Conjunctivitis Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Conjunctivitis is a conjunctival disease described as a inflammation of the conjunctiva, the outermost layer of the eye and the inner surface of the eyelids, which is most commonly due to an allergic reaction or an infection (usually viral, but sometimes bacterial. Fungal infections are rare and occur mainly in people who use corticosteroid eye drops for a long time or have eye injuries involving vegetable matter. Newborns are particularly susceptible to eye infections, which they acquire from organisms in the mother's birth canal (neonatal conjunctivitis. (Human Disease Ontology, DOID_6195)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D003231
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Genes

290 genes/proteins associated with the disease Conjunctivitis from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 2.04463
IL6 interleukin 6 2.01431
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.9794
BCL2 B-cell CLL/lymphoma 2 1.91586
IL1B interleukin 1, beta 1.8991
TNF tumor necrosis factor 1.88638
BAX BCL2-associated X protein 1.87842
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.8662
S100A9 S100 calcium binding protein A9 1.86288
CXCL8 chemokine (C-X-C motif) ligand 8 1.85098
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.84622
H2AFX H2A histone family, member X 1.8418
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.83806
CCND1 cyclin D1 1.82254
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.77316
CCL2 chemokine (C-C motif) ligand 2 1.77101
PARP1 poly (ADP-ribose) polymerase 1 1.72571
CAT catalase 1.71993
RB1 retinoblastoma 1 1.71789
GSTP1 glutathione S-transferase pi 1 1.7142
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.7045
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.69805
FAS Fas cell surface death receptor 1.69805
CCL3 chemokine (C-C motif) ligand 3 1.69534
C3 complement component 3 1.68718
MMP9 matrix metallopeptidase 9 1.68422
DDIT3 DNA-damage-inducible transcript 3 1.6759
BIRC5 baculoviral IAP repeat containing 5 1.64011
HSPA8 heat shock 70kDa protein 8 1.63653
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.63428
TP53 tumor protein p53 1.63227
GSTM1 glutathione S-transferase mu 1 1.60664
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.59873
IL1A interleukin 1, alpha 1.58936
F3 coagulation factor III (thromboplastin, tissue factor) 1.57971
NQO1 NAD(P)H dehydrogenase, quinone 1 1.57306
PPARG peroxisome proliferator-activated receptor gamma 1.57257
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.56804
TGFB1 transforming growth factor, beta 1 1.56755
CAV1 caveolin 1, caveolae protein, 22kDa 1.56706
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.55329
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.55206
CCL5 chemokine (C-C motif) ligand 5 1.54937
S100A4 S100 calcium binding protein A4 1.54864
SPON1 spondin 1, extracellular matrix protein 1.54281
VEGFA vascular endothelial growth factor A 1.54086
IGFBP3 insulin-like growth factor binding protein 3 1.53579
HMOX1 heme oxygenase 1 1.53357
CCL11 chemokine (C-C motif) ligand 11 1.52914
NOS2 nitric oxide synthase 2, inducible 1.52161
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.51683
BMP4 bone morphogenetic protein 4 1.51582
BCL2L1 BCL2-like 1 1.5143
IL10 interleukin 10 1.507
VCAM1 vascular cell adhesion molecule 1 1.50273
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.49635
MCL1 myeloid cell leukemia 1 1.49508
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.4933
FOS FBJ murine osteosarcoma viral oncogene homolog 1.4871
PCNA proliferating cell nuclear antigen 1.48684
THBS1 thrombospondin 1 1.48505
ANXA2 annexin A2 1.48505
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.47889
CCNG1 cyclin G1 1.47711
ALB albumin 1.4727
ANXA1 annexin A1 1.46781
PRC1 protein regulator of cytokinesis 1 1.46542
GCLM glutamate-cysteine ligase, modifier subunit 1.45458
ATF3 activating transcription factor 3 1.44681
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.44681
FN1 fibronectin 1 1.44681
EGFR epidermal growth factor receptor 1.44246
MAPK3 mitogen-activated protein kinase 3 1.43892
CD44 CD44 molecule (Indian blood group) 1.43293
JUN jun proto-oncogene 1.43184
MAPK1 mitogen-activated protein kinase 1 1.43076
GSR glutathione reductase 1.4294
MMP3 matrix metallopeptidase 3 1.42885
MAPK8 mitogen-activated protein kinase 8 1.4275
PLAU plasminogen activator, urokinase 1.41586
TNC tenascin C 1.41174
CXCL5 chemokine (C-X-C motif) ligand 5 1.41174
SPP1 secreted phosphoprotein 1 1.41008
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.4065
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.40008
