| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Crizotinib (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Crizotinib (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.249376 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.162331 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.155045 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.127048 |
| SMAD3 | SMAD family member 3 | 0.109799 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0819933 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.078401 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0778252 |
| UBC | ubiquitin C | 0.074921 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.071171 |
| VIM | vimentin | 0.0664964 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0659703 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0643916 |
| AHNAK | AHNAK nucleoprotein | 0.0639561 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0628184 |
| LDHA | lactate dehydrogenase A | 0.0612721 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0591462 |
| FLNA | filamin A, alpha | 0.0586315 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0574472 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.057007 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0549064 |
| ANXA2 | annexin A2 | 0.054653 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0545655 |
| PLEC | plectin | 0.0540819 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0520751 |
| FLNB | filamin B, beta | 0.0510659 |
| PGK1 | phosphoglycerate kinase 1 | 0.0510284 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.049912 |
| MSN | moesin | 0.0488318 |
| CANX | calnexin | 0.0485931 |
| ACTN4 | actinin, alpha 4 | 0.0484263 |
| VCL | vinculin | 0.0482682 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0480244 |
| RPL4 | ribosomal protein L4 | 0.0476431 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0473109 |
| CLTC | clathrin, heavy chain (Hc) | 0.046018 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0454277 |
| CA12 | carbonic anhydrase XII | 0.045423 |
| CMIP | c-Maf inducing protein | 0.0452338 |
| MCL1 | myeloid cell leukemia 1 | 0.0445648 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.043452 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0429236 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0423079 |
| KRT18 | keratin 18, type I | 0.0401148 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0381127 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.038044 |
| TMSB4X | thymosin beta 4, X-linked | 0.0373068 |
| SEPTIN9 | septin 9 | 0.0370133 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0363344 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0357271 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0346576 |
| PCBP2 | poly(rC) binding protein 2 | 0.034481 |
| FMNL2 | formin-like 2 | 0.0342923 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0341106 |
| KRT7 | keratin 7, type II | 0.0339154 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0338253 |
| DSPP | dentin sialophosphoprotein | 0.0335076 |
| SPAG9 | sperm associated antigen 9 | 0.0330888 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0324715 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.032392 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0323604 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0319799 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0316285 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.031424 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0313549 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0310182 |
| STC1 | stanniocalcin 1 | 0.0305705 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.0304314 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0296247 |
| DENND5A | DENN/MADD domain containing 5A | 0.0296226 |
| MYOF | myoferlin | 0.0295536 |
| CALU | calumenin | 0.0294673 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.029285 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.029271 |
| YME1L1 | YME1-like 1 ATPase | 0.0288812 |
| CORO1C | coronin, actin binding protein, 1C | 0.0288244 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.028285 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0282129 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0280667 |
| APP | amyloid beta (A4) precursor protein | 0.0274026 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0272816 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0272354 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0270648 |
| MYO1E | myosin IE | 0.0262843 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0259113 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0255165 |
| ADAR | adenosine deaminase, RNA-specific | 0.0253699 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0252098 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0251314 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0246418 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0245928 |
| LOXL2 | lysyl oxidase-like 2 | 0.0243612 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0243027 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.024154 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0237989 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.023789 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0237089 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0234679 |
