Cocaine addiction Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Drug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic system that projects from the ventral tegmental area (VTA) of the midbrain to the nucleus accumbens (NAc), and to other forebrain sites, is the major substrate of reward and reinforcement for both natural rewards and addictive drugs. Cocaine binds strongly to the dopamine-reuptake transporter, preventing the reuptake of dopamine into the nerve terminal. Because of this blocking effect, dopamine remains at high concentrations in the synapse and continues to affect adjacent neurons, producing the characteristic cocaine "high." Activated D1 receptor activates the PKA signaling pathway, and this pathway plays a critical role in mediating the behavioral responses to cocaine administration. Cocaine-induced neuroadaptations, including dopamine depletion, may underlie craving and hedonic dysregulation. (Kyoto Encyclopedia of Genes and Genomes, hsa05030)
External Link https://www.kegg.jp/entry/hsa05030
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Genes

48 proteins participating in the Cocaine addiction pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ADCY5 adenylate cyclase 5
ATF4 activating transcription factor 4
ATF6B activating transcription factor 6 beta
BDNF brain-derived neurotrophic factor
CDK5 cyclin-dependent kinase 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CREB1 cAMP responsive element binding protein 1
CREB3L1 cAMP responsive element binding protein 3-like 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CREB3L3 cAMP responsive element binding protein 3-like 3
CREB3L4 cAMP responsive element binding protein 3-like 4
CREB5 cAMP responsive element binding protein 5
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GDNF glial cell derived neurotrophic factor
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAS GNAS complex locus
GPRIN1 G protein regulated inducer of neurite outgrowth 1
GPSM1 G-protein signaling modulator 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
GRM2 glutamate receptor, metabotropic 2
GRM3 glutamate receptor, metabotropic 3
JUN jun proto-oncogene
LLGL1 lethal giant larvae homolog 1 (Drosophila)
MAOA monoamine oxidase A
MAOB monoamine oxidase B
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
PDYN prodynorphin
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCA protein kinase C, alpha
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RGS9BP regulator of G protein signaling 9 binding protein
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
TH tyrosine hydroxylase