| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Crizotinib (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Crizotinib (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.212541 |
| VIM | vimentin | 0.196135 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.119127 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.107596 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0954356 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0891458 |
| APP | amyloid beta (A4) precursor protein | 0.0807524 |
| CANX | calnexin | 0.0803342 |
| FLNA | filamin A, alpha | 0.0791708 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0755817 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0753731 |
| CALR | calreticulin | 0.0735825 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0666119 |
| VCL | vinculin | 0.0662707 |
| RPS4X | ribosomal protein S4, X-linked | 0.0640607 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0624789 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0583136 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0537582 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0530694 |
| SEPTIN9 | septin 9 | 0.0524945 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0512504 |
| RPL7 | ribosomal protein L7 | 0.0499655 |
| PLEC | plectin | 0.0495359 |
| FMNL2 | formin-like 2 | 0.046716 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0460832 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0458299 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0456835 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0436144 |
| SMAD3 | SMAD family member 3 | 0.0430475 |
| RPL19 | ribosomal protein L19 | 0.0420938 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0414358 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0413614 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0410373 |
| PLK2 | polo-like kinase 2 | 0.0409419 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0405965 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0404324 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0402297 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0396576 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0395509 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0393628 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0389906 |
| APOL1 | apolipoprotein L, 1 | 0.036693 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0366469 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0354709 |
| COPA | coatomer protein complex, subunit alpha | 0.0351409 |
| G0S2 | G0/G1 switch 2 | 0.0350861 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0345341 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0343427 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0340139 |
| NAV2 | neuron navigator 2 | 0.0339931 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0337045 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0333008 |
| SUCO | SUN domain containing ossification factor | 0.0332937 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.032735 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.0320523 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0318615 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0317258 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0314449 |
| JAK1 | Janus kinase 1 | 0.031206 |
| MSH6 | mutS homolog 6 | 0.0306551 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0301163 |
| FTL | ferritin, light polypeptide | 0.0300867 |
| ACLY | ATP citrate lyase | 0.0297628 |
| ADM | adrenomedullin | 0.0296622 |
| CTBP2 | C-terminal binding protein 2 | 0.0293627 |
| HDGF | hepatoma-derived growth factor | 0.0292851 |
| HLA-E | major histocompatibility complex, class I, E | 0.0292467 |
| ATF4 | activating transcription factor 4 | 0.0287226 |
| MRTFA | myocardin related transcription factor A | 0.0285193 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0281808 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0280167 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0280133 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0268603 |
| SPTY2D1 | SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) | 0.0266433 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0266098 |
| GOLGA2 | golgin A2 | 0.0264326 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.026113 |
| LRRC59 | leucine rich repeat containing 59 | 0.0260942 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0260679 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0259567 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0257546 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.0257321 |
| RPL4 | ribosomal protein L4 | 0.0254235 |
| SQSTM1 | sequestosome 1 | 0.0252301 |
| RPL23 | ribosomal protein L23 | 0.0250556 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0249657 |
| YME1L1 | YME1-like 1 ATPase | 0.0248981 |
| HKDC1 | hexokinase domain containing 1 | 0.0248257 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0246328 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | 0.0245527 |
| RAD21 | RAD21 homolog (S. pombe) | 0.024524 |
| SET | SET nuclear proto-oncogene | 0.0243545 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0242841 |
| KRT18 | keratin 18, type I | 0.0242082 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.0241104 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0240037 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0239996 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0239172 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0236992 |
| INTS6 | integrator complex subunit 6 | 0.023469 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.245363 |
| GPC6 | glypican 6 | -0.143899 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0939779 |
| ASPH | aspartate beta-hydroxylase | -0.0858433 |
| GLIS3 | GLIS family zinc finger 3 | -0.0841982 |
| CD44 | CD44 molecule (Indian blood group) | -0.0744164 |
| RTN4 | reticulon 4 | -0.0690352 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0679013 |
| TXNRD1 | thioredoxin reductase 1 | -0.0600573 |
| POTEF | POTE ankyrin domain family, member F | -0.0564178 |
| PFN1 | profilin 1 | -0.0526945 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0520792 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0520318 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0514902 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.051456 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0451082 |
| MAP1B | microtubule-associated protein 1B | -0.0427304 |
| HMGB1 | high mobility group box 1 | -0.0426264 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0415083 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0395003 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0391044 |
| OSMR | oncostatin M receptor | -0.0390391 |
| EHBP1 | EH domain binding protein 1 | -0.0385238 |
| CBX3 | chromobox homolog 3 | -0.0383166 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0369945 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0366486 |
| ETV6 | ets variant 6 | -0.0364067 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0360237 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0351151 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0350252 |
| EFNA5 | ephrin-A5 | -0.0339542 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0335648 |
| NFIB | nuclear factor I/B | -0.0331583 |
| DIAPH3 | diaphanous-related formin 3 | -0.0331246 |
| MX1 | MX dynamin-like GTPase 1 | -0.0326927 |
| TUSC3 | tumor suppressor candidate 3 | -0.0304562 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0303133 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.029279 |
| TMSB10 | thymosin beta 10 | -0.0289967 |
| MYADM | myeloid-associated differentiation marker | -0.0288192 |
| NRP1 | neuropilin 1 | -0.0284184 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0280648 |
| SP3 | Sp3 transcription factor | -0.0279556 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0279289 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0275311 |
| PTGR1 | prostaglandin reductase 1 | -0.0273105 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | -0.0271599 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0269798 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0269242 |
| IFI44L | interferon-induced protein 44-like | -0.0268114 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -0.0268092 |
| ZNF207 | zinc finger protein 207 | -0.0266167 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0265448 |
| RRM2 | ribonucleotide reductase M2 | -0.0256965 |
| RPL28 | ribosomal protein L28 | -0.0254462 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0253468 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0250024 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0249884 |
| RAI14 | retinoic acid induced 14 | -0.0247716 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0247614 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0242976 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0237541 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0234168 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0233989 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0228784 |
| ATXN10 | ataxin 10 | -0.0227878 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0227686 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0227347 |
| CDCP1 | CUB domain containing protein 1 | -0.0226628 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0224465 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0222254 |
| ZFP36 | ZFP36 ring finger protein | -0.0216529 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0215495 |
| AZIN1 | antizyme inhibitor 1 | -0.0214455 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.0212084 |
| GNA12 | guanine nucleotide binding protein (G protein) alpha 12 | -0.0210183 |
| RUNX1 | runt-related transcription factor 1 | -0.020974 |
| DOCK5 | dedicator of cytokinesis 5 | -0.020897 |
| CCDC146 | coiled-coil domain containing 146 | -0.0208861 |
| FOSL1 | FOS-like antigen 1 | -0.0207881 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0206496 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0205984 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0205389 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0202207 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0199815 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0198281 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0198222 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0198192 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0197189 |
| FOXP1 | forkhead box P1 | -0.0196767 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0196194 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0193866 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0191479 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0191198 |
| CDK6 | cyclin-dependent kinase 6 | -0.0190381 |
| TRAM1 | translocation associated membrane protein 1 | -0.0190305 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | -0.0190005 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0189307 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0187813 |
| NDRG1 | N-myc downstream regulated 1 | -0.0187141 |
