Crizotinib (hydrochloride)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Crizotinib (hydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Crizotinib (hydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.28873
MUC17 mucin 17, cell surface associated 0.206744
VIM vimentin 0.113585
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.100404
PLEC plectin 0.0944785
MYH9 myosin, heavy chain 9, non-muscle 0.0832168
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0724537
KRT18 keratin 18, type I 0.0715293
ITPRID2 ITPR interacting domain containing 2 0.070942
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0681236
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0651393
PTMA prothymosin, alpha 0.062108
SMAD3 SMAD family member 3 0.0544258
VCL vinculin 0.0531762
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0501321
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0466404
FLNB filamin B, beta 0.0459799
PSD3 pleckstrin and Sec7 domain containing 3 0.0420808
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0410435
EZR ezrin 0.0386928
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0385896
DSPP dentin sialophosphoprotein 0.0384605
TUFT1 tuftelin 1 0.0365654
SQSTM1 sequestosome 1 0.036496
CANX calnexin 0.0364091
KDM3A lysine (K)-specific demethylase 3A 0.0352095
ANXA11 annexin A11 0.0351583
ARGLU1 arginine and glutamate rich 1 0.0349416
SERINC1 serine incorporator 1 0.0345106
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.034307
TRA2A transformer 2 alpha homolog (Drosophila) 0.0333284
RPL7 ribosomal protein L7 0.0324981
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0320445
RSL1D1 ribosomal L1 domain containing 1 0.0317166
HSPA8 heat shock 70kDa protein 8 0.0308468
DSCAM Down syndrome cell adhesion molecule 0.0298405
NCOR2 nuclear receptor corepressor 2 0.0297963
ACTN4 actinin, alpha 4 0.0294735
RAD21 RAD21 homolog (S. pombe) 0.0289578
EEF2 eukaryotic translation elongation factor 2 0.028698
BHLHE40 basic helix-loop-helix family, member e40 0.0286811
RPS4X ribosomal protein S4, X-linked 0.0284775
CAB39 calcium binding protein 39 0.0283845
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0283294
ERRFI1 ERBB receptor feedback inhibitor 1 0.027819
PGK1 phosphoglycerate kinase 1 0.0271557
LMTK2 lemur tyrosine kinase 2 0.026807
TMSB4X thymosin beta 4, X-linked 0.0256106
PNN pinin, desmosome associated protein 0.0255686
APP amyloid beta (A4) precursor protein 0.0255385
RPL13A ribosomal protein L13a 0.0249552
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0245564
CORO1C coronin, actin binding protein, 1C 0.0244905
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0241384
RSRC2 arginine/serine-rich coiled-coil 2 0.0235791
RPL4 ribosomal protein L4 0.023553
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.023552
LYZ lysozyme 0.0234952
ARHGAP42 Rho GTPase activating protein 42 0.0229868
PALM2AKAP2 PALM2 and AKAP2 fusion 0.022669
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0223535
MYOF myoferlin 0.0218709
RPS3 ribosomal protein S3 0.0217989
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0216869
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.021437
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.0211789
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0210653
TOP1 topoisomerase (DNA) I 0.0209868
TNIP1 TNFAIP3 interacting protein 1 0.0209694
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0206014
SLTM SAFB-like, transcription modulator 0.0205749
FLNA filamin A, alpha 0.0205556
PTK2 protein tyrosine kinase 2 0.0204149
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0201964
KRT8 keratin 8, type II 0.0200571
FNDC3B fibronectin type III domain containing 3B 0.0195919
PTPRF protein tyrosine phosphatase, receptor type, F 0.0195539
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0190101
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0188899
NUMA1 nuclear mitotic apparatus protein 1 0.0183386
DST dystonin 0.0183077
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0182135
EPCAM epithelial cell adhesion molecule 0.0181634
OSBP2 oxysterol binding protein 2 0.0180742
MYO6 myosin VI 0.0180279
EIF4B eukaryotic translation initiation factor 4B 0.0179516
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0179204
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0178262
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.0176087
CUL3 cullin 3 0.0175579
OGA O-GlcNAcase 0.0174876
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0173547
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0173013
FAT1 FAT atypical cadherin 1 0.0172959
CTNND1 catenin (cadherin-associated protein), delta 1 0.017213
MATR3 matrin 3 0.0171659
EMP1 epithelial membrane protein 1 0.017069
AHNAK2 AHNAK nucleoprotein 2 0.0170619
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0170257
RPS7 ribosomal protein S7 0.0169492

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.191475
NDRG1 N-myc downstream regulated 1 -0.175355
POTEF POTE ankyrin domain family, member F -0.174728
