| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cobimetinib perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cobimetinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SSBP2 | single-stranded DNA binding protein 2 | 0.137088 |
| ZNF292 | zinc finger protein 292 | 0.0958467 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0936571 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0912823 |
| ANK2 | ankyrin 2, neuronal | 0.0745982 |
| RPS6 | ribosomal protein S6 | 0.0737456 |
| B2M | beta-2-microglobulin | 0.0728835 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0703013 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0689609 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0646196 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0603193 |
| QKI | QKI, KH domain containing, RNA binding | 0.0573655 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0539778 |
| DENND4A | DENN/MADD domain containing 4A | 0.0537928 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0512799 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0502334 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0496738 |
| CCNL1 | cyclin L1 | 0.0496709 |
| RNF145 | ring finger protein 145 | 0.0493467 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.049107 |
| RPS19 | ribosomal protein S19 | 0.0488663 |
| RBM39 | RNA binding motif protein 39 | 0.0477715 |
| NCKAP1 | NCK-associated protein 1 | 0.0474787 |
| OGA | O-GlcNAcase | 0.0472965 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0456865 |
| RTN4 | reticulon 4 | 0.0455315 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0450414 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.04395 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0432891 |
| NFIA | nuclear factor I/A | 0.042948 |
| XPO1 | exportin 1 | 0.0426141 |
| MSI2 | musashi RNA-binding protein 2 | 0.0415696 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0411857 |
| RPL35A | ribosomal protein L35a | 0.0408155 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0407836 |
| GOLGA4 | golgin A4 | 0.0405385 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0403224 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0398189 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0381375 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0373443 |
| RPS2 | ribosomal protein S2 | 0.0369503 |
| HDAC9 | histone deacetylase 9 | 0.0363903 |
| MED13L | mediator complex subunit 13-like | 0.0363497 |
| RPS3 | ribosomal protein S3 | 0.0363428 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.036297 |
| RPL37A | ribosomal protein L37a | 0.0358705 |
| CDC73 | cell division cycle 73 | 0.0354408 |
| NCOR1 | nuclear receptor corepressor 1 | 0.035415 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0351771 |
| MATR3 | matrin 3 | 0.0347853 |
| FAM162A | family with sequence similarity 162, member A | 0.0343918 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0342875 |
| RPLP0 | ribosomal protein, large, P0 | 0.0340839 |
| TXNIP | thioredoxin interacting protein | 0.0340312 |
| RPL11 | ribosomal protein L11 | 0.0336889 |
| RPL26 | ribosomal protein L26 | 0.0335926 |
| HSPA4L | heat shock 70kDa protein 4-like | 0.0332791 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0330976 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0330708 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0322861 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0319821 |
| FHIT | fragile histidine triad | 0.0316129 |
| MT2A | metallothionein 2A | 0.0310401 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0309334 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0309311 |
| FTL | ferritin, light polypeptide | 0.0306764 |
| PGK1 | phosphoglycerate kinase 1 | 0.030626 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0306178 |
| HELZ | helicase with zinc finger | 0.030399 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.0299303 |
| RPL36 | ribosomal protein L36 | 0.0294778 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0290786 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0290507 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0285324 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0285057 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0283866 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0282126 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0280315 |
| SQSTM1 | sequestosome 1 | 0.0277603 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0275289 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0273873 |
| RPL34 | ribosomal protein L34 | 0.0272358 |
| FAM13A | family with sequence similarity 13, member A | 0.0272119 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0272041 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | 0.0271746 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0267912 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | 0.0266707 |
| RPS8 | ribosomal protein S8 | 0.0264753 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0264577 |
| PLCE1 | phospholipase C, epsilon 1 | 0.0263805 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0263121 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0262828 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0262008 |
| RPS12 | ribosomal protein S12 | 0.0261699 |
| TCF12 | transcription factor 12 | 0.0261279 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0261093 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0257972 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.025688 |
