| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Crizotinib (hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Crizotinib (hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KRT18 | keratin 18, type I | 0.14035 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.139927 |
| CANX | calnexin | 0.132008 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.124178 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.1231 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.113973 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.111065 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.110537 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.109695 |
| LDHA | lactate dehydrogenase A | 0.0836262 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0809858 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0807714 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.079783 |
| PLAUR | plasminogen activator, urokinase receptor | 0.079733 |
| PGK1 | phosphoglycerate kinase 1 | 0.0759458 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0731481 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0702785 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0683498 |
| AHNAK | AHNAK nucleoprotein | 0.0637964 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0619744 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0588666 |
| HDLBP | high density lipoprotein binding protein | 0.0556536 |
| DSPP | dentin sialophosphoprotein | 0.0544422 |
| PLEC | plectin | 0.0524605 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0503167 |
| TMF1 | TATA element modulatory factor 1 | 0.0482792 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0474469 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0465705 |
| FDPS | farnesyl diphosphate synthase | 0.0456529 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0455889 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0446085 |
| KRT19 | keratin 19, type I | 0.0442145 |
| FLNA | filamin A, alpha | 0.0434782 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0434068 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0428184 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.04149 |
| YME1L1 | YME1-like 1 ATPase | 0.0408042 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0403523 |
| RPL7 | ribosomal protein L7 | 0.0386188 |
| ATF4 | activating transcription factor 4 | 0.0379947 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0379681 |
| GOLGA2 | golgin A2 | 0.0373944 |
| CALR | calreticulin | 0.036562 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0364999 |
| CORO1C | coronin, actin binding protein, 1C | 0.036232 |
| GOLGA4 | golgin A4 | 0.0357162 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.035156 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0350393 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0348963 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0346744 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.034622 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0346189 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0340506 |
| RIOK3 | RIO kinase 3 | 0.0340043 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.033872 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0335579 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0330442 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0329712 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.0327344 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0318225 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.031259 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0312107 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0311019 |
| CEP250 | centrosomal protein 250kDa | 0.0307922 |
| ENO1 | enolase 1, (alpha) | 0.0303188 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0302741 |
| EZR | ezrin | 0.0299046 |
| ACTN4 | actinin, alpha 4 | 0.0297997 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0296475 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0295281 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.0292981 |
| NUP58 | nucleoporin 58 | 0.0291093 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0290791 |
| VEGFA | vascular endothelial growth factor A | 0.028797 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0287724 |
| SQSTM1 | sequestosome 1 | 0.0287085 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0286267 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0284612 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0280131 |
| INSIG2 | insulin induced gene 2 | 0.0279925 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0277339 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0275564 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0274606 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0272746 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.027232 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0271881 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0270004 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0269496 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.02689 |
| NDRG1 | N-myc downstream regulated 1 | 0.0267544 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0267096 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0266821 |
| OGA | O-GlcNAcase | 0.026658 |
| GPR107 | G protein-coupled receptor 107 | 0.0266478 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0266203 |
| CNOT7 | CCR4-NOT transcription complex, subunit 7 | 0.0263427 |
| KIF5B | kinesin family member 5B | 0.0263315 |
| MATR3 | matrin 3 | 0.0263243 |
| FOXO3 | forkhead box O3 | 0.0263037 |
| RLF | rearranged L-myc fusion | 0.0262347 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGR1 | early growth response 1 | -0.0899973 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0824481 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0732656 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0688572 |
| TENM3 | teneurin transmembrane protein 3 | -0.049508 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0491524 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.044261 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0395733 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0360436 |
| FHIT | fragile histidine triad | -0.0349781 |
| RPL35A | ribosomal protein L35a | -0.0331134 |
| FAT1 | FAT atypical cadherin 1 | -0.0330126 |
| POTEF | POTE ankyrin domain family, member F | -0.0325126 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0324373 |
| TBC1D5 | TBC1 domain family, member 5 | -0.030538 |
| GPHN | gephyrin | -0.030396 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0286009 |
| SMYD3 | SET and MYND domain containing 3 | -0.0281061 |
| RPL34 | ribosomal protein L34 | -0.0276 |
| FRMD5 | FERM domain containing 5 | -0.0274781 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0265759 |
| SUMF1 | sulfatase modifying factor 1 | -0.0260846 |
| BPTF | bromodomain PHD finger transcription factor | -0.0256467 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0255116 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0254458 |
| ZNF518A | zinc finger protein 518A | -0.0239896 |
| INTS6 | integrator complex subunit 6 | -0.0238954 |
| SLC38A2 | solute carrier family 38, member 2 | -0.023794 |
| NFIA | nuclear factor I/A | -0.0236991 |
| TXNRD1 | thioredoxin reductase 1 | -0.0233621 |
| ACTG1 | actin gamma 1 | -0.0231097 |
| PARD3 | par-3 family cell polarity regulator | -0.0231069 |
| RPL37A | ribosomal protein L37a | -0.0228918 |
| HMGB1 | high mobility group box 1 | -0.0228192 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0227651 |
| VCL | vinculin | -0.0227572 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0224078 |
| RANBP17 | RAN binding protein 17 | -0.0224074 |
| CCND1 | cyclin D1 | -0.0220294 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0215558 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0214006 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0212297 |
| RPLP1 | ribosomal protein, large, P1 | -0.0212068 |
| TCF12 | transcription factor 12 | -0.0210133 |
| SCFD2 | sec1 family domain containing 2 | -0.0207504 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.020749 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0207293 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0206449 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0205452 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0204335 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0198385 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0197138 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0196801 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0195549 |
| TMSB10 | thymosin beta 10 | -0.0194551 |
| RPS13 | ribosomal protein S13 | -0.0193946 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | -0.0193789 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0193278 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0192544 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0190595 |
| AK1 | adenylate kinase 1 | -0.0190506 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0187166 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0186493 |
| ATM | ATM serine/threonine kinase | -0.0185338 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.0184201 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0183231 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0182701 |
| MSI2 | musashi RNA-binding protein 2 | -0.0181688 |
| ZNF638 | zinc finger protein 638 | -0.0181314 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0177192 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0176555 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0176492 |
| HMGA1 | high mobility group AT-hook 1 | -0.0175916 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0174311 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0173345 |
| COMMD10 | COMM domain containing 10 | -0.0172425 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0171451 |
| SRPK2 | SRSF protein kinase 2 | -0.0170708 |
| LRRC23 | leucine rich repeat containing 23 | -0.0167711 |
| AHI1 | Abelson helper integration site 1 | -0.0166992 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.016488 |
| NF1 | neurofibromin 1 | -0.0164825 |
| NKTR | natural killer cell triggering receptor | -0.0164382 |
| TBCA | tubulin folding cofactor A | -0.016338 |
| EXOC4 | exocyst complex component 4 | -0.016337 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0161944 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0161843 |
| LDHB | lactate dehydrogenase B | -0.0161475 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0161362 |
| ERBIN | erbb2 interacting protein | -0.0160413 |
| HMGA2 | high mobility group AT-hook 2 | -0.0160364 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0159577 |
| RPS29 | ribosomal protein S29 | -0.015783 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0156431 |
| CCNL1 | cyclin L1 | -0.0156389 |
| EHBP1 | EH domain binding protein 1 | -0.015594 |
| STK24 | serine/threonine kinase 24 | -0.0155272 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.015515 |
| FARS2 | phenylalanyl-tRNA synthetase 2, mitochondrial | -0.0154929 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0154452 |
