Crizotinib (hydrochloride)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Crizotinib (hydrochloride) perturbation in COLO 205 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Crizotinib (hydrochloride)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
STAT1 signal transducer and activator of transcription 1, 91kDa 0.100794
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.084838
STS steroid sulfatase (microsomal), isozyme S 0.081804
MYH9 myosin, heavy chain 9, non-muscle 0.0621965
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0617363
ARGLU1 arginine and glutamate rich 1 0.0578193
FNDC3B fibronectin type III domain containing 3B 0.056137
SMAD3 SMAD family member 3 0.0499264
PRKCA protein kinase C, alpha 0.0454861
INTS6 integrator complex subunit 6 0.0453617
RNF213 ring finger protein 213 0.0424383
NPSR1 neuropeptide S receptor 1 0.0423858
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0420744
VCL vinculin 0.0417702
PRELID2 PRELI domain containing 2 0.0416456
ARHGAP26 Rho GTPase activating protein 26 0.0411527
APLP2 amyloid beta (A4) precursor-like protein 2 0.0407684
SP100 SP100 nuclear antigen 0.039633
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.038843
PGK1 phosphoglycerate kinase 1 0.0387243
APOL1 apolipoprotein L, 1 0.0385627
SHB Src homology 2 domain containing adaptor protein B 0.0380977
EFNB2 ephrin-B2 0.0376019
PTBP3 polypyrimidine tract binding protein 3 0.0374276
RAD51B RAD51 paralog B 0.0359809
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0356127
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0349886
MLPH melanophilin 0.0340597
SERINC5 serine incorporator 5 0.0339583
DSPP dentin sialophosphoprotein 0.0334428
IFNGR1 interferon gamma receptor 1 0.032497
PLSCR2 phospholipid scramblase 2 0.0323786
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0322253
ERRFI1 ERBB receptor feedback inhibitor 1 0.0315303
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0313702
EXT1 exostosin glycosyltransferase 1 0.0312514
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0308059
LIMA1 LIM domain and actin binding 1 0.0307145
PTGR1 prostaglandin reductase 1 0.0305879
ERBIN erbb2 interacting protein 0.0305582
MACC1 metastasis associated in colon cancer 1 0.0293774
STK24 serine/threonine kinase 24 0.029208
ATP10B ATPase, class V, type 10B 0.0290661
STYXL2 serine/threonine/tyrosine interacting like 2 0.0289336
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0286724
ASPH aspartate beta-hydroxylase 0.0284119
FAT1 FAT atypical cadherin 1 0.0283414
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0283125
ADAR adenosine deaminase, RNA-specific 0.0279651
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0278359
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0272747
ZMYND8 zinc finger, MYND-type containing 8 0.0272572
SORBS1 sorbin and SH3 domain containing 1 0.0272301
PARP14 poly (ADP-ribose) polymerase family, member 14 0.027179
MYH14 myosin, heavy chain 14, non-muscle 0.0268915
EPSTI1 epithelial stromal interaction 1 (breast) 0.026622
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0258459
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0249439
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0246875
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0245766
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0243872
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0243544
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0243497
KLF5 Kruppel-like factor 5 (intestinal) 0.0242597
ANKRD17 ankyrin repeat domain 17 0.0241798
MYO10 myosin X 0.0237942
NRIP1 nuclear receptor interacting protein 1 0.0236783
PADI1 peptidyl arginine deiminase, type I 0.0233269
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.0231177
LAMB3 laminin, beta 3 0.0229375
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0229215
DSCAML1 Down syndrome cell adhesion molecule like 1 0.022696
NKD1 naked cuticle homolog 1 (Drosophila) 0.0226425
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0225679
HSH2D hematopoietic SH2 domain containing 0.0225438
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0224533
PDIA4 protein disulfide isomerase family A, member 4 0.0223192
SAMD9 sterile alpha motif domain containing 9 0.0221075
MAML2 mastermind-like 2 (Drosophila) 0.0221008
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0220794
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.021904
RIGI RNA sensor RIG-I 0.0216485
SAMD12 sterile alpha motif domain containing 12 0.0210196
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0209619
IGF1R insulin-like growth factor 1 receptor 0.0209329
ADAM10 ADAM metallopeptidase domain 10 0.0208062
PRKG1 protein kinase, cGMP-dependent, type I 0.0203202
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0203133
FKBP9 FK506 binding protein 9, 63 kDa 0.0203049
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0201689
PARP9 poly (ADP-ribose) polymerase family, member 9 0.0201489
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0197637
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0197377
FMN1 formin 1 0.0197361
