Cobimetinib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cobimetinib perturbation in SW 900 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Cobimetinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.168143
NAMPT nicotinamide phosphoribosyltransferase 0.134885
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.131753
SQSTM1 sequestosome 1 0.115557
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.11445
CANX calnexin 0.0754472
B2M beta-2-microglobulin 0.0678684
HLA-B major histocompatibility complex, class I, B 0.0673907
FTL ferritin, light polypeptide 0.0647972
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0636772
TRIO trio Rho guanine nucleotide exchange factor 0.0636056
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0634898
TPT1 tumor protein, translationally-controlled 1 0.0564092
RPS6 ribosomal protein S6 0.0556827
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0547739
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0521196
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.051308
DST dystonin 0.0499218
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.049011
ENO1 enolase 1, (alpha) 0.0476485
EXT1 exostosin glycosyltransferase 1 0.0465911
IFI16 interferon, gamma-inducible protein 16 0.0456442
PTMA prothymosin, alpha 0.0444839
PELI1 pellino E3 ubiquitin protein ligase 1 0.0442407
TXNIP thioredoxin interacting protein 0.0437928
RNF213 ring finger protein 213 0.0431481
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.041756
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0417332
TXNRD1 thioredoxin reductase 1 0.0416463
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0407335
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0403139
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0386953
ENAH enabled homolog (Drosophila) 0.0379641
RPL37A ribosomal protein L37a 0.0378798
RPS12 ribosomal protein S12 0.0376014
GPC6 glypican 6 0.0370574
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0369756
S100A6 S100 calcium binding protein A6 0.0369431
RACK1 receptor for activated C kinase 1 0.0368536
FAM13A family with sequence similarity 13, member A 0.036575
RPL26 ribosomal protein L26 0.0364583
CFB complement factor B 0.035522
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0352281
SFTPA2 surfactant protein A2 0.0346165
FNDC3B fibronectin type III domain containing 3B 0.0345502
CD109 CD109 molecule 0.0342031
RPL31 ribosomal protein L31 0.0338093
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0336924
OGA O-GlcNAcase 0.0335369
AHR aryl hydrocarbon receptor 0.0330723
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0327536
MXI1 MAX interactor 1, dimerization protein 0.032204
RPS8 ribosomal protein S8 0.0318577
TPI1 triosephosphate isomerase 1 0.0311022
TNS3 tensin 3 0.0310964
RPLP1 ribosomal protein, large, P1 0.0309969
LRMDA leucine rich melanocyte differentiation associated 0.0308869
OSMR oncostatin M receptor 0.030882
EIF1 eukaryotic translation initiation factor 1 0.0308454
FN1 fibronectin 1 0.0308393
NAP1L1 nucleosome assembly protein 1-like 1 0.03057
ZMYND8 zinc finger, MYND-type containing 8 0.0304953
KLHL5 kelch-like family member 5 0.0303795
AOPEP aminopeptidase O (putative) 0.0300476
MKI67 marker of proliferation Ki-67 0.0299069
RPS27 ribosomal protein S27 0.0295899
NIPBL Nipped-B homolog (Drosophila) 0.0293303
RPL34 ribosomal protein L34 0.0286555
RUNX2 runt-related transcription factor 2 0.028569
LIFR leukemia inhibitory factor receptor alpha 0.0284461
SOS1 son of sevenless homolog 1 (Drosophila) 0.028419
RPS3 ribosomal protein S3 0.0283714
TGFB2 transforming growth factor, beta 2 0.028348
S100A10 S100 calcium binding protein A10 0.0283115
RPS29 ribosomal protein S29 0.0280803
PTGR1 prostaglandin reductase 1 0.0280516
IFI27 interferon, alpha-inducible protein 27 0.0279882
RPL12 ribosomal protein L12 0.0278077
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0278066
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0277131
MYOF myoferlin 0.0274631
KDM3A lysine (K)-specific demethylase 3A 0.027246
TAS2R14 taste receptor, type 2, member 14 0.0269979
GNAS GNAS complex locus 0.0269052
TMSB10 thymosin beta 10 0.026792
BIRC3 baculoviral IAP repeat containing 3 0.026695
PXMP2 peroxisomal membrane protein 2, 22kDa 0.0263313
ZNF292 zinc finger protein 292 0.0262901
SOD2 superoxide dismutase 2, mitochondrial 0.0262838
SMYD3 SET and MYND domain containing 3 0.0259896
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0258794
RPS19 ribosomal protein S19 0.025676
VIM vimentin 0.0254023
RPL23 ribosomal protein L23 0.02514
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0249622
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0245709
FMN1 formin 1 0.0245373
RPL37 ribosomal protein L37 0.0244835
LMNA lamin A/C 0.0244539
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0243944

decreased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 -0.176464
