| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Crizotinib (hydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Crizotinib (hydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.518724 |
| COL6A3 | collagen, type VI, alpha 3 | 0.194351 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.172938 |
| VIM | vimentin | 0.132604 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0774825 |
| CANX | calnexin | 0.0749186 |
| FLNA | filamin A, alpha | 0.0705849 |
| VEGFA | vascular endothelial growth factor A | 0.0594803 |
| SQLE | squalene epoxidase | 0.0585414 |
| PLEC | plectin | 0.0510344 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0499186 |
| POSTN | periostin, osteoblast specific factor | 0.0494038 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0477664 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0473082 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0472506 |
| LOXL2 | lysyl oxidase-like 2 | 0.0472436 |
| APP | amyloid beta (A4) precursor protein | 0.0447801 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0365835 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0322957 |
| ATP13A3 | ATPase type 13A3 | 0.0301457 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0299591 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0293703 |
| CALR | calreticulin | 0.0278552 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0267578 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0267338 |
| NAV2 | neuron navigator 2 | 0.0260545 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0252439 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0241832 |
| ARRDC3 | arrestin domain containing 3 | 0.024018 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0237327 |
| COL3A1 | collagen, type III, alpha 1 | 0.0237267 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0229885 |
| SMAD3 | SMAD family member 3 | 0.0229088 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0223755 |
| CLIC4 | chloride intracellular channel 4 | 0.0221517 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0219208 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.02188 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0216662 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0215408 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0214071 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0210092 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0206435 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0202228 |
| LDHA | lactate dehydrogenase A | 0.0201191 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.0196587 |
| MSN | moesin | 0.0194111 |
| HYOU1 | hypoxia up-regulated 1 | 0.0191896 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0189027 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.018611 |
| FAT1 | FAT atypical cadherin 1 | 0.0185172 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0183411 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0181764 |
| ACLY | ATP citrate lyase | 0.0180115 |
| JCAD | junctional cadherin 5 associated | 0.017906 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0177699 |
| TMF1 | TATA element modulatory factor 1 | 0.0176202 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0175374 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0175121 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0174253 |
| LAMB1 | laminin, beta 1 | 0.0172946 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0171512 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0171036 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | 0.0170521 |
| TPM2 | tropomyosin 2 (beta) | 0.0167523 |
| INSIG1 | insulin induced gene 1 | 0.0166979 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0166951 |
| SERINC1 | serine incorporator 1 | 0.0165531 |
| SPAG9 | sperm associated antigen 9 | 0.0164542 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0163937 |
| GANAB | glucosidase, alpha; neutral AB | 0.0161463 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0161243 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.015507 |
| CASC3 | cancer susceptibility candidate 3 | 0.0152508 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0150424 |
| ITGA11 | integrin, alpha 11 | 0.0150109 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0149189 |
| RPN1 | ribophorin I | 0.0145817 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0144545 |
| ACTN4 | actinin, alpha 4 | 0.0142816 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0141854 |
| FYTTD1 | forty-two-three domain containing 1 | 0.0140835 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0140535 |
| RHOA | ras homolog family member A | 0.0138858 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0138573 |
| TMEM41B | transmembrane protein 41B | 0.0138115 |
| CORO1C | coronin, actin binding protein, 1C | 0.0137374 |
| RPL3 | ribosomal protein L3 | 0.0137171 |
| TPM3 | tropomyosin 3 | 0.0136921 |
| STC1 | stanniocalcin 1 | 0.0136064 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0135352 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0132283 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0131095 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0130716 |
| FMNL2 | formin-like 2 | 0.0129912 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0129058 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0128704 |
| TMSB4X | thymosin beta 4, X-linked | 0.0128293 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0126673 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0125915 |
