Cobimetinib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cobimetinib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cobimetinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.212541
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.181194
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.168184
PM20D1 peptidase M20 domain containing 1 0.147724
COL5A2 collagen, type V, alpha 2 0.135343
MYOF myoferlin 0.113506
NAMPT nicotinamide phosphoribosyltransferase 0.0991547
AGTPBP1 ATP/GTP binding protein 1 0.0916237
BASP1 brain abundant, membrane attached signal protein 1 0.0899889
COL8A1 collagen, type VIII, alpha 1 0.0859463
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.077722
NEK7 NIMA-related kinase 7 0.0768714
PALLD palladin, cytoskeletal associated protein 0.0752831
SPAG9 sperm associated antigen 9 0.0735651
TRIO trio Rho guanine nucleotide exchange factor 0.0714916
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0710772
LIMCH1 LIM and calponin homology domains 1 0.0640831
KMT2C lysine (K)-specific methyltransferase 2C 0.0626822
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0614344
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0601906
ESYT2 extended synaptotagmin-like protein 2 0.0599458
TXNRD1 thioredoxin reductase 1 0.0597772
TGFBI transforming growth factor, beta-induced, 68kDa 0.058919
DGKD diacylglycerol kinase, delta 130kDa 0.0574139
OGA O-GlcNAcase 0.056727
EIF1 eukaryotic translation initiation factor 1 0.0566972
FTL ferritin, light polypeptide 0.0554529
ANXA1 annexin A1 0.0535136
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0533638
ENO1 enolase 1, (alpha) 0.0532673
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0524566
DDIT4 DNA-damage-inducible transcript 4 0.0516573
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0506217
SMYD3 SET and MYND domain containing 3 0.0501085
PPP1R3C protein phosphatase 1, regulatory subunit 3C 0.0483196
WSB1 WD repeat and SOCS box containing 1 0.0466323
FAM13A family with sequence similarity 13, member A 0.0463414
ZNF292 zinc finger protein 292 0.0453568
RPL12 ribosomal protein L12 0.0448865
MXI1 MAX interactor 1, dimerization protein 0.0444018
P3H2 prolyl 3-hydroxylase 2 0.0443113
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0440326
RPS6 ribosomal protein S6 0.0440064
NAP1L1 nucleosome assembly protein 1-like 1 0.0439634
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0433849
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0431281
WARS1 tryptophanyl-tRNA synthetase 1 0.0431103
PTGR1 prostaglandin reductase 1 0.0430448
MAP7 microtubule-associated protein 7 0.0427693
B2M beta-2-microglobulin 0.0418592
PRELID2 PRELI domain containing 2 0.0405458
SLF1 SMC5-SMC6 complex localization factor 1 0.0402581
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0399029
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0395173
LSAMP limbic system-associated membrane protein 0.0394651
RPS12 ribosomal protein S12 0.0394209
AKR1C1 aldo-keto reductase family 1, member C1 0.0393147
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0392842
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0373282
ANXA2 annexin A2 0.0372962
RPS2 ribosomal protein S2 0.0366721
PDE10A phosphodiesterase 10A 0.0366159
ADGRB3 adhesion G protein-coupled receptor B3 0.0361823
PTEN phosphatase and tensin homolog 0.0361208
PCDH15 protocadherin-related 15 0.0358147
GNAS GNAS complex locus 0.0354264
RPS3 ribosomal protein S3 0.0348689
DST dystonin 0.034867
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0347704
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0344679
CD109 CD109 molecule 0.0344475
SAMD4A sterile alpha motif domain containing 4A 0.0338219
PGK1 phosphoglycerate kinase 1 0.0333401
KMT2E lysine (K)-specific methyltransferase 2E 0.0332435
EZR ezrin 0.0332423
ZEB2 zinc finger E-box binding homeobox 2 0.032472
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0322052
RPL26 ribosomal protein L26 0.0317921
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0315526
DISP1 dispatched homolog 1 (Drosophila) 0.0313665
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0310811
PRRC2C proline-rich coiled-coil 2C 0.0305827
SET SET nuclear proto-oncogene 0.0305028
ASPH aspartate beta-hydroxylase 0.0301916
CANX calnexin 0.0300366
MARCHF1 membrane associated ring-CH-type finger 1 0.0297523
ELL2 elongation factor, RNA polymerase II, 2 0.0294322
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0288816
LMNA lamin A/C 0.0288748
ZFHX3 zinc finger homeobox 3 0.0286111
MKI67 marker of proliferation Ki-67 0.0281524
EIF4A1 eukaryotic translation initiation factor 4A1 0.0280033
NALF1 NALCN channel auxiliary factor 1 0.0274531
RPL23 ribosomal protein L23 0.0272658
NBEAL1 neurobeachin-like 1 0.0268942
TPD52 tumor protein D52 0.0263099
STC2 stanniocalcin 2 0.026015
USP9X ubiquitin specific peptidase 9, X-linked 0.025816
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0257715
IGF1R insulin-like growth factor 1 receptor 0.0254515

