Constipation Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D003248
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Genes

298 genes/proteins associated with the disease Constipation from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
GCG glucagon 2.88009
PON1 paraoxonase 1 2.88009
POMC proopiomelanocortin 2.88009
GPBAR1 G protein-coupled bile acid receptor 1 2.88009
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.46045
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.38636
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.37272
TNF tumor necrosis factor 2.28655
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.26822
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.21815
PRL prolactin 2.19379
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.13633
BAX BCL2-associated X protein 2.09333
MAPK1 mitogen-activated protein kinase 1 2.07429
MAPK3 mitogen-activated protein kinase 3 2.04358
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.99236
CAT catalase 1.97361
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.96847
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.96714
VEGFA vascular endothelial growth factor A 1.96314
FAS Fas cell surface death receptor 1.93521
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.9082
BCL2 B-cell CLL/lymphoma 2 1.90804
IL10 interleukin 10 1.88885
GSTP1 glutathione S-transferase pi 1 1.88819
IL6 interleukin 6 1.84446
FOS FBJ murine osteosarcoma viral oncogene homolog 1.8409
PARP1 poly (ADP-ribose) polymerase 1 1.83646
IL1B interleukin 1, beta 1.83219
ICAM1 intercellular adhesion molecule 1 1.81848
TAGLN transgelin 1.8113
NUPR1 nuclear protein, transcriptional regulator, 1 1.80491
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.78606
CCL2 chemokine (C-C motif) ligand 2 1.77394
BDNF brain-derived neurotrophic factor 1.77179
TP53 tumor protein p53 1.76617
IL2 interleukin 2 1.73129
SOD2 superoxide dismutase 2, mitochondrial 1.71748
MAPK14 mitogen-activated protein kinase 14 1.70698
SOD1 superoxide dismutase 1, soluble 1.70285
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.69659
IL1A interleukin 1, alpha 1.6606
RRM2 ribonucleotide reductase M2 1.65731
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.65
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.64393
HMOX1 heme oxygenase 1 1.64033
CXCL8 chemokine (C-X-C motif) ligand 8 1.63966
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.63049
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.6192
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.59896
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.58959
EGR1 early growth response 1 1.58724
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.58607
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.58514
FABP1 fatty acid binding protein 1, liver 1.56899
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.55182
DRD2 dopamine receptor D2 1.54815
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.53868
IL4 interleukin 4 1.53357
F3 coagulation factor III (thromboplastin, tissue factor) 1.53061
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.52262
MAPK8 mitogen-activated protein kinase 8 1.51456
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.50298
CES2 carboxylesterase 2 1.5012
INHBE inhibin, beta E 1.48531
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.47787
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 1.4766
BCL2L1 BCL2-like 1 1.4753
GADD45A growth arrest and DNA-damage-inducible, alpha 1.47089
DDIT3 DNA-damage-inducible transcript 3 1.46909
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.46754
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.45936
CDK2 cyclin-dependent kinase 2 1.4522
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.44845
ATF3 activating transcription factor 3 1.44681
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.44681
HMGB2 high mobility group box 2 1.44572
NPY neuropeptide Y 1.4449
JUN jun proto-oncogene 1.43809
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.43646
TOP2A topoisomerase (DNA) II alpha 170kDa 1.43374
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.42723
VIM vimentin 1.42321
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.41748
MCL1 myeloid cell leukemia 1 1.41559
CTSL cathepsin L 1.4098
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.4098
GSK3B glycogen synthase kinase 3 beta 1.40568
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.40486
CTSD cathepsin D 1.39897
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.39646
TGFB1 transforming growth factor, beta 1 1.39563
TIMP1 TIMP metallopeptidase inhibitor 1 1.39507
TAC1 tachykinin, precursor 1 1.39086
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.38669
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.37676
