Cobimetinib_NCI-H596 Gene Set
Genes
43 genes differentially expressed following the Cobimetinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
ARHGAP32
|
Rho GTPase activating protein 32
|
0.245054
|
|
UBR5
|
ubiquitin protein ligase E3 component n-recognin 5
|
0.2269
|
|
ERC1
|
ELKS/RAB6-interacting/CAST family member 1
|
0.219168
|
|
PPFIBP1
|
PTPRF interacting protein, binding protein 1 (liprin beta 1)
|
0.170773
|
|
EGFR
|
epidermal growth factor receptor
|
0.160391
|
|
B2M
|
beta-2-microglobulin
|
0.147153
|
|
ROBO2
|
roundabout, axon guidance receptor, homolog 2 (Drosophila)
|
0.123259
|
|
PKM
|
pyruvate kinase, muscle
|
0.0924386
|
|
AKAP12
|
A kinase (PRKA) anchor protein 12
|
0.0919526
|
|
MKLN1
|
muskelin 1, intracellular mediator containing kelch motifs
|
0.0865842
|
|
AHNAK
|
AHNAK nucleoprotein
|
0.0760629
|
|
IMMP2L
|
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
|
0.0746852
|
|
GOLGA4
|
golgin A4
|
0.0629769
|
|
NKD1
|
naked cuticle homolog 1 (Drosophila)
|
0.0626551
|
|
BRAF
|
B-Raf proto-oncogene, serine/threonine kinase
|
0.0571514
|
|
NF1
|
neurofibromin 1
|
0.0393652
|
|
STC1
|
stanniocalcin 1
|
0.0379255
|
|
NCKAP5
|
NCK-associated protein 5
|
0.0310477
|
|
ZNF292
|
zinc finger protein 292
|
0.0224038
|
|
MYO1E
|
myosin IE
|
0.0124367
|
|
GLS2
|
glutaminase 2 (liver, mitochondrial)
|
0.0110501
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
SERPINE1
|
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
|
-0.313389
|
|
GBE1
|
glucan (1,4-alpha-), branching enzyme 1
|
-0.252689
|
|
NDRG1
|
N-myc downstream regulated 1
|
-0.243261
|
|
GAPDH
|
glyceraldehyde-3-phosphate dehydrogenase
|
-0.229881
|
|
PTMA
|
prothymosin, alpha
|
-0.216359
|
|
PABPC1
|
poly(A) binding protein, cytoplasmic 1
|
-0.194995
|
|
VIM
|
vimentin
|
-0.184946
|
|
FNDC3B
|
fibronectin type III domain containing 3B
|
-0.17366
|
|
HSP90B1
|
heat shock protein 90kDa beta (Grp94), member 1
|
-0.125164
|
|
CD55
|
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
|
-0.123727
|
|
EFNA5
|
ephrin-A5
|
-0.120536
|
|
TMSB10
|
thymosin beta 10
|
-0.100075
|
|
HSP90AB1
|
heat shock protein 90kDa alpha (cytosolic), class B member 1
|
-0.0956358
|
|
HSPA5
|
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
|
-0.0667745
|
|
CTNNB1
|
catenin (cadherin-associated protein), beta 1, 88kDa
|
-0.0638749
|
|
FN1
|
fibronectin 1
|
-0.0620711
|
|
TPT1
|
tumor protein, translationally-controlled 1
|
-0.0602566
|
|
LSAMP
|
limbic system-associated membrane protein
|
-0.0504231
|
|
TRIQK
|
triple QxxK/R motif containing
|
-0.0227743
|
|
ASPH
|
aspartate beta-hydroxylase
|
-0.0207953
|
|
ERRFI1
|
ERBB receptor feedback inhibitor 1
|
-0.0199244
|
|
ERO1A
|
endoplasmic reticulum oxidoreductase 1 alpha
|
-0.0015207
|
