| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Crizotinib (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Crizotinib (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.194649 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.148632 |
| TF | transferrin | 0.14046 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.121236 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.117804 |
| FN1 | fibronectin 1 | 0.0771411 |
| DSPP | dentin sialophosphoprotein | 0.0682723 |
| APOB | apolipoprotein B | 0.0565901 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0535285 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0531287 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0524571 |
| EHBP1 | EH domain binding protein 1 | 0.0519548 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0518294 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0496952 |
| RNF213 | ring finger protein 213 | 0.048614 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0449173 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0435472 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.039666 |
| PEG3 | paternally expressed 3 | 0.0382435 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0378053 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0375048 |
| VCL | vinculin | 0.0362759 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0357467 |
| VEGFA | vascular endothelial growth factor A | 0.0354411 |
| TRIM26 | tripartite motif containing 26 | 0.0348598 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0331524 |
| KRT18 | keratin 18, type I | 0.0331298 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.032081 |
| TNS1 | tensin 1 | 0.0319498 |
| FRMD5 | FERM domain containing 5 | 0.0308215 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0307736 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0304657 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0303548 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0295263 |
| SMAD3 | SMAD family member 3 | 0.0294371 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0288578 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.0286807 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0277633 |
| ASPH | aspartate beta-hydroxylase | 0.0276876 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0273245 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0272771 |
| ATXN1 | ataxin 1 | 0.0271424 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0269467 |
| CFB | complement factor B | 0.0265222 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0261116 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0257513 |
| FAT1 | FAT atypical cadherin 1 | 0.0254178 |
| RIGI | RNA sensor RIG-I | 0.0252975 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0251136 |
| FMNL2 | formin-like 2 | 0.0246845 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0244441 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0244241 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0234348 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0230961 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0229867 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0229492 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.022732 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0225486 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0224599 |
| MRTFA | myocardin related transcription factor A | 0.0222564 |
| PLEC | plectin | 0.0220486 |
| CEP250 | centrosomal protein 250kDa | 0.0219931 |
| CANX | calnexin | 0.0216828 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0216556 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0215605 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0215424 |
| RNASET2 | ribonuclease T2 | 0.0215043 |
| GPC6 | glypican 6 | 0.0213739 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0213101 |
| ITGAV | integrin, alpha V | 0.020972 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0205846 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0203017 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0201352 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0200397 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0200027 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0199778 |
| LYZ | lysozyme | 0.0196155 |
| CRLS1 | cardiolipin synthase 1 | 0.0193471 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.0191716 |
| YME1L1 | YME1-like 1 ATPase | 0.0191334 |
| PTMA | prothymosin, alpha | 0.018951 |
| COL27A1 | collagen, type XXVII, alpha 1 | 0.0186278 |
| AFDN | afadin, adherens junction formation factor | 0.0186221 |
| FLNB | filamin B, beta | 0.0184714 |
| APP | amyloid beta (A4) precursor protein | 0.0183559 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0183107 |
| CALR | calreticulin | 0.0183079 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0181462 |
| SP100 | SP100 nuclear antigen | 0.0180399 |
| IL4R | interleukin 4 receptor | 0.0180204 |
| MCL1 | myeloid cell leukemia 1 | 0.0176816 |
| PLAC8 | placenta-specific 8 | 0.0176771 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0174527 |
| RAI14 | retinoic acid induced 14 | 0.0172232 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0170593 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0169554 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0169198 |
