| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/139169018 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Compound-1a relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.95 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.89 |
| ANK2 | ankyrin 2, neuronal | 0.79 |
| CES3 | carboxylesterase 3 | 0.73 |
| DZIP3 | DAZ interacting zinc finger protein 3 | 0.6 |
| ZNF746 | zinc finger protein 746 | 0.58 |
| ZNF776 | zinc finger protein 776 | 0.57 |
| ALPK3 | alpha-kinase 3 | 0.56 |
| B3GLCT | beta 3-glucosyltransferase | 0.55 |
| FANCL | Fanconi anemia, complementation group L | 0.54 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.53 |
| ZG16B | zymogen granule protein 16B | 0.52 |
| SYTL4 | synaptotagmin-like 4 | 0.49 |
| STK16 | serine/threonine kinase 16 | 0.48 |
| MAGEA6 | melanoma antigen family A6 | 0.47 |
| GAS2L3 | growth arrest-specific 2 like 3 | 0.47 |
| SP4 | Sp4 transcription factor | 0.46 |
| TLCD4 | TLC domain containing 4 | 0.46 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.46 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.45 |
| ASF1B | anti-silencing function 1B histone chaperone | 0.44 |
| DIPK2A | divergent protein kinase domain 2A | 0.44 |
| THAP9 | THAP domain containing 9 | 0.43 |
| COMMD9 | COMM domain containing 9 | 0.43 |
| CDC25B | cell division cycle 25B | 0.42 |
| ZNF268 | zinc finger protein 268 | 0.42 |
| FBXO33 | F-box protein 33 | 0.42 |
| GALK2 | galactokinase 2 | 0.42 |
| KIFC3 | kinesin family member C3 | 0.41 |
| OTUD7B | OTU deubiquitinase 7B | 0.41 |
| E2F2 | E2F transcription factor 2 | 0.4 |
| ILRUN | inflammation and lipid regulator with UBA-like and NBR1-like domains | 0.4 |
| PIP5K1C | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma | 0.39 |
| C5ORF51 | chromosome 5 open reading frame 51 | 0.39 |
| ASAP3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 | 0.39 |
| KLHL2 | kelch-like family member 2 | 0.39 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.39 |
| PLGRKT | plasminogen receptor, C-terminal lysine transmembrane protein | 0.38 |
| WDR25 | WD repeat domain 25 | 0.38 |
| DENND5B | DENN/MADD domain containing 5B | 0.37 |
| OIP5 | Opa interacting protein 5 | 0.37 |
| TRIM37 | tripartite motif containing 37 | 0.37 |
| CDK18 | cyclin-dependent kinase 18 | 0.37 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.36 |
| OTUD3 | OTU deubiquitinase 3 | 0.36 |
| DEPDC1 | DEP domain containing 1 | 0.36 |
| HLA-F | major histocompatibility complex, class I, F | 0.35 |
| ALG8 | ALG8, alpha-1,3-glucosyltransferase | 0.34 |
| CEPT1 | choline/ethanolamine phosphotransferase 1 | 0.34 |
| GIGYF1 | GRB10 interacting GYF protein 1 | 0.33 |
| PEX13 | peroxisomal biogenesis factor 13 | 0.33 |
| EHF | ets homologous factor | 0.33 |
| SLC25A33 | solute carrier family 25 (pyrimidine nucleotide carrier), member 33 | 0.33 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 0.33 |
| RSPRY1 | ring finger and SPRY domain containing 1 | 0.32 |
| PAQR4 | progestin and adipoQ receptor family member IV | 0.32 |
| TBPL1 | TBP-like 1 | 0.32 |
| MICU2 | mitochondrial calcium uptake 2 | 0.32 |
| USP38 | ubiquitin specific peptidase 38 | 0.32 |
| C20ORF27 | chromosome 20 open reading frame 27 | 0.32 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | 0.32 |
| ATG13 | autophagy related 13 | 0.32 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 0.32 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | 0.31 |
| MBD4 | methyl-CpG binding domain protein 4 | 0.31 |
| TRAPPC1 | trafficking protein particle complex 1 | 0.31 |
