| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cobimetinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cobimetinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.151152 |
| KYNU | kynureninase | 0.105076 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.101672 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0964005 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0949908 |
| MYOF | myoferlin | 0.0807015 |
| FTL | ferritin, light polypeptide | 0.080524 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0736478 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0728744 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0727672 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0706436 |
| CLTC | clathrin, heavy chain (Hc) | 0.068944 |
| DSPP | dentin sialophosphoprotein | 0.0650495 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0638203 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0633221 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0613289 |
| MAP1B | microtubule-associated protein 1B | 0.0572907 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0566513 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0543661 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.053497 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0531804 |
| RPL4 | ribosomal protein L4 | 0.0507258 |
| PHF3 | PHD finger protein 3 | 0.0504735 |
| RPLP0 | ribosomal protein, large, P0 | 0.0498208 |
| PARD3 | par-3 family cell polarity regulator | 0.0496614 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0491612 |
| ELP4 | elongator acetyltransferase complex subunit 4 | 0.0484685 |
| ATP11A | ATPase, class VI, type 11A | 0.0477894 |
| RPL18 | ribosomal protein L18 | 0.0463841 |
| DENND4A | DENN/MADD domain containing 4A | 0.0459252 |
| ANXA2 | annexin A2 | 0.0458369 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0455556 |
| MSI2 | musashi RNA-binding protein 2 | 0.0449976 |
| MTDH | metadherin | 0.0438098 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0437894 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0437223 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0427426 |
| ATOSA | atos homolog A | 0.0422201 |
| CCDC88A | coiled-coil domain containing 88A | 0.04172 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0417181 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0413882 |
| RND3 | Rho family GTPase 3 | 0.0413767 |
| VCL | vinculin | 0.0410012 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0409 |
| MYO10 | myosin X | 0.0404952 |
| DST | dystonin | 0.0401215 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0400061 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0396994 |
| EGFR | epidermal growth factor receptor | 0.0396413 |
| TANK | TRAF family member-associated NFKB activator | 0.0395876 |
| PDE10A | phosphodiesterase 10A | 0.039013 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0390049 |
| SP100 | SP100 nuclear antigen | 0.0387792 |
| NIPSNAP2 | nipsnap homolog 2 | 0.0386442 |
| SIK3 | SIK family kinase 3 | 0.0381473 |
| USP34 | ubiquitin specific peptidase 34 | 0.0380724 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0380062 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0380024 |
| RPS13 | ribosomal protein S13 | 0.0378321 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.037766 |
| RAD51B | RAD51 paralog B | 0.0374083 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0372276 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0369676 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0369248 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0367134 |
| TCF12 | transcription factor 12 | 0.03638 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0361682 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0355944 |
| GPD2 | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | 0.0350413 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0350213 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0346369 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | 0.0339226 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0336458 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0336296 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0334826 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0333477 |
| COL5A2 | collagen, type V, alpha 2 | 0.0330959 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0330675 |
| RNF149 | ring finger protein 149 | 0.0315454 |
| PKN2 | protein kinase N2 | 0.0313746 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0313722 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0312557 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0311744 |
| SPAG9 | sperm associated antigen 9 | 0.0309769 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0308199 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0303203 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0298925 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0298373 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.02952 |
| YY1 | YY1 transcription factor | 0.0294164 |
| TLK1 | tousled-like kinase 1 | 0.028902 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.0288294 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0286125 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0285431 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0283554 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0280936 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0280273 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.028013 |
| ZBTB41 | zinc finger and BTB domain containing 41 | 0.0279885 |
| TRRAP | transformation/transcription domain-associated protein | 0.0279316 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.184881 |
| NDRG1 | N-myc downstream regulated 1 | -0.174479 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.150653 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.144909 |
| PTMA | prothymosin, alpha | -0.137389 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.129743 |
| TMSB10 | thymosin beta 10 | -0.117932 |
| CD109 | CD109 molecule | -0.11171 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.109171 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0853078 |
| VIM | vimentin | -0.0811646 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0803522 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0800386 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0786648 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0763285 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0761191 |
| ENO1 | enolase 1, (alpha) | -0.0758312 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0748085 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.074625 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0729043 |
| FMN1 | formin 1 | -0.0720019 |
| TPR | translocated promoter region, nuclear basket protein | -0.0710073 |
| B2M | beta-2-microglobulin | -0.0681187 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0678006 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0651891 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.064923 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0637595 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0631879 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0628742 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0624352 |
| ACTG1 | actin gamma 1 | -0.0612998 |
| HELZ | helicase with zinc finger | -0.0607777 |
| YAP1 | Yes-associated protein 1 | -0.0585892 |
| MT2A | metallothionein 2A | -0.0577801 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0574135 |
| GOLGA4 | golgin A4 | -0.0571422 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0569469 |
| RPS6 | ribosomal protein S6 | -0.0565644 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0561229 |
| PKM | pyruvate kinase, muscle | -0.0560451 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.05544 |
| RYBP | RING1 and YY1 binding protein | -0.0549005 |
| FAM13A | family with sequence similarity 13, member A | -0.0539819 |
| RUNX1 | runt-related transcription factor 1 | -0.0537065 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0530942 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0511206 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0496597 |
| FOXO3 | forkhead box O3 | -0.0493231 |
| POTEF | POTE ankyrin domain family, member F | -0.0479914 |
| LAMC2 | laminin, gamma 2 | -0.0479664 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0478787 |
| CALU | calumenin | -0.0469553 |
| RNF24 | ring finger protein 24 | -0.046832 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0466361 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0462607 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0461504 |
| S100A10 | S100 calcium binding protein A10 | -0.0459069 |
| CD44 | CD44 molecule (Indian blood group) | -0.0439832 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0437066 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.043223 |
| TFG | TRK-fused gene | -0.042704 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0423554 |
| RBM39 | RNA binding motif protein 39 | -0.0422077 |
| RLF | rearranged L-myc fusion | -0.0420669 |
| S100A6 | S100 calcium binding protein A6 | -0.0418621 |
| PCBP2 | poly(rC) binding protein 2 | -0.0415378 |
| RPS19 | ribosomal protein S19 | -0.0414933 |
| TMEM165 | transmembrane protein 165 | -0.0410676 |
| SETD5 | SET domain containing 5 | -0.040419 |
| SEPTIN7 | septin 7 | -0.040356 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0401217 |
| EZR | ezrin | -0.0400547 |
| FUS | FUS RNA binding protein | -0.0393641 |
| PGK1 | phosphoglycerate kinase 1 | -0.0387725 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0376085 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0371025 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0365916 |
| CALR | calreticulin | -0.036591 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0365366 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.03652 |
| GPC6 | glypican 6 | -0.0356989 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0355049 |
| XPO1 | exportin 1 | -0.0352643 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0351796 |
| RCOR1 | REST corepressor 1 | -0.0350201 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0344226 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0339714 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0339625 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0338885 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0337158 |
| MYO6 | myosin VI | -0.0336612 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0332779 |
| RBM25 | RNA binding motif protein 25 | -0.0331417 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0330421 |
| USP3 | ubiquitin specific peptidase 3 | -0.0328827 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0328534 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0323629 |
| USP53 | ubiquitin specific peptidase 53 | -0.0318792 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0313136 |
| RPLP1 | ribosomal protein, large, P1 | -0.031211 |