REN renin 1.3759
PHYH phytanoyl-CoA 2-hydroxylase 1.37446
FNDC4 fibronectin type III domain containing 4 1.36361
GUSB glucuronidase, beta 1.36047
CCNB1 cyclin B1 1.35877
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.35705
VCAM1 vascular cell adhesion molecule 1 1.35415
BIRC2 baculoviral IAP repeat containing 2 1.35299
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.35069
C10ORF10 chromosome 10 open reading frame 10 1.34897
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.34869
CFLAR CASP8 and FADD-like apoptosis regulator 1.34869
CYCS cytochrome c, somatic 1.33938
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.33612
OPRM1 opioid receptor, mu 1 1.33228
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.3314
BAK1 BCL2-antagonist/killer 1 1.33022
INS insulin 1.32816
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.32756
BECN1 beclin 1, autophagy related 1.32667
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.32577
CDK1 cyclin-dependent kinase 1 1.3231
NPPA natriuretic peptide A 1.31927
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.31626
FASLG Fas ligand (TNF superfamily, member 6) 1.31596
ERBB2 erb-b2 receptor tyrosine kinase 2 1.31237
ATF5 activating transcription factor 5 1.31
SREBF1 sterol regulatory element binding transcription factor 1 1.31
IFNG interferon, gamma 1.30604
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.30482
BIRC5 baculoviral IAP repeat containing 5 1.28919
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.28827
TH tyrosine hydroxylase 1.28796
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.28641
HSPB1 heat shock 27kDa protein 1 1.28518
AVP arginine vasopressin 1.28333
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.28241
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.28058
LHB luteinizing hormone beta polypeptide 1.27936
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.27875
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.27533
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.26825
GAL galanin/GMAP prepropeptide 1.26545
CCL3 chemokine (C-C motif) ligand 3 1.26421
CCND1 cyclin D1 1.26421
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 1.25899
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.25807
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.25463
STMN1 stathmin 1 1.25369
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 1.25214
COMT catechol-O-methyltransferase 1.25152
BIRC3 baculoviral IAP repeat containing 3 1.25152
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.25152
EPO erythropoietin 1.24935
SRGN serglycin 1.24718
ADRB1 adrenoceptor beta 1 1.24496
CALCA calcitonin-related polypeptide alpha 1.24307
NBN nibrin 1.24275
BUB3 BUB3 mitotic checkpoint protein 1.23552
PCNA proliferating cell nuclear antigen 1.23328
MKI67 marker of proliferation Ki-67 1.23201
CRH corticotropin releasing hormone 1.23011
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 1.22948
GPX1 glutathione peroxidase 1 1.22177
H2AFX H2A histone family, member X 1.21919
CCL5 chemokine (C-C motif) ligand 5 1.21791
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.21631
BRCA1 breast cancer 1, early onset 1.2137
DRD1 dopamine receptor D1 1.21173
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.20881
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.20816
FGF2 fibroblast growth factor 2 (basic) 1.20687
OPRK1 opioid receptor, kappa 1 1.20687
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.2046
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.20064
MPO myeloperoxidase 1.199
CREM cAMP responsive element modulator 1.19868
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.19672
GEM GTP binding protein overexpressed in skeletal muscle 1.19279
ODC1 ornithine decarboxylase 1 1.18915
GAMT guanidinoacetate N-methyltransferase 1.18882
MGMT O-6-methylguanine-DNA methyltransferase 1.18849
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 1.18521
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.18456
DPYD dihydropyrimidine dehydrogenase 1.18326
CD44 CD44 molecule (Indian blood group) 1.17728
SREBF2 sterol regulatory element binding transcription factor 2 1.17431
NOS2 nitric oxide synthase 2, inducible 1.17399
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.17202
OXT oxytocin/neurophysin I prepropeptide 1.17067
NFE2L2 nuclear factor, erythroid 2-like 2 1.16933
NKAIN1 Na+/K+ transporting ATPase interacting 1 1.167
PRKCD protein kinase C, delta 1.15933
MAPK9 mitogen-activated protein kinase 9 1.15695
EGF epidermal growth factor 1.1556
GFAP glial fibrillary acidic protein 1.15425
PLAU plasminogen activator, urokinase 1.15425
EGR2 early growth response 2 1.15391
MMP9 matrix metallopeptidase 9 1.15089
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.14954
