Cocaine Abuse Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A substance abuse that involves the recurring use of cocaine despite negative consequences. (Human Disease Ontology, DOID_809)
External Link https://www.disgenet.org/browser/0/1/0/C0009171
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Genes

124 genes associated with the disease Cocaine Abuse in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACTB actin, beta
ADRA1A adrenoceptor alpha 1A
ADRBK2 adrenergic, beta, receptor kinase 2
AGO2 argonaute RISC catalytic component 2
ANKK1 ankyrin repeat and kinase domain containing 1
APOL2 apolipoprotein L, 2
ARC activity-regulated cytoskeleton-associated protein
ATP9B ATPase, class II, type 9B
BCHE butyrylcholinesterase
BDNF brain-derived neurotrophic factor
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK4 calcium/calmodulin-dependent protein kinase IV
CARTPT CART prepropeptide
CCKBR cholecystokinin B receptor
CCSER1 coiled-coil serine-rich protein 1
CDC25B cell division cycle 25B
CES1 carboxylesterase 1
CES2 carboxylesterase 2
CHRM5 cholinergic receptor, muscarinic 5
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CNR1 cannabinoid receptor 1 (brain)
COL21A1 collagen, type XXI, alpha 1
COMT catechol-O-methyltransferase
CREB1 cAMP responsive element binding protein 1
CRH corticotropin releasing hormone
CRHBP corticotropin releasing hormone binding protein
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DNAH8 dynein, axonemal, heavy chain 8
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
EGR1 early growth response 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGF2 fibroblast growth factor 2 (basic)
FKBP5 FK506 binding protein 5
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GCC1 GRIP and coiled-coil domain containing 1
GDNF glial cell derived neurotrophic factor
GHRL ghrelin/obestatin prepropeptide
GPBAR1 G protein-coupled bile acid receptor 1
GPHN gephyrin
GPSM1 G-protein signaling modulator 1
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRM5 glutamate receptor, metabotropic 5
HCRT hypocretin (orexin) neuropeptide precursor
HCRTR1 hypocretin (orexin) receptor 1
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HOMER1 homer scaffolding protein 1
HOMER2 homer scaffolding protein 2
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
ICE2 interactor of little elongation complex ELL subunit 2
ILK integrin-linked kinase
INTS8 integrator complex subunit 8
JUND jun D proto-oncogene
KLHL5 kelch-like family member 5
LRRC7 leucine rich repeat containing 7
LRRK2 leucine-rich repeat kinase 2
MANEA mannosidase, endo-alpha
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MECP2 methyl CpG binding protein 2
NGF nerve growth factor (beta polypeptide)
NPS neuropeptide S
NPY neuropeptide Y
NPY2R neuropeptide Y receptor Y2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPRK1 opioid receptor, kappa 1
OPRM1 opioid receptor, mu 1
PDYN prodynorphin
PITX3 paired-like homeodomain 3
PLP1 proteolipid protein 1
POMC proopiomelanocortin
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRL prolactin
PRMT6 protein arginine methyltransferase 6
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RHOA ras homolog family member A
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RUNX2 runt-related transcription factor 2
SCARB1 scavenger receptor class B, member 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SMAD5 SMAD family member 5
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SRCIN1 SRC kinase signaling inhibitor 1
SYT13 synaptotagmin XIII
TACR3 tachykinin receptor 3
TENM3 teneurin transmembrane protein 3
TYK2 tyrosine kinase 2
WEE1 WEE1 G2 checkpoint kinase