribosomal protein L37a 0.0306
RPL23 ribosomal protein L23 0.0304961
KTN1 kinectin 1 (kinesin receptor) 0.0304666
NNMT nicotinamide N-methyltransferase 0.0296886
RPS6 ribosomal protein S6 0.0292955
RPL19 ribosomal protein L19 0.0290249
PDE4D phosphodiesterase 4D, cAMP-specific 0.0289387
BMP5 bone morphogenetic protein 5 0.0278071
ATP5F1E ATP synthase F1 subunit epsilon 0.0275038
EIF1 eukaryotic translation initiation factor 1 0.0271473
RPS17 ribosomal protein S17 0.0271441
RPS29 ribosomal protein S29 0.0269951
RPS19 ribosomal protein S19 0.026733
RPL7 ribosomal protein L7 0.0259345
NAMPT nicotinamide phosphoribosyltransferase 0.0253718
MYOF myoferlin 0.0243813
RPLP1 ribosomal protein, large, P1 0.0238781
RPL36 ribosomal protein L36 0.0237219
RPS3 ribosomal protein S3 0.0234325
RPS2 ribosomal protein S2 0.0228791
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.022831
RPS27 ribosomal protein S27 0.0226796
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0224887
KLF6 Kruppel-like factor 6 0.0221482
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0214549
EFNA1 ephrin-A1 0.0214389
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0213296
ADAM17 ADAM metallopeptidase domain 17 0.0209204
PRR16 proline rich 16 0.0208756
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0201551
IL6 interleukin 6 0.0196746
RPL9 ribosomal protein L9 0.0194255
SOD2 superoxide dismutase 2, mitochondrial 0.0193959
LGALS1 lectin, galactoside-binding, soluble, 1 0.0180592
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0176116
RPS20 ribosomal protein S20 0.0175023
CNRIP1 cannabinoid receptor interacting protein 1 0.0173688
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0173666
RPL35A ribosomal protein L35a 0.0170698
ITGAV integrin, alpha V 0.016908
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0168835
NAP1L1 nucleosome assembly protein 1-like 1 0.0166412
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0166286
UQCRB ubiquinol-cytochrome c reductase binding protein 0.016494
RPS25 ribosomal protein S25 0.016478
ENO1 enolase 1, (alpha) 0.0163168
RPL12 ribosomal protein L12 0.0162212
MRTFA myocardin related transcription factor A 0.0161544
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0161023
HSPB1 heat shock 27kDa protein 1 0.0160862
ARRDC3 arrestin domain containing 3 0.0156138
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0152919
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0151791
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.0151436
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.015134
POTEF POTE ankyrin domain family, member F 0.0149898
ANXA1 annexin A1 0.0147585
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0145198
PDIA3 protein disulfide isomerase family A, member 3 0.0143531
RAB6A RAB6A, member RAS oncogene family 0.014286
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.014275
OGA O-GlcNAcase 0.0138106
CLU clusterin 0.0137625
S100A9 S100 calcium binding protein A9 0.0137081
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.0136472
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0134388
GGNBP2 gametogenetin binding protein 2 0.0134132
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0133499
RPS10 ribosomal protein S10 0.0133139
ISG15 ISG15 ubiquitin-like modifier 0.0133079
CXADR coxsackie virus and adenovirus receptor 0.0133047
RPL8 ribosomal protein L8 0.0132975
PABPN1 poly(A) binding protein, nuclear 1 0.0132443
RPS5 ribosomal protein S5 0.0131913
RPLP2 ribosomal protein, large, P2 0.0131273
S100A10 S100 calcium binding protein A10 0.0130378
RPS15 ribosomal protein S15 0.0129577
RPL37 ribosomal protein L37 0.0128803
GPX4 glutathione peroxidase 4 0.0128271
PDIA6 protein disulfide isomerase family A, member 6 0.0128102
RPS23 ribosomal protein S23 0.0127706
RPLP0 ribosomal protein, large, P0 0.0127676
ELL2 elongation factor, RNA polymerase II, 2 0.0125953
TPD52 tumor protein D52 0.0125892
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0125826
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0125214
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0125062
NPEPPS aminopeptidase puromycin sensitive 0.0124965

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.329504
THSD4 thrombospondin, type I, domain containing 4 -0.218759
GRAMD1B GRAM domain containing 1B -0.212344
TXNRD1 thioredoxin reductase 1 -0.157243
DOCK4 dedicator of cytokinesis 4 -0.135799
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.125073
PARD3 par-3 family cell polarity regulator -0.109111
TM4SF1 transmembrane 4 L six family member 1 -0.0934655
