| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cobimetinib perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cobimetinib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DSCAM | Down syndrome cell adhesion molecule | 0.0957012 |
| ZNF292 | zinc finger protein 292 | 0.0793508 |
| SMYD3 | SET and MYND domain containing 3 | 0.0781636 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0635375 |
| TXNRD1 | thioredoxin reductase 1 | 0.0634211 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0629058 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0595819 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0574037 |
| TPX2 | TPX2, microtubule-associated | 0.0572631 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0563587 |
| RDX | radixin | 0.0520018 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0506005 |
| MTREX | Mtr4 exosome RNA helicase | 0.0490296 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0480544 |
| ATXN2 | ataxin 2 | 0.0479541 |
| DENND4A | DENN/MADD domain containing 4A | 0.0464676 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0464487 |
| DST | dystonin | 0.0458101 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0456043 |
| KIAA1958 | KIAA1958 | 0.0452852 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0451976 |
| GGNBP2 | gametogenetin binding protein 2 | 0.0449009 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0437641 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0436619 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0430355 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0429943 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0429785 |
| NBEA | neurobeachin | 0.0426764 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0421232 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0418252 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0417334 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0409042 |
| RIGI | RNA sensor RIG-I | 0.0401138 |
| USP37 | ubiquitin specific peptidase 37 | 0.0400235 |
| GPC6 | glypican 6 | 0.0397943 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0390066 |
| SET | SET nuclear proto-oncogene | 0.038938 |
| TMEM135 | transmembrane protein 135 | 0.0387127 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0369976 |
| USP12 | ubiquitin specific peptidase 12 | 0.0359672 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0357282 |
| SLFN11 | schlafen family member 11 | 0.0357001 |
| SPPL3 | signal peptide peptidase like 3 | 0.0353545 |
| RPL23 | ribosomal protein L23 | 0.0353232 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.0351114 |
| FAM13A | family with sequence similarity 13, member A | 0.0347919 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0346849 |
| ERBIN | erbb2 interacting protein | 0.0343883 |
| MTCH2 | mitochondrial carrier 2 | 0.0338675 |
| DYNC1I2 | dynein, cytoplasmic 1, intermediate chain 2 | 0.033213 |
| CENPP | centromere protein P | 0.0331467 |
| FNIP1 | folliculin interacting protein 1 | 0.0331447 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0325878 |
| PHF3 | PHD finger protein 3 | 0.0324846 |
| B2M | beta-2-microglobulin | 0.0321175 |
| WDR26 | WD repeat domain 26 | 0.0314084 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | 0.0312316 |
| XPO1 | exportin 1 | 0.0310482 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0309061 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0308459 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0308101 |
| RTN4 | reticulon 4 | 0.0304793 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0299707 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0293245 |
| PRKD1 | protein kinase D1 | 0.028858 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0287858 |
| RPS12 | ribosomal protein S12 | 0.0286846 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.028534 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0285046 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0283938 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | 0.0281396 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0279806 |
| WWOX | WW domain containing oxidoreductase | 0.0277324 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0275006 |
| NR2C2 | nuclear receptor subfamily 2, group C, member 2 | 0.0274774 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0271419 |
| SETD5 | SET domain containing 5 | 0.0271065 |
| R3HDM1 | R3H domain containing 1 | 0.0269889 |
| SBF2 | SET binding factor 2 | 0.0269779 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0269317 |
| YBX3 | Y box binding protein 3 | 0.0269012 |
| CABIN1 | calcineurin binding protein 1 | 0.026868 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0267445 |
| CAB39 | calcium binding protein 39 | 0.0266599 |
| HBS1L | HBS1-like translational GTPase | 0.0266504 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0264051 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | 0.026265 |
| MED13 | mediator complex subunit 13 | 0.026169 |
| SEPTIN2 | septin 2 | 0.0259063 |
| GOLIM4 | golgi integral membrane protein 4 | 0.0257119 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0255837 |
| LDHB | lactate dehydrogenase B | 0.0255215 |
| MTDH | metadherin | 0.0255024 |
| KLHL24 | kelch-like family member 24 | 0.0253864 |
| SAR1B | secretion associated, Ras related GTPase 1B | 0.0252938 |
| POGLUT3 | protein O-glucosyltransferase 3 | 0.0252487 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0250572 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0250136 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0249679 |