MACF1 microtubule-actin crosslinking factor 1 0.0191684
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.0191063
KIF16B kinesin family member 16B 0.0190932
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0190845
DSCAM Down syndrome cell adhesion molecule 0.0189942
CTNND1 catenin (cadherin-associated protein), delta 1 0.0188077

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.129011
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.119929
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0812591
RPS6 ribosomal protein S6 -0.0680277
EGR1 early growth response 1 -0.0667061
RPL35A ribosomal protein L35a -0.0569178
HLA-B major histocompatibility complex, class I, B -0.0566451
RPLP1 ribosomal protein, large, P1 -0.0559677
B2M beta-2-microglobulin -0.053847
EZR ezrin -0.0528916
RPL34 ribosomal protein L34 -0.0502105
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0491233
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0490894
EIF1 eukaryotic translation initiation factor 1 -0.0467942
FTL ferritin, light polypeptide -0.0465526
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0456554
AHI1 Abelson helper integration site 1 -0.0447195
MBNL2 muscleblind-like splicing regulator 2 -0.0445693
GCLC glutamate-cysteine ligase, catalytic subunit -0.0438989
RPL19 ribosomal protein L19 -0.0414174
RPS8 ribosomal protein S8 -0.0406344
IRF1 interferon regulatory factor 1 -0.0402219
LCN2 lipocalin 2 -0.0386095
RPS19 ribosomal protein S19 -0.0385685
PDIA3 protein disulfide isomerase family A, member 3 -0.0380898
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0363948
TMSB10 thymosin beta 10 -0.0357384
ANXA2 annexin A2 -0.0354104
RHOBTB3 Rho-related BTB domain containing 3 -0.0352943
PERP PERP, TP53 apoptosis effector -0.0341092
POTEF POTE ankyrin domain family, member F -0.0337525
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0337371
RPL23 ribosomal protein L23 -0.0336642
HMGB1 high mobility group box 1 -0.0334777
ANKHD1 ankyrin repeat and KH domain containing 1 -0.033342
RPL12 ribosomal protein L12 -0.0332025
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0331939
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0331688
S100A10 S100 calcium binding protein A10 -0.0326973
GOLGA4 golgin A4 -0.032314
ITPKC inositol-trisphosphate 3-kinase C -0.0322635
ACTG1 actin gamma 1 -0.0307246
RPL37 ribosomal protein L37 -0.0303572
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.029897
LOC102724023 ES1 protein homolog, mitochondrial -0.0296593
HLA-C major histocompatibility complex, class I, C -0.029628
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0293082
PRRC2C proline-rich coiled-coil 2C -0.0292042
RPL31 ribosomal protein L31 -0.0289516
ZNF207 zinc finger protein 207 -0.028749
RPL38 ribosomal protein L38 -0.0283484
NF1 neurofibromin 1 -0.0281363
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0274743
TXNRD1 thioredoxin reductase 1 -0.0272456
UFM1 ubiquitin-fold modifier 1 -0.0271266
MORF4L2 mortality factor 4 like 2 -0.0270839
UGDH UDP-glucose 6-dehydrogenase -0.0267602
RPL26 ribosomal protein L26 -0.0266644
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0266444
PIBF1 progesterone immunomodulatory binding factor 1 -0.0266368
RPS27 ribosomal protein S27 -0.0262778
YBX3 Y box binding protein 3 -0.0261995
TMC5 transmembrane channel-like 5 -0.0255336
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0254605
TTC3 tetratricopeptide repeat domain 3 -0.0253952
RPS24 ribosomal protein S24 -0.0253486
TSC22D1 TSC22 domain family, member 1 -0.0252354
GOLPH3L golgi phosphoprotein 3-like -0.0243416
S100A6 S100 calcium binding protein A6 -0.0242471
WDR45B WD repeat domain 45B -0.0240644
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0238697
VDAC1 voltage-dependent anion channel 1 -0.0237654
RPL36A ribosomal protein L36a -0.0236501
RPS29 ribosomal protein S29 -0.0235877
TPR translocated promoter region, nuclear basket protein -0.02316
RPS25 ribosomal protein S25 -0.023076
ANXA1 annexin A1 -0.022961
SPDYA speedy/RINGO cell cycle regulator family member A -0.0228083
SAMD4A sterile alpha motif domain containing 4A -0.0225921
LMAN1 lectin, mannose-binding, 1 -0.02196
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0218751
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0214628
FTH1 ferritin, heavy polypeptide 1 -0.0213825
PTMA prothymosin, alpha -0.0213553
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0212984
RPS16 ribosomal protein S16 -0.0211243
NAMPT nicotinamide phosphoribosyltransferase -0.0209433
SLC38A1 solute carrier family 38, member 1 -0.020856
RPL32 ribosomal protein L32 -0.0206338
RPLP0 ribosomal protein, large, P0 -0.0205406
HDLBP high density lipoprotein binding protein -0.0204753
UBL3 ubiquitin-like 3 -0.0203993
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0202205
HM13 histocompatibility (minor) 13 -0.020195
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0201902
AGR2 anterior gradient 2 -0.0200802
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0198874
NDRG1 N-myc downstream regulated 1 -0.0195813
FNBP4 formin binding protein 4 -0.019467
S100A9 S100 calcium binding protein A9 -0.0193415