| ANO6 | anoctamin 6 | 0.0232139 |
| ACLY | ATP citrate lyase | 0.0232057 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.155284 |
| TMSB10 | thymosin beta 10 | -0.150773 |
| FTL | ferritin, light polypeptide | -0.116041 |
| RPS19 | ribosomal protein S19 | -0.113383 |
| RPLP1 | ribosomal protein, large, P1 | -0.0853617 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0771417 |
| RPS6 | ribosomal protein S6 | -0.0750395 |
| ACTG1 | actin gamma 1 | -0.0582739 |
| RPLP2 | ribosomal protein, large, P2 | -0.0532517 |
| RPL28 | ribosomal protein L28 | -0.0521124 |
| MT1X | metallothionein 1X | -0.0497013 |
| RPS16 | ribosomal protein S16 | -0.0486182 |
| POTEF | POTE ankyrin domain family, member F | -0.0478605 |
| RPL12 | ribosomal protein L12 | -0.0444763 |
| RPS8 | ribosomal protein S8 | -0.0437348 |
| PFN1 | profilin 1 | -0.0428198 |
| RPL19 | ribosomal protein L19 | -0.04054 |
| RPL34 | ribosomal protein L34 | -0.0384451 |
| LAMA5 | laminin, alpha 5 | -0.0379113 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0377186 |
| RPL26 | ribosomal protein L26 | -0.0372906 |
| RPL23 | ribosomal protein L23 | -0.0364995 |
| RPS25 | ribosomal protein S25 | -0.0356755 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0354207 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0345286 |
| KRT81 | keratin 81, type II | -0.0340221 |
| RPL35A | ribosomal protein L35a | -0.033722 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0327925 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0323707 |
| RPS24 | ribosomal protein S24 | -0.0321834 |
| RPS29 | ribosomal protein S29 | -0.0321211 |
| NDRG1 | N-myc downstream regulated 1 | -0.0315472 |
| PTMA | prothymosin, alpha | -0.0314113 |
| RPL31 | ribosomal protein L31 | -0.0289522 |
| EGR1 | early growth response 1 | -0.0285833 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.027203 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0267311 |
| RPL32 | ribosomal protein L32 | -0.026724 |
| RAD51B | RAD51 paralog B | -0.0264907 |
| TBCA | tubulin folding cofactor A | -0.0264884 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0260161 |
| RPL36 | ribosomal protein L36 | -0.0258793 |
| RPL9 | ribosomal protein L9 | -0.0258601 |
| RPL5 | ribosomal protein L5 | -0.0254997 |
| RPL37A | ribosomal protein L37a | -0.0253538 |
| RPS13 | ribosomal protein S13 | -0.0253181 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0247387 |
| RPL30 | ribosomal protein L30 | -0.0241396 |
| RPS12 | ribosomal protein S12 | -0.0238529 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0236382 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.023516 |
| HMGA1 | high mobility group AT-hook 1 | -0.0233817 |
| EGFR | epidermal growth factor receptor | -0.0232715 |
| PARD3 | par-3 family cell polarity regulator | -0.0228018 |
| RPL27 | ribosomal protein L27 | -0.0227501 |
| RPL7A | ribosomal protein L7a | -0.022404 |
| RPS20 | ribosomal protein S20 | -0.0215778 |
| AUTS2 | autism susceptibility candidate 2 | -0.021459 |
| RPS17 | ribosomal protein S17 | -0.0212643 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0211998 |
| PCM1 | pericentriolar material 1 | -0.0211557 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.020775 |
| RPS5 | ribosomal protein S5 | -0.0207414 |
| RPS27 | ribosomal protein S27 | -0.0205892 |
| RACK1 | receptor for activated C kinase 1 | -0.0205656 |
| RPS23 | ribosomal protein S23 | -0.0205085 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0204228 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0201447 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0199444 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0192544 |
| DENND1A | DENN/MADD domain containing 1A | -0.0188559 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.018836 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0182741 |
| HMGB1 | high mobility group box 1 | -0.0179938 |
| ANXA1 | annexin A1 | -0.0179136 |
| RPS11 | ribosomal protein S11 | -0.0178163 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0178055 |
| HIP1 | huntingtin interacting protein 1 | -0.0177755 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0177286 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -0.0177242 |
| COX6B1 | cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) | -0.0176991 |
| SHOC2 | soc-2 suppressor of clear homolog (C. elegans) | -0.0175832 |
| INTS6 | integrator complex subunit 6 | -0.0175509 |
| RPS15 | ribosomal protein S15 | -0.0175362 |
| TNPO3 | transportin 3 | -0.0173903 |
| BICC1 | BicC family RNA binding protein 1 | -0.0173446 |
| SEC61G | Sec61 gamma subunit | -0.0172991 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0172867 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0170194 |
| FA2H | fatty acid 2-hydroxylase | -0.0169623 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0168808 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0168701 |
| NRG1 | neuregulin 1 | -0.01675 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0166683 |
| MYADM | myeloid-associated differentiation marker | -0.0164925 |
| RPS3 | ribosomal protein S3 | -0.0163564 |
| URI1 | URI1, prefoldin-like chaperone | -0.0162412 |
| IER3 | immediate early response 3 | -0.0159411 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.015938 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0159375 |
