| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cobimetinib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cobimetinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FRMD4A | FERM domain containing 4A | 0.156466 |
| DST | dystonin | 0.148896 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.131736 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.131241 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.107696 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.103803 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0982945 |
| MYOF | myoferlin | 0.0974375 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.092997 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.088055 |
| RPS6 | ribosomal protein S6 | 0.0755877 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0723328 |
| B2M | beta-2-microglobulin | 0.0704162 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0700303 |
| FBXO32 | F-box protein 32 | 0.0695863 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.067165 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0669328 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0666431 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0640807 |
| RPS12 | ribosomal protein S12 | 0.0615006 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0611146 |
| ENO1 | enolase 1, (alpha) | 0.0609946 |
| LRRC7 | leucine rich repeat containing 7 | 0.0604735 |
| FTL | ferritin, light polypeptide | 0.0597652 |
| INSIG1 | insulin induced gene 1 | 0.0542928 |
| CADM1 | cell adhesion molecule 1 | 0.0528167 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.052491 |
| C3 | complement component 3 | 0.0519924 |
| ZNF292 | zinc finger protein 292 | 0.0485106 |
| RPS3 | ribosomal protein S3 | 0.0482582 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0481674 |
| ADM | adrenomedullin | 0.0456595 |
| FLNB | filamin B, beta | 0.0444725 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0444725 |
| ERBIN | erbb2 interacting protein | 0.04436 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0440231 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0437111 |
| PLIN2 | perilipin 2 | 0.0437091 |
| RNF213 | ring finger protein 213 | 0.0435356 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | 0.0425736 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0416927 |
| MX1 | MX dynamin-like GTPase 1 | 0.0402716 |
| PALLD | palladin, cytoskeletal associated protein | 0.0392566 |
| PDE10A | phosphodiesterase 10A | 0.0381104 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.037319 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0368763 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0364744 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0364282 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.0362092 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.036178 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0359419 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0351325 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0349978 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0341186 |
| CFB | complement factor B | 0.0336923 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | 0.0336014 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0333799 |
| CALD1 | caldesmon 1 | 0.0330789 |
| RNF144B | ring finger protein 144B | 0.0329841 |
| CLIC4 | chloride intracellular channel 4 | 0.0326357 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0325014 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0324947 |
| NREP | neuronal regeneration related protein | 0.0323433 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0320643 |
| AHR | aryl hydrocarbon receptor | 0.0315863 |
| POTEF | POTE ankyrin domain family, member F | 0.0310675 |
| NNMT | nicotinamide N-methyltransferase | 0.031052 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0308063 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0295393 |
| CDK19 | cyclin-dependent kinase 19 | 0.0294392 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0291007 |
| TGFB2 | transforming growth factor, beta 2 | 0.0289821 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0288633 |
| FILIP1L | filamin A interacting protein 1-like | 0.0287423 |
| HEG1 | heart development protein with EGF-like domains 1 | 0.0286641 |
| RPS19 | ribosomal protein S19 | 0.0285608 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0285302 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0283683 |
| RPL37A | ribosomal protein L37a | 0.0278535 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.027798 |
| HLA-B | major histocompatibility complex, class I, B | 0.0277404 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0276619 |
| EEA1 | early endosome antigen 1 | 0.0275882 |
| WTAP | Wilms tumor 1 associated protein | 0.0273657 |
| QKI | QKI, KH domain containing, RNA binding | 0.027242 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.0272102 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0271686 |
| RPL36 | ribosomal protein L36 | 0.0269908 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0268614 |
| WWC1 | WW and C2 domain containing 1 | 0.0268287 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.026658 |
| ARRDC3 | arrestin domain containing 3 | 0.0262913 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.02627 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.026256 |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | 0.0259343 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0256401 |
| SAMD9L | sterile alpha motif domain containing 9-like | 0.0256318 |
| FOXP1 | forkhead box P1 | 0.0253288 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0252267 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0251397 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.184534 |
| CD44 | CD44 molecule (Indian blood group) | -0.179774 |
| FN1 | fibronectin 1 | -0.146053 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.105033 |
| COL6A3 | collagen, type VI, alpha 3 | -0.10246 |
| NAV2 | neuron navigator 2 | -0.0992486 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0937424 |
| GLIS3 | GLIS family zinc finger 3 | -0.08314 |
| HMGA2 | high mobility group AT-hook 2 | -0.0801803 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0752672 |
| VCAN | versican | -0.0698823 |
| EGR1 | early growth response 1 | -0.0698506 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0676302 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0662314 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0656022 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0642705 |
| VCL | vinculin | -0.0635916 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0616722 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.060468 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.057846 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0563044 |
| CDH13 | cadherin 13 | -0.0560564 |
| STC1 | stanniocalcin 1 | -0.0554081 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0518121 |
| VIM | vimentin | -0.0499394 |
| RTN4 | reticulon 4 | -0.0498767 |
| SMAD3 | SMAD family member 3 | -0.0489035 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0485669 |
| RBM39 | RNA binding motif protein 39 | -0.0485666 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0464348 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0442666 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0438549 |
| APP | amyloid beta (A4) precursor protein | -0.0424708 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0411889 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0398915 |
| VEGFA | vascular endothelial growth factor A | -0.0390208 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0385746 |
| CDCP1 | CUB domain containing protein 1 | -0.0383534 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0380112 |
| TOP1 | topoisomerase (DNA) I | -0.0377373 |
| JMJD1C | jumonji domain containing 1C | -0.0376109 |
| SPAG9 | sperm associated antigen 9 | -0.0375316 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0374858 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0372876 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0368742 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0363634 |
| SYNJ2 | synaptojanin 2 | -0.0354312 |
| RAB7A | RAB7A, member RAS oncogene family | -0.035428 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0346686 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.034657 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0343743 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0341134 |
| MAP1B | microtubule-associated protein 1B | -0.0337167 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0332708 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0326795 |
| LOXL2 | lysyl oxidase-like 2 | -0.0325034 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0324922 |
| AFDN | afadin, adherens junction formation factor | -0.0322471 |
| RUNX1 | runt-related transcription factor 1 | -0.0317166 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0317033 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0313587 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.031292 |
| SVIL | supervillin | -0.0309328 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0308654 |
| TOX2 | TOX high mobility group box family member 2 | -0.0306995 |
| NF1 | neurofibromin 1 | -0.0297452 |
| IER3 | immediate early response 3 | -0.0296412 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0292573 |
| EFNA5 | ephrin-A5 | -0.0292566 |
| RASA2 | RAS p21 protein activator 2 | -0.0291984 |
| SDC4 | syndecan 4 | -0.0287548 |
| ARF4 | ADP-ribosylation factor 4 | -0.0284419 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0280069 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0273469 |
| RLIM | ring finger protein, LIM domain interacting | -0.02723 |
| FOSL1 | FOS-like antigen 1 | -0.027228 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0271092 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0270148 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0265101 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0263806 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0263312 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0261928 |
| CUL3 | cullin 3 | -0.025778 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0257528 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | -0.0255564 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.02552 |
| HDLBP | high density lipoprotein binding protein | -0.0254783 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0251611 |
| SEC24A | SEC24 family member A | -0.0251287 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0251013 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0250316 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0249998 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0249248 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0246229 |
| TMSB4X | thymosin beta 4, X-linked | -0.0245074 |
| SNX9 | sorting nexin 9 | -0.0244379 |
| RASA3 | RAS p21 protein activator 3 | -0.024424 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.024372 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0241332 |
| FMNL2 | formin-like 2 | -0.0238898 |
