Collagen degradation Gene Set

Dataset Reactome Pathways 2014
Category structural or functional annotations
Type pathway
Description The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. (Gene Ontology, GO_0030574)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-1442490
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Genes

38 proteins participating in the Collagen degradation pathway from the Reactome Pathways dataset.

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
ADAM9 ADAM metallopeptidase domain 9
COL12A1 collagen, type XII, alpha 1
COL13A1 collagen, type XIII, alpha 1
COL14A1 collagen, type XIV, alpha 1
COL15A1 collagen, type XV, alpha 1
COL16A1 collagen, type XVI, alpha 1
COL17A1 collagen, type XVII, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL19A1 collagen, type XIX, alpha 1
COL23A1 collagen, type XXIII, alpha 1
COL25A1 collagen, type XXV, alpha 1
COL26A1 collagen, type XXVI, alpha 1
COL9A1 collagen, type IX, alpha 1
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
CTSB cathepsin B
CTSD cathepsin D
CTSK cathepsin K
CTSL cathepsin L
ELANE elastase, neutrophil expressed
FURIN furin (paired basic amino acid cleaving enzyme)
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP11 matrix metallopeptidase 11
MMP12 matrix metallopeptidase 12
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMP19 matrix metallopeptidase 19
MMP2 matrix metallopeptidase 2
MMP20 matrix metallopeptidase 20
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
PRSS2 protease, serine, 2 (trypsin 2)