| CMIP | c-Maf inducing protein | 0.0124765 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.208107 |
| MT2A | metallothionein 2A | -0.206443 |
| NDRG1 | N-myc downstream regulated 1 | -0.171961 |
| COL1A1 | collagen, type I, alpha 1 | -0.125561 |
| TMSB10 | thymosin beta 10 | -0.122237 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0878981 |
| CDH13 | cadherin 13 | -0.0745384 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0727256 |
| IER3 | immediate early response 3 | -0.0726681 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0705274 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0653667 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0639215 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0635239 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0597245 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0594433 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.056198 |
| CD44 | CD44 molecule (Indian blood group) | -0.055507 |
| RPL35A | ribosomal protein L35a | -0.0550154 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0506851 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0492787 |
| FTL | ferritin, light polypeptide | -0.0478888 |
| CADM1 | cell adhesion molecule 1 | -0.0470036 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0457159 |
| ACTG1 | actin gamma 1 | -0.0457093 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0447151 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0439945 |
| RPS8 | ribosomal protein S8 | -0.0438901 |
| EGFR | epidermal growth factor receptor | -0.0435004 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0434313 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0429435 |
| RPS6 | ribosomal protein S6 | -0.041634 |
| EGR1 | early growth response 1 | -0.0407051 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0405768 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0403356 |
| MT1X | metallothionein 1X | -0.0402441 |
| RPS19 | ribosomal protein S19 | -0.0394344 |
| GLIS3 | GLIS family zinc finger 3 | -0.0393723 |
| RPL28 | ribosomal protein L28 | -0.0387646 |
| LOX | lysyl oxidase | -0.0385461 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0379636 |
| HLA-B | major histocompatibility complex, class I, B | -0.0376504 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0362191 |
| PRELID2 | PRELI domain containing 2 | -0.0354055 |
| RPLP1 | ribosomal protein, large, P1 | -0.0352121 |
| RUNX1 | runt-related transcription factor 1 | -0.0351537 |
| S100A9 | S100 calcium binding protein A9 | -0.0342726 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.034062 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0329906 |
| ENO1 | enolase 1, (alpha) | -0.0318095 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0314585 |
| ATXN1 | ataxin 1 | -0.0314307 |
| RPLP2 | ribosomal protein, large, P2 | -0.0310969 |
| RPL36 | ribosomal protein L36 | -0.0306854 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.02999 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0293937 |
| SMYD3 | SET and MYND domain containing 3 | -0.0288732 |
| FOXP1 | forkhead box P1 | -0.0285683 |
| CNTN5 | contactin 5 | -0.0284387 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0280115 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0277358 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0277011 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0274335 |
| MTDH | metadherin | -0.0269775 |
| PTMA | prothymosin, alpha | -0.0265698 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0265051 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0264437 |
| B2M | beta-2-microglobulin | -0.0263987 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0261149 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0257315 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0256125 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0246424 |
| RPS21 | ribosomal protein S21 | -0.0244008 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0243284 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.024077 |
| RPL5 | ribosomal protein L5 | -0.0239792 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0239512 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0239297 |
| RPL37A | ribosomal protein L37a | -0.0238274 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0237518 |
| RPL32 | ribosomal protein L32 | -0.0236886 |
| CALD1 | caldesmon 1 | -0.0235302 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0231419 |
| RPS15 | ribosomal protein S15 | -0.0226961 |
| RPL8 | ribosomal protein L8 | -0.0225658 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0225647 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0223636 |
| POTEF | POTE ankyrin domain family, member F | -0.0217624 |
| DST | dystonin | -0.0212332 |
| RPL30 | ribosomal protein L30 | -0.0211925 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0210929 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0210168 |
| NAV1 | neuron navigator 1 | -0.0209356 |
| OSMR | oncostatin M receptor | -0.020912 |
| PDE10A | phosphodiesterase 10A | -0.0206743 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0205814 |
| PFN1 | profilin 1 | -0.0203911 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0203031 |
| RIGI | RNA sensor RIG-I | -0.0202987 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0201312 |
| RPL34 | ribosomal protein L34 | -0.0200978 |
