Cocaine Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca. (Chemical Entities of Biological Interest Ontology, CHEBI_27958)
External Link http://ctdbase.org/detail.go?type=chem&acc=D003042
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Genes

251 genes/proteins interacting with the chemical Cocaine from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
AANAT aralkylamine N-acetyltransferase
ACO2 aconitase 2, mitochondrial
ADORA1 adenosine A1 receptor
ADRA1B adrenoceptor alpha 1B
ADRB1 adrenoceptor beta 1
AGO2 argonaute RISC catalytic component 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APCS amyloid P component, serum
ARC activity-regulated cytoskeleton-associated protein
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ARPP21 cAMP-regulated phosphoprotein, 21kDa
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP9B ATPase, class II, type 9B
BAX BCL2-associated X protein
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CCKBR cholecystokinin B receptor
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCSER1 coiled-coil serine-rich protein 1
CD81 CD81 molecule
CDK5 cyclin-dependent kinase 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CES1 carboxylesterase 1
CES2 carboxylesterase 2
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CKB creatine kinase, brain
CKM creatine kinase, muscle
CNR1 cannabinoid receptor 1 (brain)
COL21A1 collagen, type XXI, alpha 1
CREB1 cAMP responsive element binding protein 1
CRH corticotropin releasing hormone
CRHR1 corticotropin releasing hormone receptor 1
CRP C-reactive protein, pentraxin-related
CRTC1 CREB regulated transcription coactivator 1
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
CYCS cytochrome c, somatic
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DLG4 discs, large homolog 4 (Drosophila)
DNAH8 dynein, axonemal, heavy chain 8
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPYSL2 dihydropyrimidinase-like 2
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRP2 dystrophin related protein 2
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EDNRA endothelin receptor type A
EGR1 early growth response 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ELANE elastase, neutrophil expressed
ENO2 enolase 2 (gamma, neuronal)
EPHB1 EPH receptor B1
ERN1 endoplasmic reticulum to nucleus signaling 1
FADD Fas (TNFRSF6)-associated via death domain
FAHD2A fumarylacetoacetate hydrolase domain containing 2A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAL galanin/GMAP prepropeptide
GFAP glial fibrillary acidic protein
GH1 growth hormone 1
GJB1 gap junction protein, beta 1, 32kDa
GJD2 gap junction protein, delta 2, 36kDa
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GPSM1 G-protein signaling modulator 1
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRIK1 glutamate receptor, ionotropic, kainate 1
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIK3 glutamate receptor, ionotropic, kainate 3
GRIK5 glutamate receptor, ionotropic, kainate 5
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
GRIP1 glutamate receptor interacting protein 1
GRM2 glutamate receptor, metabotropic 2
GRM3 glutamate receptor, metabotropic 3
GRM5 glutamate receptor, metabotropic 5
GSK3B glycogen synthase kinase 3 beta
GSTO1 glutathione S-transferase omega 1
HCRTR2 hypocretin (orexin) receptor 2
HDAC5 histone deacetylase 5
HDC histidine decarboxylase
HOMER1 homer scaffolding protein 1
HOMER2 homer scaffolding protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
ICE2 interactor of little elongation complex ELL subunit 2
IFNG interferon, gamma
IL10 interleukin 10
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL4 interleukin 4
IL6 interleukin 6
ILK integrin-linked kinase
INS insulin
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLHL5 kelch-like family member 5
LRRC7 leucine rich repeat containing 7
MANEA mannosidase, endo-alpha
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MBD1 methyl-CpG binding domain protein 1
MBP myelin basic protein
MECP2 methyl CpG binding protein 2
MIR132 microRNA 132
MIR212 microRNA 212
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
NCF1 neutrophil cytosolic factor 1
NCF2 neutrophil cytosolic factor 2
NCF4 neutrophil cytosolic factor 4, 40kDa
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
NEFH neurofilament, heavy polypeptide
NEO1 neogenin 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGF nerve growth factor (beta polypeptide)
NME2 NME/NM23 nucleoside diphosphate kinase 2
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPAS2 neuronal PAS domain protein 2
NPPA natriuretic peptide A
NPPC natriuretic peptide C
NPTX2 neuronal pentraxin II
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTS neurotensin
OPRD1 opioid receptor, delta 1
OPRK1 opioid receptor, kappa 1
OPRM1 opioid receptor, mu 1
OXTR oxytocin receptor
PARP1 poly (ADP-ribose) polymerase 1
PCDH8 protocadherin 8
PDIA3 protein disulfide isomerase family A, member 3
PDYN prodynorphin
PEBP1 phosphatidylethanolamine binding protein 1
PER1 period circadian clock 1
PER2 period circadian clock 2
PER3 period circadian clock 3
PF4 platelet factor 4
PGR progesterone receptor
PITX3 paired-like homeodomain 3
PLCG1 phospholipase C, gamma 1
POMC proopiomelanocortin
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PRDX2 peroxiredoxin 2
PRDX5 peroxiredoxin 5
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PRKCE protein kinase C, epsilon
PRL prolactin
PRTN3 proteinase 3
PTK2B protein tyrosine kinase 2 beta
PVALB parvalbumin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RECK reversion-inducing-cysteine-rich protein with kazal motifs
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
S100B S100 calcium binding protein B
SCG2 secretogranin II
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SP1 Sp1 transcription factor
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYN1 synapsin I
SYN2 synapsin II
SYN3 synapsin III
SYT13 synaptotagmin XIII
SYT7 synaptotagmin VII
TENM3 teneurin transmembrane protein 3
TH tyrosine hydroxylase
TKT transketolase
TNF tumor necrosis factor
TNNI3 troponin I type 3 (cardiac)
TYK2 tyrosine kinase 2
VWF von Willebrand factor
XDH xanthine dehydrogenase