| MT-ATP6 | ATP synthase F0 subunit 6 | 0.31 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.31 |
| ZNF395 | zinc finger protein 395 | 0.31 |
| SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | 0.31 |
| WRB | tryptophan rich basic protein | 0.31 |
| FAM162A | family with sequence similarity 162, member A | 0.31 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.3 |
| SPRTN | SprT-like N-terminal domain | 0.3 |
| RREB1 | ras responsive element binding protein 1 | 0.3 |
| DHRS1 | dehydrogenase/reductase (SDR family) member 1 | 0.3 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | 0.3 |
| SERPINC1 | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 0.3 |
| INPP5A | inositol polyphosphate-5-phosphatase, 40kDa | 0.3 |
| MYZAP | myocardial zonula adherens protein | 0.3 |
| ANKRD26 | ankyrin repeat domain 26 | 0.3 |
| GALNT11 | polypeptide N-acetylgalactosaminyltransferase 11 | 0.3 |
| LIPA | lipase A, lysosomal acid, cholesterol esterase | 0.3 |
| SP2 | Sp2 transcription factor | 0.3 |
| MYH7 | myosin, heavy chain 7, cardiac muscle, beta | 0.29 |
| CCDC84 | coiled-coil domain containing 84 | 0.29 |
| ABHD3 | abhydrolase domain containing 3 | 0.29 |
| TINF2 | TERF1 (TRF1)-interacting nuclear factor 2 | 0.29 |
| NHEJ1 | nonhomologous end-joining factor 1 | 0.29 |
| LDLRAP1 | low density lipoprotein receptor adaptor protein 1 | 0.29 |
| ZNF714 | zinc finger protein 714 | 0.29 |
| CDK3 | cyclin-dependent kinase 3 | 0.29 |
| SCAPER | S-phase cyclin A-associated protein in the ER | 0.29 |
| JMJD8 | jumonji domain containing 8 | 0.28 |
| EXTL2 | exostosin-like glycosyltransferase 2 | 0.28 |
| TMEM128 | transmembrane protein 128 | 0.28 |
| MAGEF1 | melanoma antigen family F1 | 0.28 |
| MOB3A | MOB kinase activator 3A | 0.28 |
| EPHB2 | EPH receptor B2 | 0.28 |
| BRSK1 | BR serine/threonine kinase 1 | 0.27 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPP25 | ribonuclease P/MRP 25kDa subunit | -1.09 |
| CDC37 | cell division cycle 37 | -0.85 |
| ACTB | actin, beta | -0.8 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.8 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.73 |
| ACTBL2 | actin, beta-like 2 | -0.72 |
| SESN2 | sestrin 2 | -0.7 |
| PABPN1 | poly(A) binding protein, nuclear 1 | -0.69 |
| TSTD1 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 | -0.66 |
| CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa | -0.65 |
| TEAD3 | TEA domain family member 3 | -0.64 |
| KLHL42 | kelch-like family member 42 | -0.63 |
| HMGN4 | high mobility group nucleosomal binding domain 4 | -0.61 |
| FADS1 | fatty acid desaturase 1 | -0.6 |
| UBXN8 | UBX domain protein 8 | -0.59 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.59 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -0.59 |
| PIP | prolactin-induced protein | -0.59 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.57 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.56 |
| EIF2B4 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | -0.54 |
| JMJD4 | jumonji domain containing 4 | -0.53 |
| C5ORF30 | chromosome 5 open reading frame 30 | -0.51 |
| XYLB | xylulokinase homolog (H. influenzae) | -0.51 |
| DES | desmin | -0.51 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | -0.5 |
| XDH | xanthine dehydrogenase | -0.5 |
| RPL15 | ribosomal protein L15 | -0.49 |
| RSL24D1 | ribosomal L24 domain containing 1 | -0.49 |
| ERICH5 | glutamate-rich 5 | -0.48 |
| CMC1 | C-x(9)-C motif containing 1 | -0.48 |
| PLEKHN1 | pleckstrin homology domain containing, family N member 1 | -0.47 |