UBASH3B ubiquitin associated and SH3 domain containing B -0.0915488
SVIL supervillin -0.0899321
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0843097
NRG1 neuregulin 1 -0.0817098
HDAC9 histone deacetylase 9 -0.0794235
TFPI2 tissue factor pathway inhibitor 2 -0.0781328
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0773664
BICC1 BicC family RNA binding protein 1 -0.0753796
STC1 stanniocalcin 1 -0.071222
FMNL2 formin-like 2 -0.070475
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0699482
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0671884
CMIP c-Maf inducing protein -0.0655998
SLC38A2 solute carrier family 38, member 2 -0.0653335
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.063265
MAML3 mastermind-like 3 (Drosophila) -0.0624852
FAM107B family with sequence similarity 107, member B -0.0622381
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0619394
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0614849
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0606782
ERBIN erbb2 interacting protein -0.0602115
APP amyloid beta (A4) precursor protein -0.0599189
NAV3 neuron navigator 3 -0.0575752
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0568521
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0562212
DOCK5 dedicator of cytokinesis 5 -0.0559681
ANKRD11 ankyrin repeat domain 11 -0.0553192
GLIS3 GLIS family zinc finger 3 -0.0550936
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0539385
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0513436
EGFR epidermal growth factor receptor -0.0513089
PTK2 protein tyrosine kinase 2 -0.0507928
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0495873
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.047603
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0472073
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.04649
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0459847
AKAP12 A kinase (PRKA) anchor protein 12 -0.0459742
ECT2 epithelial cell transforming 2 -0.044828
WDR43 WD repeat domain 43 -0.0446833
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0446743
IER3 immediate early response 3 -0.0435546
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.043258
NHSL1 NHS-like 1 -0.0431722
USP34 ubiquitin specific peptidase 34 -0.0426352
MBNL1 muscleblind-like splicing regulator 1 -0.0425072
SAMD4A sterile alpha motif domain containing 4A -0.0408002
ZFAND3 zinc finger, AN1-type domain 3 -0.0407942
AK1 adenylate kinase 1 -0.0404505
MCL1 myeloid cell leukemia 1 -0.0396045
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0389114
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0381341
MACF1 microtubule-actin crosslinking factor 1 -0.0378494
FLNB filamin B, beta -0.0372121
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0370663
TRIO trio Rho guanine nucleotide exchange factor -0.0370507
AGO2 argonaute RISC catalytic component 2 -0.0369679
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.0366742
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0364248
KYNU kynureninase -0.0361012
UTRN utrophin -0.0360573
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0358445
OSMR oncostatin M receptor -0.0347091
EGR1 early growth response 1 -0.0345675
MT2A metallothionein 2A -0.0342778
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0341797
EFNA5 ephrin-A5 -0.0341757
TMEM131 transmembrane protein 131 -0.0340126
IGF2 insulin-like growth factor 2 -0.0334096
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0333638
CYRIB CYFIP related Rac1 interactor B -0.0332942
LDHA lactate dehydrogenase A -0.0332419
DGKD diacylglycerol kinase, delta 130kDa -0.0330481
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0325455
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0320132
THBS1 thrombospondin 1 -0.0319353
RAD51B RAD51 paralog B -0.0317965
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0317538
HMGA2 high mobility group AT-hook 2 -0.0316924
DST dystonin -0.0314182
RAD21 RAD21 homolog (S. pombe) -0.03095
MAPK8 mitogen-activated protein kinase 8 -0.0309497
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0307007
SLC38A1 solute carrier family 38, member 1 -0.0306394
BCAR3 breast cancer anti-estrogen resistance 3 -0.0306288
SMAD2 SMAD family member 2 -0.0303858
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0303671
TBC1D5 TBC1 domain family, member 5 -0.0303561
RASAL2 RAS protein activator like 2 -0.030324
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.030108
MSRB3 methionine sulfoxide reductase B3 -0.0300446
LAMB1 laminin, beta 1 -0.0300383