Cobimetinib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cobimetinib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cobimetinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B 0.0912677
PDE4D phosphodiesterase 4D, cAMP-specific 0.0842641
RPS3 ribosomal protein S3 0.0756063
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0724514
RPS12 ribosomal protein S12 0.0615051
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0599575
RPL37A ribosomal protein L37a 0.0581793
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0555741
PDE10A phosphodiesterase 10A 0.0548688
ZBTB20 zinc finger and BTB domain containing 20 0.054142
RPL37 ribosomal protein L37 0.0540368
RPL26 ribosomal protein L26 0.0539952
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0537677
RPS8 ribosomal protein S8 0.0528128
IGF1R insulin-like growth factor 1 receptor 0.0518331
WWOX WW domain containing oxidoreductase 0.0510349
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0485129
BMP5 bone morphogenetic protein 5 0.0478783
IFI6 interferon, alpha-inducible protein 6 0.0453937
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0453273
PRELID2 PRELI domain containing 2 0.0447751
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0447225
MED13L mediator complex subunit 13-like 0.0445682
NCOA7 nuclear receptor coactivator 7 0.0440976
PCLO piccolo presynaptic cytomatrix protein 0.0439643
RPL12 ribosomal protein L12 0.0437468
RPL35A ribosomal protein L35a 0.0434486
EXOC4 exocyst complex component 4 0.0423746
RIMS2 regulating synaptic membrane exocytosis 2 0.0422194
ZNF292 zinc finger protein 292 0.041373
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0410966
DENND5B DENN/MADD domain containing 5B 0.040068
RNF213 ring finger protein 213 0.0400281
RPS29 ribosomal protein S29 0.039676
ENO1 enolase 1, (alpha) 0.0389933
DST dystonin 0.0380632
BBX bobby sox homolog (Drosophila) 0.0378192
NAP1L1 nucleosome assembly protein 1-like 1 0.0370862
SSH2 slingshot protein phosphatase 2 0.0368115
RPL23 ribosomal protein L23 0.0354202
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.035343
TXNRD1 thioredoxin reductase 1 0.0348441
MBNL2 muscleblind-like splicing regulator 2 0.0344105
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0341873
RPL19 ribosomal protein L19 0.0341203
BASP1 brain abundant, membrane attached signal protein 1 0.033249
MKI67 marker of proliferation Ki-67 0.0332044
RPL11 ribosomal protein L11 0.0329334
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0326033
RPS27 ribosomal protein S27 0.032324
TAS2R14 taste receptor, type 2, member 14 0.0320608
KIAA1328 KIAA1328 0.0319749
RPL32 ribosomal protein L32 0.0315932
RPS6 ribosomal protein S6 0.0315203
SMYD3 SET and MYND domain containing 3 0.031406
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0312706
RPL34 ribosomal protein L34 0.0312359
PDE4B phosphodiesterase 4B, cAMP-specific 0.0302551
PTMA prothymosin, alpha 0.0302307
MACROD2 MACRO domain containing 2 0.0293948
TPI1 triosephosphate isomerase 1 0.0288955
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0286718
ANKRD12 ankyrin repeat domain 12 0.0286375
RPL5 ribosomal protein L5 0.0284391
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0282703
ATXN1 ataxin 1 0.0279525
GNAS GNAS complex locus 0.0279512
ZBTB10 zinc finger and BTB domain containing 10 0.0278062
WSB1 WD repeat and SOCS box containing 1 0.0277758
TENM3 teneurin transmembrane protein 3 0.027548
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.027481
B2M beta-2-microglobulin 0.0274696
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0272984
RPL36 ribosomal protein L36 0.0271493
BABAM2 BRISC and BRCA1 A complex member 2 0.0270949
HLA-B major histocompatibility complex, class I, B 0.0268004
RPS19 ribosomal protein S19 0.0263461
ADAR adenosine deaminase, RNA-specific 0.0262353
EIF1 eukaryotic translation initiation factor 1 0.0260914
OGA O-GlcNAcase 0.0259233
RPS27A ribosomal protein S27a 0.0258788
RPLP2 ribosomal protein, large, P2 0.0253954
TPT1 tumor protein, translationally-controlled 1 0.025249
RPS2 ribosomal protein S2 0.0252333
RPS17 ribosomal protein S17 0.0248088
RPL31 ribosomal protein L31 0.0245069
RPS15 ribosomal protein S15 0.0242247
SYT1 synaptotagmin I 0.0239066
NFE2L2 nuclear factor, erythroid 2-like 2 0.0233229
RNF145 ring finger protein 145 0.0232564
SPIDR scaffolding protein involved in DNA repair 0.0232441
PNISR PNN-interacting serine/arginine-rich protein 0.0230426
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0229898
GSTP1 glutathione S-transferase pi 1 0.0229433
HSPB1 heat shock 27kDa protein 1 0.0228896
CDK19 cyclin-dependent kinase 19 0.022758
PARP12 poly (ADP-ribose) polymerase family, member 12 0.0226936
RPL35 ribosomal protein L35 0.0225043
MYOF myoferlin 0.0224526
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 0.0223176

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.280593
EGR1 early growth response 1 -0.163659
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0980282