TYMS thymidylate synthetase 1.14747
RB1 retinoblastoma 1 1.14678
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 1.14302
PRC1 protein regulator of cytokinesis 1 1.14302
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.13655
FN1 fibronectin 1 1.13449
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.13347
EPCAM epithelial cell adhesion molecule 1.13041
WEE1 WEE1 G2 checkpoint kinase 1.12737
PENK proenkephalin 1.12703
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.12599
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.12288
CYP3A cytochrome P450, family 3, subfamily A 1.12117
BBC3 BCL2 binding component 3 1.12048
THBS1 thrombospondin 1 1.12048
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.11809
FSHB follicle stimulating hormone, beta polypeptide 1.11809
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.11775
NGF nerve growth factor (beta polypeptide) 1.11639
AKT2 v-akt murine thymoma viral oncogene homolog 2 1.11501
CREB1 cAMP responsive element binding protein 1 1.11466
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.11186
HSPA8 heat shock 70kDa protein 8 1.11151
TEX261 testis expressed 261 1.11011
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.10803
DKK1 dickkopf WNT signaling pathway inhibitor 1 1.10596
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.10596
HPN hepsin 1.10388
COL4A1 collagen, type IV, alpha 1 1.10317
GDF15 growth differentiation factor 15 1.10246
IRS1 insulin receptor substrate 1 1.10175
CCNB2 cyclin B2 1.09786
TLR4 toll-like receptor 4 1.09786
CCND3 cyclin D3 1.09786
TRIM2 tripartite motif containing 2 1.09471
GJA1 gap junction protein, alpha 1, 43kDa 1.09471
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.09471
RBM17 RNA binding motif protein 17 1.09366
PDYN prodynorphin 1.0919
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.0919
SPON1 spondin 1, extracellular matrix protein 1.09011
IL1RN interleukin 1 receptor antagonist 1.08975
HSPA1B heat shock 70kDa protein 1B 1.08797
HRAS Harvey rat sarcoma viral oncogene homolog 1.08584
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.08301
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.08196
SGK1 serum/glucocorticoid regulated kinase 1 1.07625
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 1.07518
UNG uracil-DNA glycosylase 1.07518
ZNF552 zinc finger protein 552 1.07234
DUSP1 dual specificity phosphatase 1 1.07163
DIABLO diablo, IAP-binding mitochondrial protein 1.06987
MELK maternal embryonic leucine zipper kinase 1.06952
EGFR epidermal growth factor receptor 1.06808
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.06225
FASN fatty acid synthase 1.06152
HSPA1A heat shock 70kDa protein 1A 1.06008
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.05936
BIRC7 baculoviral IAP repeat containing 7 1.05685
C3 complement component 3 1.05573
POR P450 (cytochrome) oxidoreductase 1.05461
CD14 CD14 molecule 1.05386
HRH1 histamine receptor H1 1.052
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 1.052
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 1.05015
NAIP NLR family, apoptosis inhibitory protein 1.04978
ALB albumin 1.04978
MSMO1 methylsterol monooxygenase 1 1.04941
CCNE1 cyclin E1 1.04757
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.04239
C1QA complement component 1, q subcomponent, A chain 1.04201
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.04201
PSAP prosaposin 1.04201
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.03976
NQO1 NAD(P)H dehydrogenase, quinone 1 1.03827
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.03827
IL23A interleukin 23, alpha subunit p19 1.03827
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 1.03678
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 1.03678
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.03456
CP ceruloplasmin (ferroxidase) 1.03419
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.03159
RELN reelin 1.03084
STK4 serine/threonine kinase 4 1.03046
KDM4B lysine (K)-specific demethylase 4B 1.03009
GSTM1 glutathione S-transferase mu 1 1.02971
GNAS GNAS complex locus 1.02971
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 1.02971
CASP12 caspase 12 (gene/pseudogene) 1.02971
ERP29 endoplasmic reticulum protein 29 1.02746
OAT ornithine aminotransferase 1.02708
F2 coagulation factor II (thrombin) 1.02559
TPM1 tropomyosin 1 (alpha) 1.02485
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.02485
CCAR1 cell division cycle and apoptosis regulator 1 1.0241
TCF7 transcription factor 7 (T-cell specific, HMG-box) 1.02373
IL1R1 interleukin 1 receptor, type I 1.0204
PF4 platelet factor 4 1.0204
IL12B interleukin 12B 1.02003
LOX lysyl oxidase 1.01587
GADD45G growth arrest and DNA-damage-inducible, gamma 1.01549
S100A9 S100 calcium binding protein A9 1.01361