| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Crizotinib (hydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Crizotinib (hydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0940807 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0828314 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.067474 |
| FLNA | filamin A, alpha | 0.0671192 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.06547 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0618712 |
| CANX | calnexin | 0.0606386 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0594954 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0584594 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0537602 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0533962 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.049482 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0454229 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0452054 |
| SEPTIN9 | septin 9 | 0.0451012 |
| APP | amyloid beta (A4) precursor protein | 0.0443702 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0442816 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0434755 |
| SQSTM1 | sequestosome 1 | 0.0393283 |
| LOXL2 | lysyl oxidase-like 2 | 0.0386573 |
| FBN1 | fibrillin 1 | 0.0382289 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0374596 |
| FLNB | filamin B, beta | 0.0368104 |
| CALR | calreticulin | 0.0355956 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0352306 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0347305 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0334578 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0330376 |
| COL3A1 | collagen, type III, alpha 1 | 0.0309988 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0294304 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0293899 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0293832 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0290595 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0288249 |
| L1CAM | L1 cell adhesion molecule | 0.0276035 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0270101 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0269078 |
| NAV2 | neuron navigator 2 | 0.0268376 |
| ARRDC3 | arrestin domain containing 3 | 0.0263252 |
| OGA | O-GlcNAcase | 0.0262626 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0257558 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0250744 |
| LDHA | lactate dehydrogenase A | 0.02477 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0246279 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0241383 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.023774 |
| SBF2 | SET binding factor 2 | 0.0237579 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.0230913 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.022941 |
| VIM | vimentin | 0.0229281 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0229189 |
| HLA-E | major histocompatibility complex, class I, E | 0.0220063 |
| ADM | adrenomedullin | 0.0212808 |
| SH3BP2 | SH3-domain binding protein 2 | 0.0209768 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0207883 |
| CD109 | CD109 molecule | 0.0206036 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0204794 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0203598 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.020249 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0198238 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0198213 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0197891 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0197729 |
| CLU | clusterin | 0.0195174 |
| FAM107B | family with sequence similarity 107, member B | 0.0194221 |
| VEGFA | vascular endothelial growth factor A | 0.0193194 |
| RPS3 | ribosomal protein S3 | 0.0193095 |
| ATP13A3 | ATPase type 13A3 | 0.0191101 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.019103 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0191026 |
| PLEC | plectin | 0.019069 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0186224 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0182589 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0180842 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0178047 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0177859 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0177216 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0176181 |
| DENND5A | DENN/MADD domain containing 5A | 0.0176051 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | 0.0175644 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0171441 |
| OPTN | optineurin | 0.0171115 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0169048 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0168672 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0168267 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0167737 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0166969 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.016624 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0165538 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0163067 |
| BRD2 | bromodomain containing 2 | 0.0162894 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | 0.0162729 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.016182 |
| PML | promyelocytic leukemia | 0.0161732 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0159994 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | 0.015897 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0158563 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0158314 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.015787 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0157857 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.297521 |
| TMSB10 | thymosin beta 10 | -0.178731 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.17648 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.122573 |
| MAP1B | microtubule-associated protein 1B | -0.0913284 |
| S100A10 | S100 calcium binding protein A10 | -0.0872044 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0869662 |
| POTEF | POTE ankyrin domain family, member F | -0.0865719 |
| NAV1 | neuron navigator 1 | -0.0783294 |
| SUCNR1 | succinate receptor 1 | -0.0770671 |
| MT2A | metallothionein 2A | -0.0724349 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0703855 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0701531 |
| PLAT | plasminogen activator, tissue | -0.0680949 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0647722 |
| CDH13 | cadherin 13 | -0.0608809 |
| S100A6 | S100 calcium binding protein A6 | -0.0575339 |
| CSTB | cystatin B (stefin B) | -0.0557283 |
| HLA-B | major histocompatibility complex, class I, B | -0.0555912 |
| FN1 | fibronectin 1 | -0.0528712 |
| B2M | beta-2-microglobulin | -0.0504656 |
| LOX | lysyl oxidase | -0.0451693 |
| TAGLN2 | transgelin 2 | -0.0435995 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0424823 |
| PODXL | podocalyxin-like | -0.0420218 |
| MX2 | MX dynamin-like GTPase 2 | -0.0413029 |
| MT1X | metallothionein 1X | -0.0391111 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0389631 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0382059 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0364195 |
| PRSS23 | protease, serine, 23 | -0.0364138 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0362077 |
| CD44 | CD44 molecule (Indian blood group) | -0.0355938 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0328913 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0326452 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0325079 |
| HLA-C | major histocompatibility complex, class I, C | -0.0324845 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0324467 |
| MEIS2 | Meis homeobox 2 | -0.031872 |
| PFN1 | profilin 1 | -0.0316153 |
| CENPF | centromere protein F, 350/400kDa | -0.0313185 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0306076 |
| CD99 | CD99 molecule | -0.0303275 |
| MYADM | myeloid-associated differentiation marker | -0.0300134 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0297004 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0293935 |
| ASPH | aspartate beta-hydroxylase | -0.0289733 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0283538 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0280609 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0280604 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0280066 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0277865 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.027737 |
| CD59 | CD59 molecule, complement regulatory protein | -0.027657 |
| ACTG1 | actin gamma 1 | -0.0275829 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0275229 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0272606 |
| S100A11 | S100 calcium binding protein A11 | -0.0272506 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0272295 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.0271262 |
| DCLK2 | doublecortin-like kinase 2 | -0.0263545 |
| S100A4 | S100 calcium binding protein A4 | -0.0260357 |
| RPL35A | ribosomal protein L35a | -0.0252773 |
| LRRC17 | leucine rich repeat containing 17 | -0.0251429 |
| KRT81 | keratin 81, type II | -0.0239297 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0234092 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0232574 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0231871 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0230126 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0226216 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0223284 |
| CBX3 | chromobox homolog 3 | -0.022242 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0219985 |
| CDK6 | cyclin-dependent kinase 6 | -0.0219002 |
| SEC61G | Sec61 gamma subunit | -0.0218143 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0217564 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0213818 |
| S100A9 | S100 calcium binding protein A9 | -0.0210931 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0206776 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0203671 |
| CUX1 | cut-like homeobox 1 | -0.020178 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0200188 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0196658 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0195315 |
| LMNA | lamin A/C | -0.0194946 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0194575 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0190162 |
| RPL28 | ribosomal protein L28 | -0.0189926 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0189628 |
| CYTH3 | cytohesin 3 | -0.0189472 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0188211 |
| TPM1 | tropomyosin 1 (alpha) | -0.0186999 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0184796 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0183927 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0183534 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0182815 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0182487 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0179048 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0177961 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0177424 |
