| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Crizotinib (hydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Crizotinib (hydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0659637 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0651811 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0588332 |
| CEP250 | centrosomal protein 250kDa | 0.0576117 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.0574823 |
| RPL19 | ribosomal protein L19 | 0.0501692 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0478667 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0417311 |
| FADS2 | fatty acid desaturase 2 | 0.0394166 |
| NDRG1 | N-myc downstream regulated 1 | 0.039303 |
| RPL23 | ribosomal protein L23 | 0.0390366 |
| KRT18 | keratin 18, type I | 0.0387701 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.0375042 |
| VEGFA | vascular endothelial growth factor A | 0.0373117 |
| FDPS | farnesyl diphosphate synthase | 0.032913 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0320573 |
| VCL | vinculin | 0.0318118 |
| RAD51B | RAD51 paralog B | 0.030748 |
| SQLE | squalene epoxidase | 0.0300029 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0289793 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0289085 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0288036 |
| TOB1 | transducer of ERBB2, 1 | 0.0277626 |
| YAP1 | Yes-associated protein 1 | 0.0273968 |
| FAM168A | family with sequence similarity 168, member A | 0.0271638 |
| DSTN | destrin (actin depolymerizing factor) | 0.0269892 |
| FLNA | filamin A, alpha | 0.0260886 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0257042 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0249886 |
| CLTC | clathrin, heavy chain (Hc) | 0.0237651 |
| FOXO3 | forkhead box O3 | 0.0237197 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0232854 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0228372 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0223358 |
| FASN | fatty acid synthase | 0.0220229 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0218894 |
| USO1 | USO1 vesicle transport factor | 0.0218668 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0214173 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0212085 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.020802 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0207415 |
| PNN | pinin, desmosome associated protein | 0.0205715 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0204968 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.0202782 |
| SCARB1 | scavenger receptor class B, member 1 | 0.0202348 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.019897 |
| CCNG2 | cyclin G2 | 0.0198655 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0197335 |
| KRT86 | keratin 86, type II | 0.0192238 |
| MCL1 | myeloid cell leukemia 1 | 0.0191353 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0189758 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0189566 |
| ZNF652 | zinc finger protein 652 | 0.0187355 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0186608 |
| RPL7 | ribosomal protein L7 | 0.0185166 |
| DSPP | dentin sialophosphoprotein | 0.018365 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.018297 |
| SETD5 | SET domain containing 5 | 0.0179016 |
| FOXN3 | forkhead box N3 | 0.0178126 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0177246 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0177167 |
| ENAH | enabled homolog (Drosophila) | 0.0175481 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0175115 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0174872 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0174477 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0174363 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0173938 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0173157 |
| KIF16B | kinesin family member 16B | 0.017083 |
| ENO1 | enolase 1, (alpha) | 0.0169628 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0168731 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.016803 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0167795 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0167109 |
| ACLY | ATP citrate lyase | 0.0166334 |
| TMEM123 | transmembrane protein 123 | 0.0165998 |
| UQCC1 | ubiquinol-cytochrome c reductase complex assembly factor 1 | 0.0165409 |
| MYO10 | myosin X | 0.0163117 |
| LDHA | lactate dehydrogenase A | 0.0161696 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0159393 |
| RPS3 | ribosomal protein S3 | 0.0159297 |
| SET | SET nuclear proto-oncogene | 0.0158946 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0155848 |
| ASPH | aspartate beta-hydroxylase | 0.0155315 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0154517 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0152425 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0152424 |
| FBXO32 | F-box protein 32 | 0.015235 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0148147 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0148065 |
| PRELID2 | PRELI domain containing 2 | 0.0146512 |
| RC3H1 | ring finger and CCCH-type domains 1 | 0.0146012 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.014531 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0144009 |
| TPD52 | tumor protein D52 | 0.014372 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0143186 |
| RNASE12 | ribonuclease, RNase A family, 12 (non-active) | 0.0142279 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0141609 |
| RPL4 | ribosomal protein L4 | 0.0141604 |
| INTS6 | integrator complex subunit 6 | 0.014081 |
