Cough Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. (Human Phenotype Ontology, HP_0012735)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D003371
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Genes

242 genes/proteins associated with the disease Cough from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
KNG1 kininogen 1 2.88009
ACE angiotensin I converting enzyme 2.88009
TNF tumor necrosis factor 2.34559
IL6 interleukin 6 2.2634
REN renin 2.23623
CCL2 chemokine (C-C motif) ligand 2 2.2351
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.21908
IL1B interleukin 1, beta 2.19573
ICAM1 intercellular adhesion molecule 1 2.16027
CXCL8 chemokine (C-X-C motif) ligand 8 2.15996
IFNG interferon, gamma 2.14894
VCAM1 vascular cell adhesion molecule 1 2.13942
FOS FBJ murine osteosarcoma viral oncogene homolog 2.1308
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.13046
IL10 interleukin 10 2.1253
TGFB1 transforming growth factor, beta 1 2.12333
EDN1 endothelin 1 2.10519
MAPK1 mitogen-activated protein kinase 1 2.05545
MPO myeloperoxidase 2.0508
MAPK3 mitogen-activated protein kinase 3 2.02006
BAX BCL2-associated X protein 2.01636
BCL2 B-cell CLL/lymphoma 2 2.01554
FAS Fas cell surface death receptor 2.01308
VEGFA vascular endothelial growth factor A 2.00192
CAT catalase 1.97742
IL4 interleukin 4 1.97332
NOS2 nitric oxide synthase 2, inducible 1.96818
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.96625
IL1A interleukin 1, alpha 1.95209
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.93444
NOS3 nitric oxide synthase 3 (endothelial cell) 1.91451
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.8965
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.89601
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.87958
HMOX1 heme oxygenase 1 1.87476
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.86271
NPPA natriuretic peptide A 1.85221
MMP2 matrix metallopeptidase 2 1.84888
JUN jun proto-oncogene 1.82954
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.82708
SOD2 superoxide dismutase 2, mitochondrial 1.81958
TP53 tumor protein p53 1.81775
CCL3 chemokine (C-C motif) ligand 3 1.80548
DDIT3 DNA-damage-inducible transcript 3 1.79694
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.79408
CCL5 chemokine (C-C motif) ligand 5 1.76443
MMP9 matrix metallopeptidase 9 1.74984
IL13 interleukin 13 1.74721
CXCL2 chemokine (C-X-C motif) ligand 2 1.74501
NPPB natriuretic peptide B 1.73353
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.72884
FASLG Fas ligand (TNF superfamily, member 6) 1.68697
DUSP1 dual specificity phosphatase 1 1.67072
TIMP1 TIMP metallopeptidase inhibitor 1 1.6606
CYBB cytochrome b-245, beta polypeptide 1.64461
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.62153
MAPK14 mitogen-activated protein kinase 14 1.62036
GSR glutathione reductase 1.61201
MAPK8 mitogen-activated protein kinase 8 1.60944
IL5 interleukin 5 1.60874
TLR4 toll-like receptor 4 1.60454
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.59896
ALB albumin 1.59778
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1 1.58701
IL2 interleukin 2 1.58398
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.58113
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.57042
TRPA1 transient receptor potential cation channel, subfamily A, member 1 1.56875
GSTP1 glutathione S-transferase pi 1 1.56214
ACTA2 actin, alpha 2, smooth muscle, aorta 1.5555
BID BH3 interacting domain death agonist 1.5528
AGTR1 angiotensin II receptor, type 1 1.54523
CYBA cytochrome b-245, alpha polypeptide 1.54354
COL1A1 collagen, type I, alpha 1 1.53772
CALCA calcitonin-related polypeptide alpha 1.53407
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.53184
CRP C-reactive protein, pentraxin-related 1.52642
CYCS cytochrome c, somatic 1.52161
OPRM1 opioid receptor, mu 1 1.51405
CREB1 cAMP responsive element binding protein 1 1.5103
NCF1 neutrophil cytosolic factor 1 1.50473
SOD1 superoxide dismutase 1, soluble 1.48608
SPP1 secreted phosphoprotein 1 1.48196
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.48017
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.47426
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.45883
GFAP glial fibrillary acidic protein 1.4575
NFE2L2 nuclear factor, erythroid 2-like 2 1.45299
ADRB2 adrenoceptor beta 2, surface 1.443
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.43864
IL12B interleukin 12B 1.43239
ATF3 activating transcription factor 3 1.4313
FN1 fibronectin 1 1.4313
BAG3 BCL2-associated athanogene 3 1.42101
CTGF connective tissue growth factor 1.41505
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.41451
EGR1 early growth response 1 1.41202
COL3A1 collagen, type III, alpha 1 1.40732
OPRK1 opioid receptor, kappa 1 1.39952
FGF2 fibroblast growth factor 2 (basic) 1.39591
MCL1 myeloid cell leukemia 1 1.3903
LEP leptin 1.38918
NOX4 NADPH oxidase 4 1.38185
CCL11 chemokine (C-C motif) ligand 11 1.37189
CD44 CD44 molecule (Indian blood group) 1.36848
TAC1 tachykinin, precursor 1 1.36677
CXCL10 chemokine (C-X-C motif) ligand 10 1.36019
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 1.35589
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.35242
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 1.34606
SELL selectin L 1.33966
NQO1 NAD(P)H dehydrogenase, quinone 1 1.33199
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.33022
PRKCB protein kinase C, beta 1.32251
ADM adrenomedullin 1.31416
GPX1 glutathione peroxidase 1 1.30543
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.29996
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.28672
CCND1 cyclin D1 1.28119
PPARA peroxisome proliferator-activated receptor alpha 1.27782
PTGIS prostaglandin I2 (prostacyclin) synthase 1.2772