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.105246
NRG1 neuregulin 1 -0.105244
ITGA1 integrin, alpha 1 -0.100747
CXCL8 chemokine (C-X-C motif) ligand 8 -0.072369
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0706916
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0664696
VEGFA vascular endothelial growth factor A -0.0610202
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0596358
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0564592
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0563543
NDRG1 N-myc downstream regulated 1 -0.0519722
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0514933
NRP1 neuropilin 1 -0.0483565
EGR1 early growth response 1 -0.0395547
FTH1 ferritin, heavy polypeptide 1 -0.0395416
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0357901
PELO pelota homolog (Drosophila) -0.0337628
TMEM156 transmembrane protein 156 -0.0333733
HPCAL1 hippocalcin-like 1 -0.0329269
TOP1 topoisomerase (DNA) I -0.0320932
FAM3C family with sequence similarity 3, member C -0.0320801
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0305927
NPAS2 neuronal PAS domain protein 2 -0.0295492
VMP1 vacuole membrane protein 1 -0.0294726
SHB Src homology 2 domain containing adaptor protein B -0.0286846
HIPK2 homeodomain interacting protein kinase 2 -0.0276053
HMGA1 high mobility group AT-hook 1 -0.0274927
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.027462
KSR1 kinase suppressor of ras 1 -0.0270215
GRB10 growth factor receptor-bound protein 10 -0.0268753
COPA coatomer protein complex, subunit alpha -0.0259491
FOSL1 FOS-like antigen 1 -0.0243519
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0242751
AKAP9 A kinase (PRKA) anchor protein 9 -0.0240595
SYT1 synaptotagmin I -0.0237211
AHRR aryl-hydrocarbon receptor repressor -0.0234796
AGO2 argonaute RISC catalytic component 2 -0.0234364
LRP5 low density lipoprotein receptor-related protein 5 -0.0231758
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0230857
MYO10 myosin X -0.0229741
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0224779
WWTR1 WW domain containing transcription regulator 1 -0.0224612
CDCP1 CUB domain containing protein 1 -0.0223051
ACTN1 actinin, alpha 1 -0.0222692
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0221904
DOCK5 dedicator of cytokinesis 5 -0.0221578
ETV1 ets variant 1 -0.0217523
TMEM165 transmembrane protein 165 -0.0217394
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0217209
PDLIM5 PDZ and LIM domain 5 -0.0216915
FHL2 four and a half LIM domains 2 -0.0216573
MCTP2 multiple C2 domains, transmembrane 2 -0.0216252
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0215764
TJP1 tight junction protein 1 -0.0215025
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0214958
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.021222
NUP58 nucleoporin 58 -0.0210553
CD44 CD44 molecule (Indian blood group) -0.0209406
MEF2D myocyte enhancer factor 2D -0.020849
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0204353
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -0.0201109
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0200582
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0200246
ASPH aspartate beta-hydroxylase -0.019525
POTEF POTE ankyrin domain family, member F -0.0194695
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0190391
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0190169
GLIS3 GLIS family zinc finger 3 -0.0188787
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0188239
ZFYVE28 zinc finger, FYVE domain containing 28 -0.0187715
NTN4 netrin 4 -0.0186845
UBASH3B ubiquitin associated and SH3 domain containing B -0.0185231
ARF4 ADP-ribosylation factor 4 -0.0184602
MSN moesin -0.0183877
PHC2 polyhomeotic homolog 2 (Drosophila) -0.0181837
PTK2 protein tyrosine kinase 2 -0.0180741
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0180572
ENO2 enolase 2 (gamma, neuronal) -0.0180034
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.017815
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0175699
MCL1 myeloid cell leukemia 1 -0.017504
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -0.017441
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -0.0174132
EREG epiregulin -0.0173794
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0171091
BRD2 bromodomain containing 2 -0.0169855
GOLGA4 golgin A4 -0.0169224
TSC22D1 TSC22 domain family, member 1 -0.0166955
TGFB1 transforming growth factor, beta 1 -0.0166025
PCBP2 poly(rC) binding protein 2 -0.0163501
GPATCH2L G patch domain containing 2-like -0.0162378
SEC24D SEC24 family member D -0.0161227
AGRN agrin -0.0161114
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0161061
DUSP6 dual specificity phosphatase 6 -0.0160674
ATP11A ATPase, class VI, type 11A -0.0156428
GATAD2B GATA zinc finger domain containing 2B -0.0155477
MIDEAS mitotic deacetylase associated SANT domain protein -0.0155367
NDEL1 nudE neurodevelopment protein 1-like 1 -0.0155218