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.121225
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0924779
SACK1A scaffolding CK1 anchoring protein A -0.0895383
TMSB10 thymosin beta 10 -0.0892739
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0758548
S100A10 S100 calcium binding protein A10 -0.0746275
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0718245
MXD1 MAX dimerization protein 1 -0.0717513
EGR1 early growth response 1 -0.0688466
HMGA1 high mobility group AT-hook 1 -0.0647885
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0642016
TXNIP thioredoxin interacting protein -0.0627595
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0626743
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0612724
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0567395
F3 coagulation factor III (thromboplastin, tissue factor) -0.0546683
KLK10 kallikrein-related peptidase 10 -0.0502242
IGFBP3 insulin-like growth factor binding protein 3 -0.0500042
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0488407
SKAP2 src kinase associated phosphoprotein 2 -0.0480645
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0444591
CLMP CXADR-like membrane protein -0.0442483
TRRAP transformation/transcription domain-associated protein -0.0432713
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0429329
GREB1L growth regulation by estrogen in breast cancer-like -0.041662
ANXA2 annexin A2 -0.0414222
DIAPH2 diaphanous-related formin 2 -0.0412684
TXNRD1 thioredoxin reductase 1 -0.0408481
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0399192
S100A11 S100 calcium binding protein A11 -0.0391006
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0387837
UBE2H ubiquitin-conjugating enzyme E2H -0.0385981
DOCK5 dedicator of cytokinesis 5 -0.0380262
FAM3C family with sequence similarity 3, member C -0.0374488
LAMA4 laminin, alpha 4 -0.0364191
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0362039
RPL35A ribosomal protein L35a -0.0360877
LOC112694756 uncharaterized LOC112694756 -0.0355805
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0355143
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0352384
BLZF1 basic leucine zipper nuclear factor 1 -0.0350219
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0347929
NPSR1 neuropeptide S receptor 1 -0.0347559
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0344554
LY6E lymphocyte antigen 6 complex, locus E -0.0343646
DSG2 desmoglein 2 -0.0339858
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0338861
BAIAP2L1 BAI1-associated protein 2-like 1 -0.032665
ARF4 ADP-ribosylation factor 4 -0.0324065
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0321975
FTL ferritin, light polypeptide -0.0321734
GOLGA4 golgin A4 -0.0318001
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0316667
PARD3 par-3 family cell polarity regulator -0.0313243
EGFR epidermal growth factor receptor -0.030891
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0307816
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0307529
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.030493
SLC35F3 solute carrier family 35, member F3 -0.0302895
AKAP9 A kinase (PRKA) anchor protein 9 -0.0300957
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0298181
HMGA2 high mobility group AT-hook 2 -0.0293958
SEC31A SEC31 homolog A (S. cerevisiae) -0.0289378
LAMB3 laminin, beta 3 -0.0286557
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0286431
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0282183
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0279674
EXT1 exostosin glycosyltransferase 1 -0.0278546
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0278034
CCDC88A coiled-coil domain containing 88A -0.0277561
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0273913
SEC24A SEC24 family member A -0.0272266
MAML2 mastermind-like 2 (Drosophila) -0.026541
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0261375
PFN1 profilin 1 -0.0259278
CALU calumenin -0.0258285
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0258063
CSTB cystatin B (stefin B) -0.025803
RIOK3 RIO kinase 3 -0.0256517
RAB7A RAB7A, member RAS oncogene family -0.0255735
S100A6 S100 calcium binding protein A6 -0.0254054
VDAC1 voltage-dependent anion channel 1 -0.0252215
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0249145
RPL34 ribosomal protein L34 -0.0247713
ESYT2 extended synaptotagmin-like protein 2 -0.0246571
RPS21 ribosomal protein S21 -0.024446
RPL8 ribosomal protein L8 -0.0244367
FBXO11 F-box protein 11 -0.0243148
FTH1 ferritin, heavy polypeptide 1 -0.024044
CD59 CD59 molecule, complement regulatory protein -0.024
GCC2 GRIP and coiled-coil domain containing 2 -0.0237735
PRSS3 protease, serine, 3 -0.0235156
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0234283
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0233551
RUNX1 runt-related transcription factor 1 -0.023212
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0231538
PDE4D phosphodiesterase 4D, cAMP-specific -0.0231052