CXCL5 chemokine (C-X-C motif) ligand 5 1.27595
ADIPOQ adiponectin, C1Q and collagen domain containing 1.26917
S100A4 S100 calcium binding protein A4 1.26825
GADD45A growth arrest and DNA-damage-inducible, alpha 1.26144
IL2RA interleukin 2 receptor, alpha 1.26052
ATF4 activating transcription factor 4 1.25838
TH tyrosine hydroxylase 1.25713
HSPA1A heat shock 70kDa protein 1A 1.25557
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.25557
BDKRB1 bradykinin receptor B1 1.25432
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.24591
CCNE1 cyclin E1 1.2437
FOSL1 FOS-like antigen 1 1.24118
MAPK9 mitogen-activated protein kinase 9 1.23743
PPARG peroxisome proliferator-activated receptor gamma 1.23712
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.23616
CASP4 caspase 4, apoptosis-related cysteine peptidase 1.23424
PRL prolactin 1.23233
PLAU plasminogen activator, urokinase 1.2279
GSTM1 glutathione S-transferase mu 1 1.22664
AGTR2 angiotensin II receptor, type 2 1.22599
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.22436
PCNA proliferating cell nuclear antigen 1.21855
EDNRA endothelin receptor type A 1.2137
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.21304
OPRD1 opioid receptor, delta 1 1.21271
CCL4 chemokine (C-C motif) ligand 4 1.20978
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.20784
BCL2L1 BCL2-like 1 1.20654
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.20622
PDGFB platelet-derived growth factor beta polypeptide 1.20295
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.20064
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.19639
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 1.19574
ADRB1 adrenoceptor beta 1 1.1862
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.18424
BDKRB2 bradykinin receptor B2 1.1786
PARP1 poly (ADP-ribose) polymerase 1 1.17596
TXN thioredoxin 1.17431
APOE apolipoprotein E 1.17366
CD68 CD68 molecule 1.17268
CCL19 chemokine (C-C motif) ligand 19 1.166
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.1607
EGFR epidermal growth factor receptor 1.15967
NPY neuropeptide Y 1.15899
EDNRB endothelin receptor type B 1.15899
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.1556
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 1.15055
SELE selectin E 1.14954
STAR steroidogenic acute regulatory protein 1.1485
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.14816
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.14713
ACO2 aconitase 2, mitochondrial 1.14507
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.14473
RAMP2 receptor (G protein-coupled) activity modifying protein 2 1.14438
F3 coagulation factor III (thromboplastin, tissue factor) 1.14234
SDAD1 SDA1 domain containing 1 1.13929
IL12A interleukin 12A 1.13862
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.13484
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.13279
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.13211
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.12906
KIF20B kinesin family member 20B 1.12805
CCR2 chemokine (C-C motif) receptor 2 1.12495
RB1 retinoblastoma 1 1.12461
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 1.12426
CCL22 chemokine (C-C motif) ligand 22 1.12391
IL7 interleukin 7 1.11255
GCLM glutamate-cysteine ligase, modifier subunit 1.10872
TXNRD1 thioredoxin reductase 1 1.10734
GCLC glutamate-cysteine ligase, catalytic subunit 1.10596
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 1.10527
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.09857
SFTPB surfactant protein B 1.09786
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 1.09751
BDNF brain-derived neurotrophic factor 1.08584
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.08549
AVP arginine vasopressin 1.08549
RNASE3 ribonuclease, RNase A family, 3 1.08407
BIRC3 baculoviral IAP repeat containing 3 1.08231
INS insulin 1.08019
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 1.07875
S100A9 S100 calcium binding protein A9 1.07875
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.07875
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 1.07875
PHLDA2 pleckstrin homology-like domain, family A, member 2 1.07732
PF4 platelet factor 4 1.07732
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.07482
CES2 carboxylesterase 2 1.07447
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 1.07411
AQP4 aquaporin 4 1.06442
TBX21 T-box 21 1.06188
GSK3B glycogen synthase kinase 3 beta 1.0608
PRKCE protein kinase C, epsilon 1.05972
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.05793
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 1.05498
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.05423
GPX2 glutathione peroxidase 2 1.05386
GDF15 growth differentiation factor 15 1.05274
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 1.05052
CPN1 carboxypeptidase N, polypeptide 1 1.05052
TGFA transforming growth factor, alpha 1.04574
STAT1 signal transducer and activator of transcription 1, 91kDa 1.04538
GJA1 gap junction protein, alpha 1, 43kDa 1.04538
BIRC5 baculoviral IAP repeat containing 5 1.04427
PRDX1 peroxiredoxin 1 1.03976
GAST gastrin 1.03976
GAL galanin/GMAP prepropeptide 1.03678
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.03382
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 1.03345
SRXN1 sulfiredoxin 1 1.03197
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 1.03084
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 1.02783
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.02746
PTHLH parathyroid hormone-like hormone 1.02262
CHEK2 checkpoint kinase 2 1.02262
BAK1 BCL2-antagonist/killer 1 1.0189
COL4A1 collagen, type IV, alpha 1 1.01399
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.01286
INHBE inhibin, beta E 1.01137
HSPB1 heat shock 27kDa protein 1 1.01137