| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cobimetinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cobimetinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.114323 |
| RNF213 | ring finger protein 213 | 0.0881582 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0868056 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0839423 |
| PTMA | prothymosin, alpha | 0.0829907 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.080467 |
| ENO1 | enolase 1, (alpha) | 0.0802668 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0797496 |
| FHIT | fragile histidine triad | 0.0758788 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0725857 |
| FAM13A | family with sequence similarity 13, member A | 0.0686809 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0678231 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0653747 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.0641464 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0641338 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.062839 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0603069 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0600233 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0588705 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0584811 |
| FBXO32 | F-box protein 32 | 0.0576854 |
| FTL | ferritin, light polypeptide | 0.0542276 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0529703 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0526959 |
| MX1 | MX dynamin-like GTPase 1 | 0.0517091 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.051534 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0509462 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0500852 |
| RPS6 | ribosomal protein S6 | 0.0495809 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0494621 |
| CD47 | CD47 molecule | 0.048652 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0482645 |
| RPS3 | ribosomal protein S3 | 0.0481387 |
| TXNIP | thioredoxin interacting protein | 0.0477218 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.046471 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0460336 |
| B2M | beta-2-microglobulin | 0.0459896 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0447988 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0440292 |
| RAD51B | RAD51 paralog B | 0.0435509 |
| TMSB10 | thymosin beta 10 | 0.0410064 |
| RPS19 | ribosomal protein S19 | 0.0408325 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0403054 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0402073 |
| MYOF | myoferlin | 0.0399846 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0398311 |
| RPS29 | ribosomal protein S29 | 0.0382711 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0373456 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0373035 |
| ADAR | adenosine deaminase, RNA-specific | 0.0372684 |
| RPL23 | ribosomal protein L23 | 0.0366114 |
| CFB | complement factor B | 0.0363399 |
| RPS8 | ribosomal protein S8 | 0.0352491 |
| RPL34 | ribosomal protein L34 | 0.0351445 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0349089 |
| RPS12 | ribosomal protein S12 | 0.0346153 |
| RPL8 | ribosomal protein L8 | 0.0338059 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0336838 |
| RPLP2 | ribosomal protein, large, P2 | 0.0334188 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0333049 |
| PRELID2 | PRELI domain containing 2 | 0.0332937 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0331351 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0330743 |
| MUC1 | mucin 1, cell surface associated | 0.0322268 |
| MX2 | MX dynamin-like GTPase 2 | 0.032202 |
| RPL37A | ribosomal protein L37a | 0.0319888 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0318612 |
| RPL35A | ribosomal protein L35a | 0.0314366 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.0313486 |
| STEAP4 | STEAP family member 4 | 0.0312872 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.0308652 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0308109 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.030364 |
| LRRC1 | leucine rich repeat containing 1 | 0.0297307 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0292167 |
| IFI44L | interferon-induced protein 44-like | 0.0290363 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0288123 |
| PCDH7 | protocadherin 7 | 0.0283115 |
| DSTN | destrin (actin depolymerizing factor) | 0.0281199 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0279989 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0279673 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0278396 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0277187 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0275116 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | 0.0272984 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0272975 |
| RPL37 | ribosomal protein L37 | 0.0272938 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.027098 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0270451 |
| CTSB | cathepsin B | 0.0270342 |
| RPS17 | ribosomal protein S17 | 0.0270086 |
| RPL32 | ribosomal protein L32 | 0.0270032 |
| RPL19 | ribosomal protein L19 | 0.0261606 |
| RPL9 | ribosomal protein L9 | 0.0259501 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0257272 |
| HMGB2 | high mobility group box 2 | 0.025399 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0253927 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0253175 |
| DENND1B | DENN/MADD domain containing 1B | 0.0250866 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0250856 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.249157 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.222733 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.167499 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.144558 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.135046 |
| GRB10 | growth factor receptor-bound protein 10 | -0.130289 |
| ACTG1 | actin gamma 1 | -0.122413 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.100191 |
| LMO7 | LIM domain 7 | -0.0931358 |
| FN1 | fibronectin 1 | -0.0918226 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0908758 |
| FAM3C | family with sequence similarity 3, member C | -0.0776724 |
| ASPH | aspartate beta-hydroxylase | -0.0753651 |
| LAMC2 | laminin, gamma 2 | -0.0746205 |
| TOP1 | topoisomerase (DNA) I | -0.0729662 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0653645 |
| LAMB3 | laminin, beta 3 | -0.065114 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0622257 |
| DTNA | dystrobrevin, alpha | -0.0617183 |
| HMGA1 | high mobility group AT-hook 1 | -0.058156 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0574334 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0565499 |
| RCOR1 | REST corepressor 1 | -0.0557983 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0531789 |
| CDCP1 | CUB domain containing protein 1 | -0.0531151 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0524141 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0499219 |
| RASA2 | RAS p21 protein activator 2 | -0.0482427 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0471317 |
| SMAD3 | SMAD family member 3 | -0.045711 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0444955 |
| EGR1 | early growth response 1 | -0.0439515 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0439402 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0436748 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0433644 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0433123 |
| SPAG9 | sperm associated antigen 9 | -0.0425206 |
| FAM107B | family with sequence similarity 107, member B | -0.0408374 |
| CCND1 | cyclin D1 | -0.0404486 |
| PLEC | plectin | -0.0399063 |
| MYO5B | myosin VB | -0.0398651 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0397436 |
| PTK2 | protein tyrosine kinase 2 | -0.0393683 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.039316 |
| USP3 | ubiquitin specific peptidase 3 | -0.0391669 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0390584 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.038537 |
| MAP1B | microtubule-associated protein 1B | -0.038139 |
| EZR | ezrin | -0.0379264 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.037851 |
| DUSP6 | dual specificity phosphatase 6 | -0.0375572 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0359039 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0351171 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0349963 |
| UPP1 | uridine phosphorylase 1 | -0.0348662 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0343926 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0343752 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.034267 |
| FOSL1 | FOS-like antigen 1 | -0.0336476 |
| CD44 | CD44 molecule (Indian blood group) | -0.0335896 |
| DUSP10 | dual specificity phosphatase 10 | -0.032785 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | -0.0323753 |
| NUP58 | nucleoporin 58 | -0.0320694 |
| SDC4 | syndecan 4 | -0.0318225 |
| USP53 | ubiquitin specific peptidase 53 | -0.0315163 |
| TJP1 | tight junction protein 1 | -0.0314792 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0314464 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0314046 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0309843 |
| AFDN | afadin, adherens junction formation factor | -0.0303982 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0299896 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0298724 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0295385 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0294004 |
| TP53BP2 | tumor protein p53 binding protein 2 | -0.0292245 |
| VGLL3 | vestigial-like family member 3 | -0.0291626 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0291391 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0291224 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0287811 |
| ETV5 | ets variant 5 | -0.0285683 |
| ATP13A3 | ATPase type 13A3 | -0.0284788 |
| ANXA5 | annexin A5 | -0.0284034 |
| COPA | coatomer protein complex, subunit alpha | -0.0282716 |
| MEF2A | myocyte enhancer factor 2A | -0.0278419 |
| ANXA2 | annexin A2 | -0.0277528 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0276148 |
| AREG | amphiregulin | -0.0269261 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0268758 |
| ATP11B | ATPase, class VI, type 11B | -0.0268355 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0268182 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0267948 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0261189 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0260169 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0258338 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0258176 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0258164 |
| MYO10 | myosin X | -0.0257403 |
| TMEM165 | transmembrane protein 165 | -0.0257322 |
| RTN4 | reticulon 4 | -0.0255497 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | -0.0255145 |