| FGD1 | FYVE, RhoGEF and PH domain containing 1 | -0.47 |
| SUMO2 | small ubiquitin-like modifier 2 | -0.47 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.47 |
| ZNF749 | zinc finger protein 749 | -0.46 |
| PLEC | plectin | -0.45 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.44 |
| SIRT2 | sirtuin 2 | -0.44 |
| RBMXL2 | RNA binding motif protein, X-linked-like 2 | -0.43 |
| TMEM237 | transmembrane protein 237 | -0.43 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.43 |
| PRR3 | proline rich 3 | -0.43 |
| SFN | stratifin | -0.42 |
| NOP53 | NOP53 ribosome biogenesis factor | -0.42 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.41 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | -0.41 |
| OTC | ornithine carbamoyltransferase | -0.41 |
| HSPA1L | heat shock 70kDa protein 1-like | -0.41 |
| FIG4 | FIG4 phosphoinositide 5-phosphatase | -0.4 |
| EIF1AX | eukaryotic translation initiation factor 1A, X-linked | -0.39 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.39 |
| BNIP2 | BCL2/adenovirus E1B 19kDa interacting protein 2 | -0.38 |
| HGH1 | HGH1 homolog (S. cerevisiae) | -0.38 |
| ZYX | zyxin | -0.38 |
| CCAR2 | cell cycle and apoptosis regulator 2 | -0.37 |
| RCE1 | Ras converting CAAX endopeptidase 1 | -0.37 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.37 |
| FBXO42 | F-box protein 42 | -0.37 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.36 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | -0.36 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | -0.36 |
| MNX1 | motor neuron and pancreas homeobox 1 | -0.36 |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | -0.35 |
| TARDBP | TAR DNA binding protein | -0.35 |
| NDUFB9 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa | -0.35 |
| ZBTB39 | zinc finger and BTB domain containing 39 | -0.35 |
| EIF4E | eukaryotic translation initiation factor 4E | -0.34 |
| PKM | pyruvate kinase, muscle | -0.34 |
| GALT | galactose-1-phosphate uridylyltransferase | -0.33 |
| ICAM5 | intercellular adhesion molecule 5, telencephalin | -0.33 |
| S100A14 | S100 calcium binding protein A14 | -0.33 |
| UBL7 | ubiquitin-like 7 | -0.33 |
| MOB2 | MOB kinase activator 2 | -0.32 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.32 |
| RAB30 | RAB30, member RAS oncogene family | -0.32 |
| C19ORF54 | chromosome 19 open reading frame 54 | -0.32 |
| PFDN4 | prefoldin subunit 4 | -0.32 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.32 |
| YBX1 | Y box binding protein 1 | -0.31 |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | -0.31 |
| FTL | ferritin, light polypeptide | -0.31 |
| SPATA13 | spermatogenesis associated 13 | -0.31 |
| ACP1 | acid phosphatase 1, soluble | -0.31 |
| HMGXB3 | HMG box domain containing 3 | -0.31 |
| CSRP1 | cysteine and glycine-rich protein 1 | -0.31 |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | -0.31 |
| S100A10 | S100 calcium binding protein A10 | -0.31 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.3 |
| UPF3A | UPF3 regulator of nonsense transcripts homolog A (yeast) | -0.3 |
| ATP5MF | ATP synthase membrane subunit f | -0.3 |
| TMEM41B | transmembrane protein 41B | -0.3 |
| PDGFC | platelet derived growth factor C | -0.3 |
| NIPA2 | non imprinted in Prader-Willi/Angelman syndrome 2 | -0.3 |
| FOSL1 | FOS-like antigen 1 | -0.3 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.3 |
| TPM4 | tropomyosin 4 | -0.3 |
| TRIM35 | tripartite motif containing 35 | -0.3 |
| EEF1AKMT4-ECE2 | EEF1AKMT4-ECE2 readthrough | -0.3 |
