Coronavirus disease - COVID-19 Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory infection that is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infects alveolar epithelial cells [mainly alveolar epithelial type 2 (AEC2) cells] through the angiotensin-converting enzyme 2 (ACE2) receptor. Upon the occupancy of ACE2 by SARS-CoV-2, the increased serum level of free Angiotensin II (Ang II) due to a reduction of ACE2-mediated degradation promotes activation of the NF-kappa B pathway via Ang II type 1 receptor (AT1R), followed by interleukin-6 (IL-6) production. SARS-CoV-2 also activates the innate immune system; macrophage stimulation triggers the overproduction of pro-inflammatory cytokines, including IL-6, and the "cytokine storm", which results in systemic inflammatory response syndrome and multiple organ failure. The combined effects of complement activation, dysregulated neutrophilia, endothelial injury, and hypercoagulability appear to be intertwined to drive the severe features of COVID-19. (Kyoto Encyclopedia of Genes and Genomes, hsa05171)
External Link https://www.kegg.jp/entry/hsa05171
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Genes

231 proteins participating in the Coronavirus disease - COVID-19 pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ADAM17 ADAM metallopeptidase domain 17
ADAR adenosine deaminase, RNA-specific
AGTR1 angiotensin II receptor, type 1
AKR1C1 aldo-keto reductase family 1, member C1
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C1QC complement component 1, q subcomponent, C chain
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
C3AR1 complement component 3a receptor 1
C4A complement component 4A (Rodgers blood group)
C4B complement component 4B (Chido blood group)
C4B_2 complement component 4B (Chido blood group), copy 2
C5 complement component 5
C5AR1 complement component 5a receptor 1
C8A complement component 8, alpha polypeptide
C8B complement component 8, beta polypeptide
C8G complement component 8, gamma polypeptide
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CFB complement factor B
CGAS cyclic GMP-AMP synthase
CHUK conserved helix-loop-helix ubiquitous kinase
CLSTN1 calsyntenin 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYBB cytochrome b-245, beta polypeptide
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
F13A1 coagulation factor XIII, A1 polypeptide
F13B coagulation factor XIII, B polypeptide
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FOS FBJ murine osteosarcoma viral oncogene homolog
HBEGF heparin-binding EGF-like growth factor
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
IFIH1 interferon induced with helicase C domain 1
IFNA1 interferon, alpha 1
IFNA10 interferon, alpha 10
IFNA13 interferon, alpha 13
IFNA14 interferon, alpha 14
IFNA16 interferon, alpha 16
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IFNA21 interferon, alpha 21
IFNA4 interferon, alpha 4
IFNA5 interferon, alpha 5
IFNA6 interferon, alpha 6
IFNA7 interferon, alpha 7
IFNA8 interferon, alpha 8
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNB1 interferon, beta 1, fibroblast
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL12A interleukin 12A
IL12B interleukin 12B
IL1B interleukin 1, beta
IL2 interleukin 2
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK4 interleukin-1 receptor-associated kinase 4
IRF3 interferon regulatory factor 3
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
JAK1 Janus kinase 1
JUN jun proto-oncogene
LNCEGFL7OS lncRNA EGFL7 opposite strand
LOC102724971 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MASP2 mannan-binding lectin serine peptidase 2
MAVS mitochondrial antiviral signaling protein
MBL2 mannose-binding lectin (protein C) 2, soluble
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MRPL13 mitochondrial ribosomal protein L13
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MYD88 myeloid differentiation primary response 88
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRP3 NLR family, pyrin domain containing 3
NRP1 neuropilin 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIKFYVE phosphoinositide kinase, FYVE finger containing
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PMPCB peptidase (mitochondrial processing) beta
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCG protein kinase C, gamma
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RIGI RNA sensor RIG-I
RPL10A ribosomal protein L10a
RPL10L ribosomal protein L10-like
RPL11 ribosomal protein L11
RPL12 ribosomal protein L12
RPL13A ribosomal protein L13a
RPL14 ribosomal protein L14
RPL15 ribosomal protein L15
RPL17-C18ORF32 RPL17-C18orf32 readthrough
RPL18 ribosomal protein L18
RPL18A ribosomal protein L18a
RPL19 ribosomal protein L19
RPL21 ribosomal protein L21
RPL22 ribosomal protein L22
RPL22L1 ribosomal protein L22-like 1
RPL23 ribosomal protein L23
RPL23A ribosomal protein L23a
RPL26 ribosomal protein L26
RPL26L1 ribosomal protein L26-like 1
RPL27 ribosomal protein L27
RPL27A ribosomal protein L27a
RPL28 ribosomal protein L28
RPL29 ribosomal protein L29
RPL3 ribosomal protein L3
RPL30 ribosomal protein L30
RPL31 ribosomal protein L31
RPL32 ribosomal protein L32
RPL34 ribosomal protein L34
RPL35 ribosomal protein L35
RPL35A ribosomal protein L35a
RPL36 ribosomal protein L36
RPL36A ribosomal protein L36a
RPL36A-HNRNPH2 RPL36A-HNRNPH2 readthrough
RPL36AL ribosomal protein L36a-like
RPL37 ribosomal protein L37
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPL39 ribosomal protein L39
RPL3L ribosomal protein L3-like
RPL4 ribosomal protein L4
RPL41 ribosomal protein L41
RPL5 ribosomal protein L5
RPL6 ribosomal protein L6
RPL7 ribosomal protein L7
RPL7A ribosomal protein L7a
RPL8 ribosomal protein L8
RPL9 ribosomal protein L9
RPLP0 ribosomal protein, large, P0
RPLP1 ribosomal protein, large, P1
RPLP2 ribosomal protein, large, P2
RPS10 ribosomal protein S10
RPS10-NUDT3 RPS10-NUDT3 readthrough
RPS11 ribosomal protein S11
RPS12 ribosomal protein S12
RPS13 ribosomal protein S13
RPS14 ribosomal protein S14
RPS15 ribosomal protein S15
RPS15A ribosomal protein S15a
RPS16 ribosomal protein S16
RPS17 ribosomal protein S17
RPS18 ribosomal protein S18
RPS19 ribosomal protein S19
RPS2 ribosomal protein S2
RPS20 ribosomal protein S20
RPS21 ribosomal protein S21
RPS23 ribosomal protein S23
RPS24 ribosomal protein S24
RPS25 ribosomal protein S25
RPS26 ribosomal protein S26
RPS27 ribosomal protein S27
RPS27A ribosomal protein S27a
RPS27L ribosomal protein S27-like
RPS28 ribosomal protein S28
RPS29 ribosomal protein S29
RPS3 ribosomal protein S3
RPS3A ribosomal protein S3A
RPS4X ribosomal protein S4, X-linked
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS4Y2 ribosomal protein S4, Y-linked 2
RPS5 ribosomal protein S5
RPS6 ribosomal protein S6
RPS7 ribosomal protein S7
RPS8 ribosomal protein S8
RPS9 ribosomal protein S9
RPSA ribosomal protein SA
RPSA2 ribosomal protein SA 2
RSL24D1 ribosomal L24 domain containing 1
SELENOP selenoprotein P
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STING1 stimulator of interferon response cGAMP interactor 1
SYK spleen tyrosine kinase
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TBK1 TANK-binding kinase 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TMPRSS2 transmembrane protease, serine 2
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRAF3 TNF receptor-associated factor 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TTF2 transcription termination factor, RNA polymerase II
TYK2 tyrosine kinase 2
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
VWF von Willebrand factor