| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cobimetinib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cobimetinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.164557 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.120993 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.10521 |
| MKI67 | marker of proliferation Ki-67 | 0.097509 |
| COL5A2 | collagen, type V, alpha 2 | 0.0944428 |
| CENPF | centromere protein F, 350/400kDa | 0.0932942 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0781169 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0662212 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0659203 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.063159 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.059453 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0561362 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.055604 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.053812 |
| COL3A1 | collagen, type III, alpha 1 | 0.0520699 |
| XPO1 | exportin 1 | 0.0519012 |
| RPS2 | ribosomal protein S2 | 0.0516801 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0495896 |
| FIGN | fidgetin | 0.0482184 |
| H1-4 | H1.4 linker histone, cluster member | 0.0476647 |
| RPS6 | ribosomal protein S6 | 0.046152 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0452764 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0452125 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0421302 |
| CEP350 | centrosomal protein 350kDa | 0.041076 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0408472 |
| RPLP0 | ribosomal protein, large, P0 | 0.0406824 |
| ANK2 | ankyrin 2, neuronal | 0.0385761 |
| MED13L | mediator complex subunit 13-like | 0.0383121 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0380937 |
| PCDH9 | protocadherin 9 | 0.0379607 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0375588 |
| LBR | lamin B receptor | 0.0370402 |
| RPL7 | ribosomal protein L7 | 0.036901 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.0366469 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0362735 |
| DSCAM | Down syndrome cell adhesion molecule | 0.03625 |
| CCDC88A | coiled-coil domain containing 88A | 0.0353889 |
| WWOX | WW domain containing oxidoreductase | 0.0350736 |
| RPL26 | ribosomal protein L26 | 0.0350365 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0348934 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.033648 |
| RASAL2 | RAS protein activator like 2 | 0.0332959 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.032978 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | 0.0323793 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0320391 |
| PEG10 | paternally expressed 10 | 0.0316743 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.0307817 |
| RPS12 | ribosomal protein S12 | 0.0304796 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0300954 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.030052 |
| RPS4X | ribosomal protein S4, X-linked | 0.0300426 |
| CALCR | calcitonin receptor | 0.0299118 |
| ECT2 | epithelial cell transforming 2 | 0.0296538 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0296507 |
| STAG2 | stromal antigen 2 | 0.0295133 |
| CFL2 | cofilin 2 (muscle) | 0.0294527 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0294129 |
| NCKAP1 | NCK-associated protein 1 | 0.029136 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0289283 |
| CENPE | centromere protein E, 312kDa | 0.0289273 |
| RDX | radixin | 0.0288606 |
| ANXA1 | annexin A1 | 0.0283774 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.028361 |
| ENO1 | enolase 1, (alpha) | 0.0282141 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0281711 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0281081 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.0280882 |
| PRELID2 | PRELI domain containing 2 | 0.028045 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0279773 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0278528 |
| ANLN | anillin, actin binding protein | 0.0277358 |
| RPL19 | ribosomal protein L19 | 0.0276801 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.027615 |
| TOX | thymocyte selection-associated high mobility group box | 0.027597 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0274741 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.027447 |
| FOXP2 | forkhead box P2 | 0.0274373 |
| MED12L | mediator complex subunit 12-like | 0.0270866 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.026984 |
| DSTN | destrin (actin depolymerizing factor) | 0.0267445 |
| MACROD2 | MACRO domain containing 2 | 0.0266505 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0265142 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0263747 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0260784 |
| SGO2 | shugoshin 2 | 0.0258263 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.0256838 |
| RPL23 | ribosomal protein L23 | 0.0256636 |
| TPD52 | tumor protein D52 | 0.0255016 |
| RPLP1 | ribosomal protein, large, P1 | 0.0252893 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0252572 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0252159 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.0251383 |
| GLO1 | glyoxalase I | 0.0251193 |
| MYEF2 | myelin expression factor 2 | 0.0250836 |
| METAP2 | methionyl aminopeptidase 2 | 0.0250121 |
| PROS1 | protein S (alpha) | 0.0249014 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0248564 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0248322 |
| SYT1 | synaptotagmin I | 0.0247895 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TSC22D2 | TSC22 domain family, member 2 | -0.111468 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.106393 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0916209 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0907376 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0860579 |
| HDAC9 | histone deacetylase 9 | -0.0788004 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0751358 |
| VIM | vimentin | -0.0690201 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0677874 |
| PHIP | pleckstrin homology domain interacting protein | -0.0661743 |
| COL11A1 | collagen, type XI, alpha 1 | -0.065792 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0552431 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0519608 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0512042 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0508105 |
| HMGA2 | high mobility group AT-hook 2 | -0.0504788 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0490607 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0472778 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0471441 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0469983 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0456828 |
| TXNRD1 | thioredoxin reductase 1 | -0.0445678 |
| SHROOM3 | shroom family member 3 | -0.0436411 |
| PTMA | prothymosin, alpha | -0.0436319 |
| NXN | nucleoredoxin | -0.0435947 |
| PFN1 | profilin 1 | -0.0431084 |
| RBM39 | RNA binding motif protein 39 | -0.0427305 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0418537 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0413143 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.04106 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0405529 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0402023 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0394656 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | -0.0392619 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0381722 |
| RLF | rearranged L-myc fusion | -0.0377229 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0376504 |
| CALU | calumenin | -0.037497 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0371117 |
| FBL | fibrillarin | -0.0356292 |
| PRR16 | proline rich 16 | -0.0354938 |
| MAP1B | microtubule-associated protein 1B | -0.0348973 |
| LATS2 | large tumor suppressor kinase 2 | -0.0344569 |
| ITGAV | integrin, alpha V | -0.0344106 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0341106 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0341079 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0340074 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0339729 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0337856 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0336323 |
| ATXN2 | ataxin 2 | -0.0333112 |
| CCN2 | cellular communication network factor 2 | -0.0332281 |
| WDR43 | WD repeat domain 43 | -0.0328198 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0327216 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0323237 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0322198 |
| FLNB | filamin B, beta | -0.0320562 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0317325 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0316681 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | -0.0308923 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0307847 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0307481 |
| TMSB10 | thymosin beta 10 | -0.0307477 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | -0.0307322 |
| SALL4 | spalt-like transcription factor 4 | -0.0305492 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | -0.029609 |
| NRG1 | neuregulin 1 | -0.0294976 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0294072 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0293788 |
| RHEB | Ras homolog enriched in brain | -0.0292849 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0285997 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.028506 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0284505 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.027931 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0279165 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0278689 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0278133 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0277447 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0277004 |
| RFPL4B | ret finger protein-like 4B | -0.0275524 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0271936 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0271356 |
| POGZ | pogo transposable element with ZNF domain | -0.0266121 |
| GPC3 | glypican 3 | -0.0266069 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0264704 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0262611 |
| EMP1 | epithelial membrane protein 1 | -0.0261061 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0257927 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0257565 |
| CCNL1 | cyclin L1 | -0.0256953 |
| FAM168A | family with sequence similarity 168, member A | -0.0256774 |
| MAP4 | microtubule-associated protein 4 | -0.0256502 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0255939 |
| USP3 | ubiquitin specific peptidase 3 | -0.0254962 |
| TMEM87A | transmembrane protein 87A | -0.0254573 |
| SBF2 | SET binding factor 2 | -0.025374 |
| NEBL | nebulette | -0.0251863 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.024956 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0247591 |
| DOCK5 | dedicator of cytokinesis 5 | -0.024676 |
