Cocaine Dependence Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A drug dependence that is a psychological dependency on the regular use of cocaine. (Human Disease Ontology, DOID_9975)
External Link https://www.disgenet.org/browser/0/1/0/C0600427
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Genes

174 genes associated with the disease Cocaine Dependence in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADRA1A adrenoceptor alpha 1A
ADRB2 adrenoceptor beta 2, surface
ADRBK2 adrenergic, beta, receptor kinase 2
AGO2 argonaute RISC catalytic component 2
ANKK1 ankyrin repeat and kinase domain containing 1
APOL2 apolipoprotein L, 2
ARC activity-regulated cytoskeleton-associated protein
ARRB2 arrestin, beta 2
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
ATP9B ATPase, class II, type 9B
AVP arginine vasopressin
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCHE butyrylcholinesterase
BDNF brain-derived neurotrophic factor
BRD4 bromodomain containing 4
C1QL2 complement component 1, q subcomponent-like 2
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALY calcyon neuron-specific vesicular protein
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK4 calcium/calmodulin-dependent protein kinase IV
CARTPT CART prepropeptide
CCKBR cholecystokinin B receptor
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCSER1 coiled-coil serine-rich protein 1
CD160 CD160 molecule
CDK5 cyclin-dependent kinase 5
CDNF cerebral dopamine neurotrophic factor
CES1 carboxylesterase 1
CES2 carboxylesterase 2
CHRM4 cholinergic receptor, muscarinic 4
CHRM5 cholinergic receptor, muscarinic 5
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CLOCK clock circadian regulator
CNR1 cannabinoid receptor 1 (brain)
COL21A1 collagen, type XXI, alpha 1
COMT catechol-O-methyltransferase
CREB1 cAMP responsive element binding protein 1
CRH corticotropin releasing hormone
CRHBP corticotropin releasing hormone binding protein
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DNAH8 dynein, axonemal, heavy chain 8
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
EGR1 early growth response 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ESR2 estrogen receptor 2 (ER beta)
EXTL3 exostosin-like glycosyltransferase 3
F2RL3 coagulation factor II (thrombin) receptor-like 3
FAM53B family with sequence similarity 53, member B
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGF2 fibroblast growth factor 2 (basic)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GALR1 galanin receptor 1
GCC1 GRIP and coiled-coil domain containing 1
GDNF glial cell derived neurotrophic factor
GHRL ghrelin/obestatin prepropeptide
GLI2 GLI family zinc finger 2
GPHN gephyrin
GPSM1 G-protein signaling modulator 1
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRM2 glutamate receptor, metabotropic 2
GRM5 glutamate receptor, metabotropic 5
GSTP1 glutathione S-transferase pi 1
HCRT hypocretin (orexin) neuropeptide precursor
HCRTR1 hypocretin (orexin) receptor 1
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HMGB1 high mobility group box 1
HOMER1 homer scaffolding protein 1
HOMER2 homer scaffolding protein 2
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
ICE2 interactor of little elongation complex ELL subunit 2
ILK integrin-linked kinase
JUND jun D proto-oncogene
KALRN kalirin, RhoGEF kinase
KCTD20 potassium channel tetramerization domain containing 20
KLHL5 kelch-like family member 5
LEP leptin
LRRC7 leucine rich repeat containing 7
MANEA mannosidase, endo-alpha
MAOA monoamine oxidase A
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MC4R melanocortin 4 receptor
MECP2 methyl CpG binding protein 2
MGC57346-CRHR1 MGC57346-CRHR1 readthrough
NCOR2 nuclear receptor corepressor 2
NCS1 neuronal calcium sensor 1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NGF nerve growth factor (beta polypeptide)
NLN neurolysin (metallopeptidase M3 family)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPS neuropeptide S
NPY neuropeptide Y
NPY2R neuropeptide Y receptor Y2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NSF N-ethylmaleimide-sensitive factor
NTNG1 netrin G1
NTNG2 netrin G2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPN4 opsin 4
OPRD1 opioid receptor, delta 1
OPRK1 opioid receptor, kappa 1
OPRL1 opiate receptor-like 1
OPRM1 opioid receptor, mu 1
OR3A2 olfactory receptor, family 3, subfamily A, member 2
PAWR PRKC, apoptosis, WT1, regulator
PDYN prodynorphin
PER1 period circadian clock 1
PER2 period circadian clock 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PNOC prepronociceptin
POMC proopiomelanocortin
PRL prolactin
PRMT6 protein arginine methyltransferase 6
RGS4 regulator of G-protein signaling 4
RHOA ras homolog family member A
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RUNX2 runt-related transcription factor 2
SCARB1 scavenger receptor class B, member 1
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SMAD5 SMAD family member 5
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRCIN1 SRC kinase signaling inhibitor 1
SST somatostatin
STK38 serine/threonine kinase 38
SYT13 synaptotagmin XIII
TAAR1 trace amine associated receptor 1
TAC1 tachykinin, precursor 1
TACR3 tachykinin receptor 3
TENM3 teneurin transmembrane protein 3
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TPH2 tryptophan hydroxylase 2
TYK2 tyrosine kinase 2
UMOD uromodulin
WDHD1 WD repeat and HMG-box DNA binding protein 1