| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Crizotinib (hydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Crizotinib (hydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.401316 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.097799 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0902199 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0805329 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0646855 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0566652 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0546244 |
| ANXA1 | annexin A1 | 0.0535208 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0530297 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0485375 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0434071 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0426638 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0407389 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0390585 |
| CANX | calnexin | 0.0381983 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.036957 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0369539 |
| UBC | ubiquitin C | 0.0363255 |
| MYL12B | myosin, light chain 12B, regulatory | 0.035842 |
| AREG | amphiregulin | 0.0349059 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0347314 |
| TPI1 | triosephosphate isomerase 1 | 0.0345425 |
| S100A6 | S100 calcium binding protein A6 | 0.0344879 |
| RPL7 | ribosomal protein L7 | 0.0344287 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0341976 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0341304 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0335983 |
| EHBP1 | EH domain binding protein 1 | 0.0335472 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0331526 |
| CPNE1 | copine I | 0.0329641 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0324111 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0323036 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0318611 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0316774 |
| DSPP | dentin sialophosphoprotein | 0.0310978 |
| ASPH | aspartate beta-hydroxylase | 0.030994 |
| YEATS2 | YEATS domain containing 2 | 0.0307174 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.030119 |
| ALMS1 | Alstrom syndrome protein 1 | 0.0298832 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0295094 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0291882 |
| RPS4X | ribosomal protein S4, X-linked | 0.0289684 |
| RPL4 | ribosomal protein L4 | 0.028264 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0280892 |
| SERINC1 | serine incorporator 1 | 0.0279116 |
| MKI67 | marker of proliferation Ki-67 | 0.027769 |
| PGK1 | phosphoglycerate kinase 1 | 0.027395 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0273744 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0266759 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0264966 |
| HDLBP | high density lipoprotein binding protein | 0.0263529 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0261684 |
| VCAN | versican | 0.0261431 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0259972 |
| NOP2 | NOP2 nucleolar protein | 0.0258461 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0257564 |
| RPL13A | ribosomal protein L13a | 0.0256245 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0251313 |
| PTMA | prothymosin, alpha | 0.0249159 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0248622 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0248394 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0247578 |
| RAB10 | RAB10, member RAS oncogene family | 0.0244766 |
| RPL14 | ribosomal protein L14 | 0.0244311 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0242899 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0235165 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0235056 |
| CMIP | c-Maf inducing protein | 0.0234689 |
| RPRD1A | regulation of nuclear pre-mRNA domain containing 1A | 0.0233883 |
| TXNRD1 | thioredoxin reductase 1 | 0.0232471 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.023002 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0226308 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0225855 |
| PRKCE | protein kinase C, epsilon | 0.0225357 |
| FLNA | filamin A, alpha | 0.021943 |
| RPL36A | ribosomal protein L36a | 0.0217624 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0216471 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0214226 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0213762 |
| APP | amyloid beta (A4) precursor protein | 0.0212791 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.021278 |
| RPS3 | ribosomal protein S3 | 0.0209832 |
| LDHA | lactate dehydrogenase A | 0.0208409 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0208359 |
| RPS23 | ribosomal protein S23 | 0.0207985 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0207603 |
| RPL27A | ribosomal protein L27a | 0.0203036 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0201593 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0199967 |
| R3HDM2 | R3H domain containing 2 | 0.0198468 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0195908 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0195072 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0193972 |
| ACLY | ATP citrate lyase | 0.0193593 |
| RPS14 | ribosomal protein S14 | 0.0193317 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | 0.019298 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0192095 |
| LMO7 | LIM domain 7 | 0.0189933 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0189448 |
| RPS7 | ribosomal protein S7 | 0.0189005 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.234084 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.214596 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.105502 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.102794 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0812102 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0807405 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0783534 |
| PCDH7 | protocadherin 7 | -0.0769262 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.072276 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0648802 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0639762 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0623556 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0619352 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0618336 |
| TENM3 | teneurin transmembrane protein 3 | -0.0558722 |
| EGR1 | early growth response 1 | -0.0551751 |
| PDGFC | platelet derived growth factor C | -0.0541609 |
| PFN1 | profilin 1 | -0.0517351 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0510681 |
| POTEF | POTE ankyrin domain family, member F | -0.0478521 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0462976 |
| DST | dystonin | -0.0454199 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0447805 |
| CCNL1 | cyclin L1 | -0.0425482 |
| TMSB10 | thymosin beta 10 | -0.0404542 |
| ECT2 | epithelial cell transforming 2 | -0.0402621 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0401587 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0401469 |
| CCN2 | cellular communication network factor 2 | -0.0393293 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0387293 |
| USP34 | ubiquitin specific peptidase 34 | -0.0384333 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0382374 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0377956 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0349726 |
| CCND1 | cyclin D1 | -0.0341746 |
| RANBP17 | RAN binding protein 17 | -0.0327943 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0311582 |
| PRR16 | proline rich 16 | -0.0307379 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0299155 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0298877 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0296944 |
| MAP1B | microtubule-associated protein 1B | -0.0291439 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0282511 |
| EDARADD | EDAR-associated death domain | -0.0279321 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0264926 |
| RTN4 | reticulon 4 | -0.0263865 |
| ZNF207 | zinc finger protein 207 | -0.0254898 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0249448 |
| SKIL | SKI-like proto-oncogene | -0.0248634 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0244314 |
| CENPF | centromere protein F, 350/400kDa | -0.024318 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0242152 |
| NRXN3 | neurexin 3 | -0.0241581 |
| GOLGA4 | golgin A4 | -0.0240951 |
| NF1 | neurofibromin 1 | -0.0239325 |
| HELLS | helicase, lymphoid-specific | -0.0238961 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0236788 |
| HDAC9 | histone deacetylase 9 | -0.0236535 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0236436 |
| VMP1 | vacuole membrane protein 1 | -0.0233434 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -0.0233251 |
| RPL37A | ribosomal protein L37a | -0.0233077 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0232678 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0231485 |
| QKI | QKI, KH domain containing, RNA binding | -0.0230377 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | -0.022983 |
| TUBA1B | tubulin, alpha 1b | -0.0228742 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0227875 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0227373 |
| NABP1 | nucleic acid binding protein 1 | -0.0225282 |
| NOP58 | NOP58 ribonucleoprotein | -0.0224832 |
| HMGA1 | high mobility group AT-hook 1 | -0.0220145 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.0215429 |
| PCM1 | pericentriolar material 1 | -0.0211261 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.020932 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0206091 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0204903 |
| TNPO1 | transportin 1 | -0.0204486 |
| THOC2 | THO complex 2 | -0.0204356 |
| HMGB1 | high mobility group box 1 | -0.0202862 |
| BRD2 | bromodomain containing 2 | -0.0200182 |
| CALD1 | caldesmon 1 | -0.0198609 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0198537 |
| NEGR1 | neuronal growth regulator 1 | -0.0198396 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.019806 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.0197519 |
| ZFR | zinc finger RNA binding protein | -0.0195813 |
| DTNA | dystrobrevin, alpha | -0.0195043 |
| WWC2 | WW and C2 domain containing 2 | -0.019369 |
| ERBIN | erbb2 interacting protein | -0.0193679 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0193174 |
| MATR3 | matrin 3 | -0.0192812 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0190147 |
| TEAD4 | TEA domain family member 4 | -0.0189706 |
| CEP290 | centrosomal protein 290kDa | -0.0186742 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0185792 |
| TGM2 | transglutaminase 2 | -0.018462 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0183783 |
| TBCA | tubulin folding cofactor A | -0.0183626 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0182064 |