| Symbol | Name | Standardized Value |
|---|---|---|
| THSD4 | thrombospondin, type I, domain containing 4 | -0.10408 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -0.102506 |
| SMYD3 | SET and MYND domain containing 3 | -0.072152 |
| CCND1 | cyclin D1 | -0.0640833 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0620068 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0547644 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.0516125 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0500742 |
| OSMR | oncostatin M receptor | -0.0498109 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0495826 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.0491687 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0478851 |
| NTN4 | netrin 4 | -0.0468756 |
| S100A8 | S100 calcium binding protein A8 | -0.0449944 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.044147 |
| S100A9 | S100 calcium binding protein A9 | -0.0424556 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0412481 |
| CDK12 | cyclin-dependent kinase 12 | -0.0411902 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0409817 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0407783 |
| MYOF | myoferlin | -0.0398062 |
| MT2A | metallothionein 2A | -0.0387904 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0386402 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0373881 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0372428 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0367952 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0361617 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0356913 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0356293 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0346665 |
| ANXA2 | annexin A2 | -0.0338762 |
| NF1 | neurofibromin 1 | -0.0336999 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0331388 |
| INSR | insulin receptor | -0.0330181 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0324872 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0310497 |
| AHNAK | AHNAK nucleoprotein | -0.0307852 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0306494 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0300288 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0295287 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0293314 |
| TMSB10 | thymosin beta 10 | -0.0292667 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | -0.0289997 |
| MYO1D | myosin ID | -0.0286088 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0286003 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0284455 |
| HLA-B | major histocompatibility complex, class I, B | -0.0281462 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0278501 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0274377 |
| KLF6 | Kruppel-like factor 6 | -0.0267811 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0265057 |
| SDC4 | syndecan 4 | -0.026502 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0263749 |
| DUSP16 | dual specificity phosphatase 16 | -0.0257254 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0255828 |
| KAZN | kazrin, periplakin interacting protein | -0.0253809 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0252376 |
| HLA-C | major histocompatibility complex, class I, C | -0.0251816 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0249975 |
| TC2N | tandem C2 domains, nuclear | -0.0248565 |
| SYTL2 | synaptotagmin-like 2 | -0.0245643 |
| TOM1L1 | target of myb1 (chicken)-like 1 | -0.0244093 |
| YPEL2 | yippee-like 2 (Drosophila) | -0.0243196 |
| FGB | fibrinogen beta chain | -0.0237775 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.0236963 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0234463 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0226987 |
| TXNRD1 | thioredoxin reductase 1 | -0.022678 |
| RHOB | ras homolog family member B | -0.0223679 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0221659 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0217423 |
| B2M | beta-2-microglobulin | -0.021662 |
| BCAS1 | breast carcinoma amplified sequence 1 | -0.0213968 |
| MYO9A | myosin IXA | -0.0213293 |
| VMP1 | vacuole membrane protein 1 | -0.0213033 |
| NCOA6 | nuclear receptor coactivator 6 | -0.0212919 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0212746 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0211105 |
| JUN | jun proto-oncogene | -0.0208621 |
| S100P | S100 calcium binding protein P | -0.0206413 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | -0.0205775 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0205712 |
| SGMS1 | sphingomyelin synthase 1 | -0.0205249 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0205077 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0204527 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0202796 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0201467 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | -0.0201444 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0201111 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0200587 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.020027 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0200014 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0199844 |
| EGR1 | early growth response 1 | -0.0197168 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0195975 |
| MED13L | mediator complex subunit 13-like | -0.0194412 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.019386 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0193702 |
| PTK2 | protein tyrosine kinase 2 | -0.0193646 |
| SP100 | SP100 nuclear antigen | -0.0192058 |
