Cobimetinib_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cobimetinib perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cobimetinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TGFBI transforming growth factor, beta-induced, 68kDa 0.0871724
TRIO trio Rho guanine nucleotide exchange factor 0.0687669
EIF1 eukaryotic translation initiation factor 1 0.0675278
TMSB10 thymosin beta 10 0.0666064
MORF4L2 mortality factor 4 like 2 0.0616688
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0588599
SOD2 superoxide dismutase 2, mitochondrial 0.0568884
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0550601
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0515193
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0489491
MBD5 methyl-CpG binding domain protein 5 0.0465387
USP34 ubiquitin specific peptidase 34 0.0458822
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0444871
ESYT2 extended synaptotagmin-like protein 2 0.0440778
PRELID2 PRELI domain containing 2 0.0437848
ZCCHC7 zinc finger, CCHC domain containing 7 0.0428096
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0384873
ZBTB20 zinc finger and BTB domain containing 20 0.0381741
BACE2 beta-site APP-cleaving enzyme 2 0.0377215
SAMD4A sterile alpha motif domain containing 4A 0.0373805
LOXL2 lysyl oxidase-like 2 0.0361205
MICU1 mitochondrial calcium uptake 1 0.0345158
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0339965
CUL4B cullin 4B 0.0336955
FSCN1 fascin actin-bundling protein 1 0.0333417
BABAM2 BRISC and BRCA1 A complex member 2 0.0330454
CLIC1 chloride intracellular channel 1 0.0327893
MLEC malectin 0.0323233
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0321369
TNS3 tensin 3 0.0315364
ENO1 enolase 1, (alpha) 0.0313738
GNAS GNAS complex locus 0.0310187
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0309529
GBP2 guanylate binding protein 2, interferon-inducible 0.0306619
RAB10 RAB10, member RAS oncogene family 0.029436
SON SON DNA binding protein 0.0292917
CD109 CD109 molecule 0.0288536
DSCAM Down syndrome cell adhesion molecule 0.0285843
SLC38A2 solute carrier family 38, member 2 0.0282909
MYOF myoferlin 0.0282379
ACTN4 actinin, alpha 4 0.0282268
RPLP1 ribosomal protein, large, P1 0.0274522
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0270308
RAI1 retinoic acid induced 1 0.0268903
EIF5B eukaryotic translation initiation factor 5B 0.0266754
PHF20 PHD finger protein 20 0.0263648
TIMP3 TIMP metallopeptidase inhibitor 3 0.0262169
FAM13A family with sequence similarity 13, member A 0.0261047
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.0259956
RPS6 ribosomal protein S6 0.0259619
NFE2L1 nuclear factor, erythroid 2-like 1 0.0258616
DNAAF9 dynein axonemal assembly factor 9 0.0257734
COPB1 coatomer protein complex, subunit beta 1 0.0255234
RPS17 ribosomal protein S17 0.025432
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0250723
RASA2 RAS p21 protein activator 2 0.0250209
ZNF532 zinc finger protein 532 0.0249622
GRIK5 glutamate receptor, ionotropic, kainate 5 0.024918
ARHGAP12 Rho GTPase activating protein 12 0.0244434
OGA O-GlcNAcase 0.0244113
SIN3B SIN3 transcription regulator family member B 0.0243567
COL8A1 collagen, type VIII, alpha 1 0.0243318
INTS6 integrator complex subunit 6 0.0242896
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.02423
CCNG2 cyclin G2 0.0240382
SBF2 SET binding factor 2 0.0240142
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.0238582
NAP1L1 nucleosome assembly protein 1-like 1 0.0237966
NAV1 neuron navigator 1 0.0236148
PARD3 par-3 family cell polarity regulator 0.0234369
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.0233215
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0231568
NCOR1 nuclear receptor corepressor 1 0.0231266
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.023108
FBXL7 F-box and leucine-rich repeat protein 7 0.0230102
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0229392
SEPTIN9 septin 9 0.0229267
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0228906
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 0.0228637
ARHGAP21 Rho GTPase activating protein 21 0.0227487
PRSS23 protease, serine, 23 0.0226941
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.022587
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0225034
COL1A2 collagen, type I, alpha 2 0.0224294
CA12 carbonic anhydrase XII 0.02227
SKAP2 src kinase associated phosphoprotein 2 0.022157
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) 0.022067
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0219616
DCLK2 doublecortin-like kinase 2 0.0218509
SSR1 signal sequence receptor, alpha 0.0218272
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0217845
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0217183
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0216785
RNF38 ring finger protein 38 0.0216279
NUCB2 nucleobindin 2 0.0216214
FHIT fragile histidine triad 0.0215223
SDC2 syndecan 2 0.0214998
RPS14 ribosomal protein S14 0.021481
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.0214303
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0213626

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.128477