| CREBRF | CREB3 regulatory factor | 0.0254464 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0250918 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | -0.256723 |
| PKM | pyruvate kinase, muscle | -0.191325 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.156708 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.152108 |
| BMP10 | bone morphogenetic protein 10 | -0.145389 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.120511 |
| PTMA | prothymosin, alpha | -0.118392 |
| AHNAK | AHNAK nucleoprotein | -0.103233 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0966165 |
| CCND1 | cyclin D1 | -0.0916721 |
| GLI3 | GLI family zinc finger 3 | -0.0906117 |
| FLNB | filamin B, beta | -0.0901926 |
| EGFR | epidermal growth factor receptor | -0.0876353 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0832388 |
| NBEA | neurobeachin | -0.0824018 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0795711 |
| DUSP4 | dual specificity phosphatase 4 | -0.0710896 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0706888 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0664462 |
| GLI2 | GLI family zinc finger 2 | -0.0647628 |
| FOXP1 | forkhead box P1 | -0.0633867 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0619658 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0606652 |
| BMP2K | BMP2 inducible kinase | -0.0547606 |
| MKI67 | marker of proliferation Ki-67 | -0.0546774 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0532605 |
| MYO5C | myosin VC | -0.0529091 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0523108 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0510501 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0491412 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0480974 |
| DUSP6 | dual specificity phosphatase 6 | -0.047935 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0472281 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0470883 |
| LOXL3 | lysyl oxidase-like 3 | -0.0454945 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0451848 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0448584 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0447144 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0445078 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.0430234 |
| ECT2 | epithelial cell transforming 2 | -0.0430041 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0421412 |
| PYGB | phosphorylase, glycogen; brain | -0.041721 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.0415427 |
| EZR | ezrin | -0.0399501 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0397608 |
| PIWIL1 | piwi-like RNA-mediated gene silencing 1 | -0.0396424 |
| GSE1 | Gse1 coiled-coil protein | -0.0382254 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0381566 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0378247 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0375206 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0374432 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.037123 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.0362727 |
| PDE7B | phosphodiesterase 7B | -0.0361214 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0357272 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0349793 |
| NAV2 | neuron navigator 2 | -0.0348278 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0344586 |
| HJURP | Holliday junction recognition protein | -0.034029 |
| FER1L6 | fer-1-like family member 6 | -0.0336816 |
| POTEF | POTE ankyrin domain family, member F | -0.03318 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0327148 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0323442 |
| EBNA1BP2 | EBNA1 binding protein 2 | -0.0322518 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0321002 |
| TMSB4X | thymosin beta 4, X-linked | -0.0313075 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0312587 |
| TUBA1B | tubulin, alpha 1b | -0.0301795 |
| CENPF | centromere protein F, 350/400kDa | -0.029548 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0295288 |
| HDLBP | high density lipoprotein binding protein | -0.0294221 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | -0.0293943 |
| UBC | ubiquitin C | -0.0292936 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0291856 |
| SEPTIN9 | septin 9 | -0.0290789 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0286238 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0286112 |
| GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | -0.0285755 |
| TOB1 | transducer of ERBB2, 1 | -0.0283598 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0283336 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0280716 |
| SMNDC1 | survival motor neuron domain containing 1 | -0.0274091 |
| ITGA10 | integrin, alpha 10 | -0.0272789 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0269302 |
| TRIM24 | tripartite motif containing 24 | -0.0264433 |
| INTS6 | integrator complex subunit 6 | -0.026334 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0261384 |
| TPM4 | tropomyosin 4 | -0.0261016 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0257539 |
| SETX | senataxin | -0.0255248 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0249448 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.023725 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0236048 |
| ZNF438 | zinc finger protein 438 | -0.0233984 |
| MYO5A | myosin VA (heavy chain 12, myoxin) | -0.023204 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0231779 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0231343 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.022916 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.022845 |
