Crizotinib (hydrochloride)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Crizotinib (hydrochloride) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Crizotinib (hydrochloride)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.174758
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0970551
PEG10 paternally expressed 10 0.0849869
TMSB4X thymosin beta 4, X-linked 0.080761
MEST mesoderm specific transcript 0.0763109
VEGFA vascular endothelial growth factor A 0.0685082
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0658081
RPS4X ribosomal protein S4, X-linked 0.0585088
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0533325
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0521784
PTMA prothymosin, alpha 0.0515277
MGP matrix Gla protein 0.0447053
RPS23 ribosomal protein S23 0.0435137
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0394106
IGF2R insulin-like growth factor 2 receptor 0.0383745
CENPF centromere protein F, 350/400kDa 0.0382457
TBL1X transducin (beta)-like 1X-linked 0.0381662
RPL11 ribosomal protein L11 0.0374465
FLNA filamin A, alpha 0.0328965
KIF1A kinesin family member 1A 0.0316702
CKAP5 cytoskeleton associated protein 5 0.0316457
MKI67 marker of proliferation Ki-67 0.0314171
NCOR2 nuclear receptor corepressor 2 0.0312457
HSPA8 heat shock 70kDa protein 8 0.0310922
TLN1 talin 1 0.0309989
TRERF1 transcriptional regulating factor 1 0.0308313
RPL7 ribosomal protein L7 0.030805
TUBB tubulin, beta class I 0.030224
GPBP1 GC-rich promoter binding protein 1 0.0300141
MXI1 MAX interactor 1, dimerization protein 0.029257
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0288839
MYH9 myosin, heavy chain 9, non-muscle 0.0282924
SFTPA2 surfactant protein A2 0.0280551
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0278572
APLP2 amyloid beta (A4) precursor-like protein 2 0.0276677
RSL1D1 ribosomal L1 domain containing 1 0.027543
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0273122
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0271862
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0271769
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0271556
TAC4 tachykinin 4 (hemokinin) 0.0265382
CDC20 cell division cycle 20 0.0259598
HMGB2 high mobility group box 2 0.0259287
H1-2 H1.2 linker histone, cluster member 0.0257085
TBC1D15 TBC1 domain family, member 15 0.025708
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0249681
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0249389
RPL23 ribosomal protein L23 0.0246962
SPAG5 sperm associated antigen 5 0.0245983
NUMA1 nuclear mitotic apparatus protein 1 0.0244782
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0239672
EIF4B eukaryotic translation initiation factor 4B 0.023878
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0237443
UVRAG UV radiation resistance associated 0.0235404
TPI1 triosephosphate isomerase 1 0.0234383
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0234349
KTN1 kinectin 1 (kinesin receptor) 0.0233005
SNX3 sorting nexin 3 0.0232553
ZNF608 zinc finger protein 608 0.023248
NRDC nardilysin convertase 0.0230133
TNRC6A trinucleotide repeat containing 6A 0.022944
MARCHF6 membrane associated ring-CH-type finger 6 0.0227968
CEP250 centrosomal protein 250kDa 0.0227798
BIRC5 baculoviral IAP repeat containing 5 0.0226775
ENO1 enolase 1, (alpha) 0.0226158
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.0225332
SET SET nuclear proto-oncogene 0.0223627
LONP2 lon peptidase 2, peroxisomal 0.0222094
PAXBP1 PAX3 and PAX7 binding protein 1 0.0221817
BRD4 bromodomain containing 4 0.0221472
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0221077
GSK3B glycogen synthase kinase 3 beta 0.0218176
SQSTM1 sequestosome 1 0.0217934
BCOR BCL6 corepressor 0.0217292
TM9SF3 transmembrane 9 superfamily member 3 0.0216671
NUSAP1 nucleolar and spindle associated protein 1 0.0216563
HP1BP3 heterochromatin protein 1, binding protein 3 0.021543
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0215355
MEMO1 mediator of cell motility 1 0.0214074
SERINC1 serine incorporator 1 0.0213902
ADIPOR2 adiponectin receptor 2 0.0213807
MYOF myoferlin 0.0211728
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0211389
SH3PXD2A SH3 and PX domains 2A 0.021085
RPS12 ribosomal protein S12 0.0208772
PAPOLA poly(A) polymerase alpha 0.0207457
MYEF2 myelin expression factor 2 0.0207114
GAN gigaxonin 0.0206212
RAD21 RAD21 homolog (S. pombe) 0.0204748
CENPE centromere protein E, 312kDa 0.0204682
RPL31 ribosomal protein L31 0.0204651
SRP54 signal recognition particle 54kDa 0.0202621
EIF3I eukaryotic translation initiation factor 3, subunit I 0.0200319
ADD1 adducin 1 (alpha) 0.0199521
KDM6A lysine (K)-specific demethylase 6A 0.0198548
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0197066
PLEKHA7 pleckstrin homology domain containing, family A member 7 0.0196969
SERBP1 SERPINE1 mRNA binding protein 1 0.0196345
GDI2 GDP dissociation inhibitor 2 0.0194804
KIAA1191 KIAA1191 0.01925

decreased expression