MCL1 myeloid cell leukemia 1 -0.0943683
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0888054
RAB7A RAB7A, member RAS oncogene family -0.0821436
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0799288
COPA coatomer protein complex, subunit alpha -0.079731
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0790679
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0653865
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.062582
THSD4 thrombospondin, type I, domain containing 4 -0.059856
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0595945
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0563404
BRD2 bromodomain containing 2 -0.0533837
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0502596
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0494085
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0487376
EEF2 eukaryotic translation elongation factor 2 -0.0485173
POTEF POTE ankyrin domain family, member F -0.0479309
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0473177
TPM3 tropomyosin 3 -0.0471736
CCNL1 cyclin L1 -0.0457442
FMNL2 formin-like 2 -0.044881
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0444139
LRPPRC leucine-rich pentatricopeptide repeat containing -0.044003
STC1 stanniocalcin 1 -0.0434576
ERRFI1 ERBB receptor feedback inhibitor 1 -0.043456
NABP1 nucleic acid binding protein 1 -0.0419506
SETX senataxin -0.041795
LOC102724023 ES1 protein homolog, mitochondrial -0.0408754
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0400431
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0393974
MCTP1 multiple C2 domains, transmembrane 1 -0.0393251
VMP1 vacuole membrane protein 1 -0.0390166
YBX1 Y box binding protein 1 -0.0380063
TLN1 talin 1 -0.0376125
MARCHF4 membrane associated ring-CH-type finger 4 -0.0376124
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0362173
ACTN1 actinin, alpha 1 -0.0357311
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0353862
KRT18 keratin 18, type I -0.0352595
KDM2A lysine (K)-specific demethylase 2A -0.0348389
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0342867
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0335076
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0330551
GLS2 glutaminase 2 (liver, mitochondrial) -0.0324612
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0324452
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0317033
CRY1 cryptochrome circadian clock 1 -0.0313435
CAMTA1 calmodulin binding transcription activator 1 -0.0312536
EXT1 exostosin glycosyltransferase 1 -0.030913
JMJD1C jumonji domain containing 1C -0.0307419
COG5 component of oligomeric golgi complex 5 -0.0306366
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.030141
PFN1 profilin 1 -0.0300676
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0299979
WASF2 WAS protein family, member 2 -0.0299918
NF1 neurofibromin 1 -0.0299605
NOP58 NOP58 ribonucleoprotein -0.0286963
STK4 serine/threonine kinase 4 -0.0284705
ELL2 elongation factor, RNA polymerase II, 2 -0.0276625
ARF4 ADP-ribosylation factor 4 -0.0275939
CDK17 cyclin-dependent kinase 17 -0.0274667
PIBF1 progesterone immunomodulatory binding factor 1 -0.0274523
TFPI2 tissue factor pathway inhibitor 2 -0.0273839
PDLIM5 PDZ and LIM domain 5 -0.0272957
ANXA5 annexin A5 -0.0272906
RBM25 RNA binding motif protein 25 -0.0272515
DOCK5 dedicator of cytokinesis 5 -0.0271266
PTK2 protein tyrosine kinase 2 -0.0270943
AGO2 argonaute RISC catalytic component 2 -0.0268324
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0266576
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0264845
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0264195
E2F3 E2F transcription factor 3 -0.0263006
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0261796
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0260624
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0254478
RHEB Ras homolog enriched in brain -0.0254104
SRPK1 SRSF protein kinase 1 -0.0253463
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0252291
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0251587
NUP58 nucleoporin 58 -0.0250334
CANX calnexin -0.024941
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0248012
RLF rearranged L-myc fusion -0.0246847
WNT2B wingless-type MMTV integration site family, member 2B -0.024653
UBE2H ubiquitin-conjugating enzyme E2H -0.024583
ZSWIM6 zinc finger, SWIM-type containing 6 -0.024508
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0244353
PCBP2 poly(rC) binding protein 2 -0.0243972
ACBD3 acyl-CoA binding domain containing 3 -0.0240709
SRRM2 serine/arginine repetitive matrix 2 -0.0240139
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0237457
NTSR1 neurotensin receptor 1 (high affinity) -0.0237079
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0236233
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0236206
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0236118
WNK1 WNK lysine deficient protein kinase 1 -0.0235853