SOD1 superoxide dismutase 1, soluble 1.39757
IFNG interferon, gamma 1.39757
GADD45A growth arrest and DNA-damage-inducible, alpha 1.39674
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.38752
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.38612
ICAM1 intercellular adhesion molecule 1 1.38384
MMP1 matrix metallopeptidase 1 1.3827
IL18 interleukin 18 1.37705
GDF15 growth differentiation factor 15 1.37705
TLR4 toll-like receptor 4 1.3736
CLU clusterin 1.36905
CCL7 chemokine (C-C motif) ligand 7 1.36562
APP amyloid beta (A4) precursor protein 1.36476
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.36247
GCLC glutamate-cysteine ligase, catalytic subunit 1.3619
GUCY1B3 guanylate cyclase 1, soluble, beta 3 1.35792
EGR1 early growth response 1 1.35676
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.34955
RAD51 RAD51 recombinase 1.34694
S100A8 S100 calcium binding protein A8 1.34694
TAC1 tachykinin, precursor 1 1.34547
RHOA ras homolog family member A 1.34198
ADM adrenomedullin 1.34024
CXCL10 chemokine (C-X-C motif) ligand 10 1.34024
LHB luteinizing hormone beta polypeptide 1.34024
IGF1 insulin-like growth factor 1 (somatomedin C) 1.3385
CCNE1 cyclin E1 1.33642
PPARA peroxisome proliferator-activated receptor alpha 1.33022
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.32935
ANGPTL4 angiopoietin-like 4 1.32756
NOS3 nitric oxide synthase 3 (endothelial cell) 1.31927
IL1RN interleukin 1 receptor antagonist 1.31837
EDNRB endothelin receptor type B 1.31837
IL4 interleukin 4 1.31807
MAPK14 mitogen-activated protein kinase 14 1.31387
GPX1 glutathione peroxidase 1 1.29812
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.28303
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.28027
CXCL2 chemokine (C-X-C motif) ligand 2 1.27966
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.27689
CP ceruloplasmin (ferroxidase) 1.27626
GATA3 GATA binding protein 3 1.27564
F2 coagulation factor II (thrombin) 1.26978
TYMS thymidylate synthetase 1.26732
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 1.26021
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 1.25619
UNG uracil-DNA glycosylase 1.254
GHR growth hormone receptor 1.25183
CCNB1 cyclin B1 1.25121
COL1A1 collagen, type I, alpha 1 1.24966
GSTT1 glutathione S-transferase theta 1 1.24905
MAP2K1 mitogen-activated protein kinase kinase 1 1.24433
PLIN2 perilipin 2 1.24213
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1.23993
HSPA4 heat shock 70kDa protein 4 1.23993
CTGF connective tissue growth factor 1.23962
PLAT plasminogen activator, tissue 1.23392
LMNA lamin A/C 1.23233
APOE apolipoprotein E 1.23074
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.22884
TFRC transferrin receptor 1.22177
HRAS Harvey rat sarcoma viral oncogene homolog 1.22177
CH25H cholesterol 25-hydroxylase 1.22145
EDN1 endothelin 1 1.21271
STAR steroidogenic acute regulatory protein 1.21108
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 1.21076
SRGN serglycin 1.21076
IGFBP5 insulin-like growth factor binding protein 5 1.20848
MPO myeloperoxidase 1.20784
EDNRA endothelin receptor type A 1.20493
HSPA1A heat shock 70kDa protein 1A 1.20262
HSPB1 heat shock 27kDa protein 1 1.20163
CCL20 chemokine (C-C motif) ligand 20 1.19999
HBEGF heparin-binding EGF-like growth factor 1.19966
POR P450 (cytochrome) oxidoreductase 1.19868
SAA3P serum amyloid A3 pseudogene 1.19737
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.19146
PTGIS prostaglandin I2 (prostacyclin) synthase 1.1908
BID BH3 interacting domain death agonist 1.19047
MAPK9 mitogen-activated protein kinase 9 1.18849
GPX2 glutathione peroxidase 2 1.18652
MMP2 matrix metallopeptidase 2 1.1862
BBC3 BCL2 binding component 3 1.18489
KRT18 keratin 18, type I 1.18359
LMCD1 LIM and cysteine-rich domains 1 1.18159
FBLN1 fibulin 1 1.18159
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 1.17563
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 1.17563
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.17268
PTPRC protein tyrosine phosphatase, receptor type, C 1.17235
RRM2 ribonucleotide reductase M2 1.17101
TGM1 transglutaminase 1 1.16967
HTRA1 HtrA serine peptidase 1 1.16666
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.165
COL3A1 collagen, type III, alpha 1 1.16335
BDNF brain-derived neurotrophic factor 1.16236
RFC3 replication factor C (activator 1) 3, 38kDa 1.16104
HSPA1B heat shock 70kDa protein 1B 1.1607
BAK1 BCL2-antagonist/killer 1 1.15933
CNR1 cannabinoid receptor 1 (brain) 1.15357
AREG amphiregulin 1.15324
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 1.15055
DBP D site of albumin promoter (albumin D-box) binding protein 1.15022
CXCR4 chemokine (C-X-C motif) receptor 4 1.14919
CTSB cathepsin B 1.1437