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.107952
MT2A metallothionein 2A -0.0982655
MAP1B microtubule-associated protein 1B -0.0919708
COL6A3 collagen, type VI, alpha 3 -0.0879482
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.083925
TRA2A transformer 2 alpha homolog (Drosophila) -0.0832375
PTMA prothymosin, alpha -0.0770162
IGFBP3 insulin-like growth factor binding protein 3 -0.0764098
VEGFA vascular endothelial growth factor A -0.0717998
ELL2 elongation factor, RNA polymerase II, 2 -0.0714582
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0691374
FTH1 ferritin, heavy polypeptide 1 -0.068922
ZNF292 zinc finger protein 292 -0.0661713
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0621169
HLA-A major histocompatibility complex, class I, A -0.0574463
RYBP RING1 and YY1 binding protein -0.0533943
NDRG1 N-myc downstream regulated 1 -0.0515995
HDLBP high density lipoprotein binding protein -0.0510424
STC1 stanniocalcin 1 -0.0497814
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0483796
HOOK2 hook microtubule-tethering protein 2 -0.0481311
CALR calreticulin -0.0469407
MYH9 myosin, heavy chain 9, non-muscle -0.0468044
COL6A1 collagen, type VI, alpha 1 -0.0461699
HLA-B major histocompatibility complex, class I, B -0.0455972
KMT2E lysine (K)-specific methyltransferase 2E -0.0448296
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0443628
NRXN3 neurexin 3 -0.0434774
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0401736
IGFBP7 insulin-like growth factor binding protein 7 -0.0395884
RND3 Rho family GTPase 3 -0.0395802
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0393849
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.039271
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0391565
WASF2 WAS protein family, member 2 -0.038996
BHLHE40 basic helix-loop-helix family, member e40 -0.0387353
CADM1 cell adhesion molecule 1 -0.0385784
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0384608
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0380447
HILPDA hypoxia inducible lipid droplet-associated -0.0379338
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0379066
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.0377771
ECE1 endothelin converting enzyme 1 -0.0377599
EPAS1 endothelial PAS domain protein 1 -0.037378
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.03514
FTL ferritin, light polypeptide -0.0343918
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0338318
MEF2A myocyte enhancer factor 2A -0.0337958
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0336607
PKM pyruvate kinase, muscle -0.0335755
ZFC3H1 zinc finger, C3H1-type containing -0.0331127
AKAP13 A kinase (PRKA) anchor protein 13 -0.0330821
SYNJ2 synaptojanin 2 -0.0329598
TOP1 topoisomerase (DNA) I -0.0325926
NOP58 NOP58 ribonucleoprotein -0.0323633
FUS FUS RNA binding protein -0.0322107
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0321149
TTC3 tetratricopeptide repeat domain 3 -0.0320832
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0317209
BCAR3 breast cancer anti-estrogen resistance 3 -0.0315039
HIPK2 homeodomain interacting protein kinase 2 -0.0310797
INSIG2 insulin induced gene 2 -0.0310386
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0305177
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0304774
LOC112694756 uncharaterized LOC112694756 -0.0303881
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0301534
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0300897
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0299002
EGR1 early growth response 1 -0.0298495
HMGA2 high mobility group AT-hook 2 -0.0298331
MCL1 myeloid cell leukemia 1 -0.0297549
CLINT1 clathrin interactor 1 -0.0295684
CAV1 caveolin 1, caveolae protein, 22kDa -0.0295194
MARCHF6 membrane associated ring-CH-type finger 6 -0.0291735
RNF145 ring finger protein 145 -0.0291657
GLIS3 GLIS family zinc finger 3 -0.0288132
UGCG UDP-glucose ceramide glucosyltransferase -0.0280542
ZC3H11A zinc finger CCCH-type containing 11A -0.0271374
CLEC1B C-type lectin domain family 1, member B -0.0268243
SQSTM1 sequestosome 1 -0.0267229
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0266022
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0265187
TLN1 talin 1 -0.0264052
ITM2B integral membrane protein 2B -0.026283
TMEM165 transmembrane protein 165 -0.0260518
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0260272
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -0.0259497
CAMTA1 calmodulin binding transcription activator 1 -0.0258671
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0257633
TIMP2 TIMP metallopeptidase inhibitor 2 -0.025719
RSRC2 arginine/serine-rich coiled-coil 2 -0.0256526
ANLN anillin, actin binding protein -0.0255671
CCNL1 cyclin L1 -0.0254494
SHB Src homology 2 domain containing adaptor protein B -0.0253789
BASP1 brain abundant, membrane attached signal protein 1 -0.0252328
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0252039
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0251501
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0251337
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.025055