| CYTH1 | cytohesin 1 | 0.0168546 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0168367 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0168071 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.500701 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.425025 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.148786 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0661279 |
| RPS6 | ribosomal protein S6 | -0.0622598 |
| FTL | ferritin, light polypeptide | -0.049001 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0475158 |
| LOC112694756 | uncharaterized LOC112694756 | -0.042122 |
| RPLP1 | ribosomal protein, large, P1 | -0.0393456 |
| NDRG1 | N-myc downstream regulated 1 | -0.0348722 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0339708 |
| RPS8 | ribosomal protein S8 | -0.0327044 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0306301 |
| RPL34 | ribosomal protein L34 | -0.0304207 |
| GOLGA4 | golgin A4 | -0.0301507 |
| MT2A | metallothionein 2A | -0.0300317 |
| POTEF | POTE ankyrin domain family, member F | -0.0263944 |
| C3 | complement component 3 | -0.0255676 |
| RPS5 | ribosomal protein S5 | -0.0251899 |
| APOA2 | apolipoprotein A-II | -0.0247204 |
| HMGA1 | high mobility group AT-hook 1 | -0.0243822 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0242915 |
| RPL28 | ribosomal protein L28 | -0.0237498 |
| RPL5 | ribosomal protein L5 | -0.0229543 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.022681 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.02222 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0221798 |
| RPS14 | ribosomal protein S14 | -0.0221405 |
| WWC2 | WW and C2 domain containing 2 | -0.022088 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0218276 |
| AHSG | alpha-2-HS-glycoprotein | -0.021804 |
| RPLP0 | ribosomal protein, large, P0 | -0.0207748 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0207507 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0206286 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0201242 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0198148 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0197789 |
| GNAS | GNAS complex locus | -0.0196878 |
| RPS21 | ribosomal protein S21 | -0.0193642 |
| CST3 | cystatin C | -0.0189214 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0188309 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0187754 |
| ZNF207 | zinc finger protein 207 | -0.0187294 |
| RPS16 | ribosomal protein S16 | -0.018705 |
| APOA1 | apolipoprotein A-I | -0.0183022 |
| RPL27 | ribosomal protein L27 | -0.0178196 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0177398 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0176855 |
| ZFP36 | ZFP36 ring finger protein | -0.0176253 |
| RPS19 | ribosomal protein S19 | -0.0176172 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0173687 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.016819 |
| RPL9 | ribosomal protein L9 | -0.0167481 |
| RPS13 | ribosomal protein S13 | -0.0166589 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0160743 |
| CDK6 | cyclin-dependent kinase 6 | -0.0159685 |
| TMEM123 | transmembrane protein 123 | -0.0159149 |
| PUM2 | pumilio RNA-binding family member 2 | -0.015878 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0158732 |
| QKI | QKI, KH domain containing, RNA binding | -0.0157303 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0153088 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0152629 |
| RPS2 | ribosomal protein S2 | -0.0152027 |
| WDR45B | WD repeat domain 45B | -0.0151798 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.015166 |
| RPL30 | ribosomal protein L30 | -0.0151289 |
| SAMD8 | sterile alpha motif domain containing 8 | -0.0149596 |
| RBM25 | RNA binding motif protein 25 | -0.0148123 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0147988 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0147552 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.0147384 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0147366 |
| ZNF644 | zinc finger protein 644 | -0.0147254 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0146075 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0145174 |
| PDE8A | phosphodiesterase 8A | -0.0144271 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0143822 |
| FGG | fibrinogen gamma chain | -0.0143193 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0142816 |
| SMAP1 | small ArfGAP 1 | -0.01416 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0141487 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0140877 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.013744 |
| RACK1 | receptor for activated C kinase 1 | -0.0137303 |
| RPS20 | ribosomal protein S20 | -0.0136481 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0135391 |
| METTL9 | methyltransferase like 9 | -0.0135071 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0134572 |
| WASF2 | WAS protein family, member 2 | -0.0133829 |
| OGA | O-GlcNAcase | -0.0133006 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0133004 |
| ZNF292 | zinc finger protein 292 | -0.0132812 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0132174 |
| PFN1 | profilin 1 | -0.0132146 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0131231 |
| EPC1 | enhancer of polycomb homolog 1 (Drosophila) | -0.0130959 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0130501 |
| ATXN2L | ataxin 2-like | -0.0130097 |
| EGR1 | early growth response 1 | -0.0129996 |
| ZNF451 | zinc finger protein 451 | -0.0128748 |