LCN2 lipocalin 2 1.14336
F7 coagulation factor VII (serum prothrombin conversion accelerator) 1.14234
DUSP4 dual specificity phosphatase 4 1.14234
BTG2 BTG family, member 2 1.142
ATF4 activating transcription factor 4 1.14064
AKAP12 A kinase (PRKA) anchor protein 12 1.13963
TIMP1 TIMP metallopeptidase inhibitor 1 1.13552
AOX1 aldehyde oxidase 1 1.13245
KIF23 kinesin family member 23 1.13211
TYMP thymidine phosphorylase 1.13211
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.13075
CFD complement factor D (adipsin) 1.12973
SESN1 sestrin 1 1.12703
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 1.12495
COL1A2 collagen, type I, alpha 2 1.12495
CXCL12 chemokine (C-X-C motif) ligand 12 1.12357
FASLG Fas ligand (TNF superfamily, member 6) 1.12254
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.11877
IL13 interleukin 13 1.11741
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 1.11571
AKT2 v-akt murine thymoma viral oncogene homolog 2 1.11081
DKK1 dickkopf WNT signaling pathway inhibitor 1 1.10424
IL33R interleukin 33 receptor 1.10424
KLK6 kallikrein-related peptidase 6 1.10353
THBD thrombomodulin 1.10211
IL1R2 interleukin 1 receptor, type II 1.10211
NFIL3 nuclear factor, interleukin 3 regulated 1.09998
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.09681
MARCKS myristoylated alanine-rich protein kinase C substrate 1.09541
CD38 CD38 molecule 1.09366
FSHB follicle stimulating hormone, beta polypeptide 1.09083
NGF nerve growth factor (beta polypeptide) 1.09011
MKI67 marker of proliferation Ki-67 1.08868
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.08833
FLRT2 fibronectin leucine rich transmembrane protein 2 1.08407
ANXA3 annexin A3 1.08161
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 1.08126
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.08091
BAD BCL2-associated agonist of cell death 1.07875
CKB creatine kinase, brain 1.0734
G0S2 G0/G1 switch 2 1.06952
ATF2 activating transcription factor 2 1.06771
CD93 CD93 molecule 1.06625
ARG2 arginase 2 1.0637
NOX4 NADPH oxidase 4 1.0637
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.06261
UBE2C ubiquitin-conjugating enzyme E2C 1.06188
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 1.06044
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.05972
ODC1 ornithine decarboxylase 1 1.05828
DUSP1 dual specificity phosphatase 1 1.05757
EEF2 eukaryotic translation elongation factor 2 1.05648
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.05648
KCTD12 potassium channel tetramerization domain containing 12 1.05386
INHBA inhibin, beta A 1.05274
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.05237
F2R coagulation factor II (thrombin) receptor 1.05126
CD28 CD28 molecule 1.04978
TK1 thymidine kinase 1, soluble 1.04941
TAGLN transgelin 1.04904
PTPRG protein tyrosine phosphatase, receptor type, G 1.04611
CTSL cathepsin L 1.04538
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.04201
IRF6 interferon regulatory factor 6 1.04201
TTN titin 1.03827
ADCY7 adenylate cyclase 7 1.03789
GADD45G growth arrest and DNA-damage-inducible, gamma 1.03678
KLF6 Kruppel-like factor 6 1.03678
PRNP prion protein 1.0353
CCNA2 cyclin A2 1.03235
RASA1 RAS p21 protein activator (GTPase activating protein) 1 1.03122
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 1.03122
CD4 CD4 molecule 1.03084
LGALS3 lectin, galactoside-binding, soluble, 3 1.03009
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.02858
FANCI Fanconi anemia, complementation group I 1.02746
CCL19 chemokine (C-C motif) ligand 19 1.02708
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 1.0241
ERBB4 erb-b2 receptor tyrosine kinase 4 1.02373
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.02336
CDK2 cyclin-dependent kinase 2 1.02299
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 1.02188
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.02188
DCT dopachrome tautomerase 1.02077
RGS1 regulator of G-protein signaling 1 1.0204
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 1.01966
TIMP3 TIMP metallopeptidase inhibitor 3 1.0189
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.01739
COL4A2 collagen, type IV, alpha 2 1.01701
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 1.01701
APAF1 apoptotic peptidase activating factor 1 1.01587
TRIM2 tripartite motif containing 2 1.01361
MRAS muscle RAS oncogene homolog 1.01361
RPS27L ribosomal protein S27-like 1.01361
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 1.01249
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.01212
CYBB cytochrome b-245, beta polypeptide 1.01099
NBN nibrin 1.01025
CHUK conserved helix-loop-helix ubiquitous kinase 1.01025
IL2RB interleukin 2 receptor, beta 1.01025