| SBNO2 | strawberry notch homolog 2 (Drosophila) | 0.0249461 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FNDC3B | fibronectin type III domain containing 3B | -0.101685 |
| HMGA2 | high mobility group AT-hook 2 | -0.099736 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0897258 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0788868 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0777655 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0743355 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0739488 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0729396 |
| MT2A | metallothionein 2A | -0.0723435 |
| CD44 | CD44 molecule (Indian blood group) | -0.0696451 |
| AHNAK | AHNAK nucleoprotein | -0.0691935 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0652299 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0644938 |
| VIM | vimentin | -0.0634948 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0571383 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0561414 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0555537 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0544874 |
| TMSB10 | thymosin beta 10 | -0.0543871 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.052831 |
| PKM | pyruvate kinase, muscle | -0.052611 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0512086 |
| EGR1 | early growth response 1 | -0.050039 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0499202 |
| MCL1 | myeloid cell leukemia 1 | -0.048226 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0478632 |
| SMAD3 | SMAD family member 3 | -0.0477885 |
| LDHA | lactate dehydrogenase A | -0.0476455 |
| CALU | calumenin | -0.0463202 |
| FLNA | filamin A, alpha | -0.0461271 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0460739 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0459842 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0458512 |
| ANGPTL4 | angiopoietin-like 4 | -0.0451871 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0451149 |
| PRR16 | proline rich 16 | -0.0423998 |
| DTNA | dystrobrevin, alpha | -0.0423988 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0416664 |
| NF1 | neurofibromin 1 | -0.0416149 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.041497 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0413565 |
| FLNB | filamin B, beta | -0.0412334 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0410555 |
| CCNY | cyclin Y | -0.0404986 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.04043 |
| ASPH | aspartate beta-hydroxylase | -0.0402787 |
| CDCP1 | CUB domain containing protein 1 | -0.0402125 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0389221 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0383481 |
| POTEF | POTE ankyrin domain family, member F | -0.037344 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0373207 |
| PCED1B | PC-esterase domain containing 1B | -0.0363572 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0361625 |
| FMNL2 | formin-like 2 | -0.0355458 |
| INTS6 | integrator complex subunit 6 | -0.0354222 |
| TPI1 | triosephosphate isomerase 1 | -0.0354203 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0350977 |
| PYGL | phosphorylase, glycogen, liver | -0.0343533 |
| UBC | ubiquitin C | -0.0342996 |
| SDC4 | syndecan 4 | -0.0339109 |
| SETX | senataxin | -0.033908 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0333997 |
| DHX34 | DEAH (Asp-Glu-Ala-His) box polypeptide 34 | -0.0329195 |
| ATG7 | autophagy related 7 | -0.032024 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.031599 |
| SVIL | supervillin | -0.0314455 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0312098 |
| EP300 | E1A binding protein p300 | -0.0308625 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.030604 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.030556 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0303813 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0303778 |
| CUL3 | cullin 3 | -0.0299233 |
| KIF5B | kinesin family member 5B | -0.0298977 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0296452 |
| HM13 | histocompatibility (minor) 13 | -0.0295047 |
| DNER | delta/notch-like EGF repeat containing | -0.0294992 |
| MYO9B | myosin IXB | -0.0293978 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0293466 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0292834 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0292138 |
| PCNX4 | pecanex 4 | -0.0291937 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0290462 |
| EPN2 | epsin 2 | -0.0290262 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0288712 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0288426 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0288244 |
| EXOC6B | exocyst complex component 6B | -0.028705 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0282834 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0281025 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0280917 |
| RPS27A | ribosomal protein S27a | -0.0279952 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0279841 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0278341 |
| NLK | nemo-like kinase | -0.0278037 |
| IER3 | immediate early response 3 | -0.0277814 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0276402 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0275806 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0275484 |
| RIOK3 | RIO kinase 3 | -0.0275419 |