Symbol Name Standardized Value
PRKG1 protein kinase, cGMP-dependent, type I -0.209387
CADM2 cell adhesion molecule 2 -0.146314
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.133445
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0818184
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0806505
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0769819
NFIB nuclear factor I/B -0.0721851
BCAS3 breast carcinoma amplified sequence 3 -0.0718554
ZNF292 zinc finger protein 292 -0.0671701
TRIO trio Rho guanine nucleotide exchange factor -0.0613426
RANBP17 RAN binding protein 17 -0.0584484
FNDC3B fibronectin type III domain containing 3B -0.0526466
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0520508
TMSB10 thymosin beta 10 -0.0510992
TPK1 thiamin pyrophosphokinase 1 -0.0501015
GPC6 glypican 6 -0.0480861
NDRG1 N-myc downstream regulated 1 -0.0473686
DLG1 discs, large homolog 1 (Drosophila) -0.0473163
GMDS GDP-mannose 4,6-dehydratase -0.0465195
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0432209
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0425765
WWOX WW domain containing oxidoreductase -0.0418918
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0408943
RAB1A RAB1A, member RAS oncogene family -0.0399447
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.039322
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0392555
PDE4D phosphodiesterase 4D, cAMP-specific -0.0392076
FN1 fibronectin 1 -0.0389777
TSHZ2 teashirt zinc finger homeobox 2 -0.0386065
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0381723
TXNRD1 thioredoxin reductase 1 -0.0377448
PDE8A phosphodiesterase 8A -0.037448
MSRB3 methionine sulfoxide reductase B3 -0.037379
CUX1 cut-like homeobox 1 -0.0368983
PCM1 pericentriolar material 1 -0.0368882
SCAF11 SR-related CTD-associated factor 11 -0.0366207
FBXO11 F-box protein 11 -0.0363967
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.035903
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0353986
GPHN gephyrin -0.0344363
SEPTIN11 septin 11 -0.034055
EGR1 early growth response 1 -0.0339747
TBK1 TANK-binding kinase 1 -0.0338785
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0336083
MAGED1 melanoma antigen family D1 -0.0333343
EIF5B eukaryotic translation initiation factor 5B -0.0331038
RSRC1 arginine/serine-rich coiled-coil 1 -0.0325261
TRA2A transformer 2 alpha homolog (Drosophila) -0.032114
OLA1 Obg-like ATPase 1 -0.0319491
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A -0.0317714
B2M beta-2-microglobulin -0.031461
SRSF4 serine/arginine-rich splicing factor 4 -0.0313915
MEOX2 mesenchyme homeobox 2 -0.0312533
PHF14 PHD finger protein 14 -0.0311767
KDM4C lysine (K)-specific demethylase 4C -0.0310371
ERBIN erbb2 interacting protein -0.0310301
DOCK7 dedicator of cytokinesis 7 -0.0308187
ZNF638 zinc finger protein 638 -0.0307695
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0307254
PIBF1 progesterone immunomodulatory binding factor 1 -0.0306589
MATR3 matrin 3 -0.0306479
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0303719
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0303023
PARD3 par-3 family cell polarity regulator -0.0300235
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0299796
FBXL7 F-box and leucine-rich repeat protein 7 -0.0296978
RNF24 ring finger protein 24 -0.0295755
POM121C POM121 transmembrane nucleoporin C -0.0292037
PALLD palladin, cytoskeletal associated protein -0.0290779
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0289175
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0287698
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.0287524
KANK1 KN motif and ankyrin repeat domains 1 -0.0285994
HMGA1 high mobility group AT-hook 1 -0.0284626
TOP1 topoisomerase (DNA) I -0.0281964
RTN4 reticulon 4 -0.0278065
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0276368
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0276216
NBEA neurobeachin -0.0275485
CLINT1 clathrin interactor 1 -0.0274621
TRIP12 thyroid hormone receptor interactor 12 -0.0273752
PDE10A phosphodiesterase 10A -0.0273134
FAF1 Fas (TNFRSF6) associated factor 1 -0.0270154
ZNF736 zinc finger protein 736 -0.0267091
TCERG1 transcription elongation regulator 1 -0.0266547
P4HB prolyl 4-hydroxylase, beta polypeptide -0.026579
SOD2 superoxide dismutase 2, mitochondrial -0.0264156
EGFR epidermal growth factor receptor -0.0262098
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0261831
SKIL SKI-like proto-oncogene -0.0261362
PDGFC platelet derived growth factor C -0.0260128
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.025978
ZBTB20 zinc finger and BTB domain containing 20 -0.0259721
BBX bobby sox homolog (Drosophila) -0.0259181
VMP1 vacuole membrane protein 1 -0.0258595
RAD51B RAD51 paralog B -0.0257003
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0256901
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.0254973
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0253037
ELL2 elongation factor, RNA polymerase II, 2 -0.0252958