decreased expression

Symbol Name Standardized Value
GDA guanine deaminase -0.150304
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.138543
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.119497
EFNA5 ephrin-A5 -0.114464
PSD3 pleckstrin and Sec7 domain containing 3 -0.108574
NRCAM neuronal cell adhesion molecule -0.0939849
MCL1 myeloid cell leukemia 1 -0.088133
CDH13 cadherin 13 -0.084693
DOCK4 dedicator of cytokinesis 4 -0.0844729
NPAS2 neuronal PAS domain protein 2 -0.0794194
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0770847
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0741815
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0682209
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0661689
STC1 stanniocalcin 1 -0.0650702
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0633063
GRAMD1B GRAM domain containing 1B -0.0616824
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0611179
VIM vimentin -0.0579589
MAML3 mastermind-like 3 (Drosophila) -0.0545422
RTN1 reticulon 1 -0.0533598
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0486758
DOCK5 dedicator of cytokinesis 5 -0.048189
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0463359
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0442771
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0430568
TFPI2 tissue factor pathway inhibitor 2 -0.0429881
FTH1 ferritin, heavy polypeptide 1 -0.0408833
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0372019
THSD4 thrombospondin, type I, domain containing 4 -0.0340816
FMNL2 formin-like 2 -0.0327758
SMOC1 SPARC related modular calcium binding 1 -0.0322248
GLIS3 GLIS family zinc finger 3 -0.0315318
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.030913
PCBP3 poly(rC) binding protein 3 -0.0307714
AKAP13 A kinase (PRKA) anchor protein 13 -0.0299123
RPL31 ribosomal protein L31 -0.0289189
BMERB1 bMERB domain containing 1 -0.0286338
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0284013
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0282306
RAB3B RAB3B, member RAS oncogene family -0.0266893
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0255193
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0253926
EGR1 early growth response 1 -0.0248563
COL4A5 collagen, type IV, alpha 5 -0.0246801
ESM1 endothelial cell-specific molecule 1 -0.0243802
PYGL phosphorylase, glycogen, liver -0.0240423
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0239235
COL4A6 collagen, type IV, alpha 6 -0.0233525
BCAR3 breast cancer anti-estrogen resistance 3 -0.0233459
MCTP1 multiple C2 domains, transmembrane 1 -0.0233018
TPT1 tumor protein, translationally-controlled 1 -0.0231729
VCL vinculin -0.0231622
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0230546
CTSL cathepsin L -0.0230015
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0223131
NT5E 5'-nucleotidase, ecto (CD73) -0.0220379
CD44 CD44 molecule (Indian blood group) -0.0215506
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0205903
DUSP4 dual specificity phosphatase 4 -0.0203682
NHSL1 NHS-like 1 -0.0201281
INTS6 integrator complex subunit 6 -0.0199216
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0198474
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0198205
ADGRD1 adhesion G protein-coupled receptor D1 -0.0197918
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0195094
RGS2 regulator of G-protein signaling 2 -0.0190594
WWTR1 WW domain containing transcription regulator 1 -0.0189712
LAMB1 laminin, beta 1 -0.0174307
RPS24 ribosomal protein S24 -0.0173563
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.0171073
BMP6 bone morphogenetic protein 6 -0.0170638
ANTXR1 anthrax toxin receptor 1 -0.0161845
ITGB5 integrin, beta 5 -0.0161028
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0160897
EPHA4 EPH receptor A4 -0.0156956
VMP1 vacuole membrane protein 1 -0.0156926
CDCP1 CUB domain containing protein 1 -0.0155481
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0153492
EVA1C eva-1 homolog C (C. elegans) -0.0152962
CLMP CXADR-like membrane protein -0.0149694
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0149538
CAPN2 calpain 2, (m/II) large subunit -0.0148735
PRRC2B proline-rich coiled-coil 2B -0.0145445
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.014523
PCED1B PC-esterase domain containing 1B -0.0144874
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.014409
HMGA2 high mobility group AT-hook 2 -0.0143537
RANBP17 RAN binding protein 17 -0.0143462
LAMA5 laminin, alpha 5 -0.0140344
NABP1 nucleic acid binding protein 1 -0.0136669
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0134574
NTSR1 neurotensin receptor 1 (high affinity) -0.0132814
AKAP12 A kinase (PRKA) anchor protein 12 -0.0132546
ARHGAP5 Rho GTPase activating protein 5 -0.0132417
MACF1 microtubule-actin crosslinking factor 1 -0.0132307
FAM107B family with sequence similarity 107, member B -0.0131981
ATP13A3 ATPase type 13A3 -0.0131548
CREM cAMP responsive element modulator -0.0129323
MSN moesin -0.0128886