Crizotinib (hydrochloride)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Crizotinib (hydrochloride) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Crizotinib (hydrochloride)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.184469
CLU clusterin 0.115408
FLNA filamin A, alpha 0.110158
FLNB filamin B, beta 0.109282
PLEC plectin 0.106353
APLP2 amyloid beta (A4) precursor-like protein 2 0.101548
MSN moesin 0.0906266
CANX calnexin 0.0889629
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.079529
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0689506
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.066702
KRT17 keratin 17, type I 0.0657583
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0646661
LAMC2 laminin, gamma 2 0.057932
VCL vinculin 0.0536738
TMSB4X thymosin beta 4, X-linked 0.0525414
CEP250 centrosomal protein 250kDa 0.0515054
CTNND1 catenin (cadherin-associated protein), delta 1 0.0492445
BHLHE40 basic helix-loop-helix family, member e40 0.047792
TNIP1 TNFAIP3 interacting protein 1 0.0476116
HLA-E major histocompatibility complex, class I, E 0.047564
SMAD3 SMAD family member 3 0.0472711
RAI14 retinoic acid induced 14 0.0471397
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.047068
BLCAP bladder cancer associated protein 0.0451184
ARGLU1 arginine and glutamate rich 1 0.0439928
PGK1 phosphoglycerate kinase 1 0.0437892
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0435646
TPM3 tropomyosin 3 0.0422434
CALR calreticulin 0.041322
STC1 stanniocalcin 1 0.0409897
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0407799
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0402983
TMF1 TATA element modulatory factor 1 0.0384203
APP amyloid beta (A4) precursor protein 0.0379692
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0372016
CEMIP cell migration inducing protein, hyaluronan binding 0.0367061
CD9 CD9 molecule 0.0365914
MYO10 myosin X 0.0364988
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.03649
ARRDC3 arrestin domain containing 3 0.0360656
EHBP1L1 EH domain binding protein 1-like 1 0.0359388
RNF19B ring finger protein 19B 0.0357261
TIMP3 TIMP metallopeptidase inhibitor 3 0.0354526
CPNE1 copine I 0.0348595
SEPTIN9 septin 9 0.0346642
COL17A1 collagen, type XVII, alpha 1 0.0346491
MTSS1 metastasis suppressor 1 0.0342847
RPL7 ribosomal protein L7 0.0342836
NCOR2 nuclear receptor corepressor 2 0.0340913
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0333132
PLAT plasminogen activator, tissue 0.0328349
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0325123
PDLIM1 PDZ and LIM domain 1 0.0322972
FOXO1 forkhead box O1 0.0322555
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0321342
FAM107B family with sequence similarity 107, member B 0.0320588
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0318591
PDIA4 protein disulfide isomerase family A, member 4 0.0316857
MCL1 myeloid cell leukemia 1 0.0313705
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0313614
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0309721
RPS4X ribosomal protein S4, X-linked 0.0307405
LUZP1 leucine zipper protein 1 0.0307194
MACF1 microtubule-actin crosslinking factor 1 0.030314
CD44 CD44 molecule (Indian blood group) 0.0299884
KRT18 keratin 18, type I 0.0293951
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0293417
KTN1 kinectin 1 (kinesin receptor) 0.0291904
KRT14 keratin 14, type I 0.028957
AHNAK2 AHNAK nucleoprotein 2 0.0287542
EEF2 eukaryotic translation elongation factor 2 0.0286687
ITPRID2 ITPR interacting domain containing 2 0.0284144
SAMD9 sterile alpha motif domain containing 9 0.0278468
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0277241
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.0270362
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0269647
HDGF hepatoma-derived growth factor 0.0268205
AHNAK AHNAK nucleoprotein 0.0265328
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0261883
SERINC1 serine incorporator 1 0.025579
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.025297
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0251851
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0251631
FNDC3B fibronectin type III domain containing 3B 0.0248994
AKAP13 A kinase (PRKA) anchor protein 13 0.0247761
SH3PXD2A SH3 and PX domains 2A 0.0245973
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0245135
NFE2L1 nuclear factor, erythroid 2-like 1 0.0244194
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0243657
SLK STE20-like kinase 0.0243168
RPL4 ribosomal protein L4 0.0240441
ANXA11 annexin A11 0.0239205
LMO7 LIM domain 7 0.0238506
SRRM2 serine/arginine repetitive matrix 2 0.0238002
CAPN2 calpain 2, (m/II) large subunit 0.0237766
CALU calumenin 0.0237215
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0237183
PRPF6 pre-mRNA processing factor 6 0.0233943
SLC35H1 solute carrier family 35 member H1 0.0232412

decreased expression

Symbol Name Standardized Value
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.190656
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.185939
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.15021
DPYD dihydropyrimidine dehydrogenase -0.121884
NDRG1 N-myc downstream regulated 1 -0.102276
POTEF POTE ankyrin domain family, member F -0.0908625
IGF2 insulin-like growth factor 2 -0.0783743
TMSB10 thymosin beta 10 -0.0677263
S100A10 S100 calcium binding protein A10 -0.0589267
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0579142
GNAS GNAS complex locus -0.0577882
INTS6 integrator complex subunit 6 -0.0525114
LOC112694756 uncharaterized LOC112694756 -0.0480697
HSPG2 heparan sulfate proteoglycan 2 -0.0456855
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0424917
PDLIM5 PDZ and LIM domain 5 -0.0423776
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0402719
RPS21 ribosomal protein S21 -0.0399122
ANXA1 annexin A1 -0.0389111
MT1X metallothionein 1X -0.0384172
LAMA5 laminin, alpha 5 -0.0356499
SULF2 sulfatase 2 -0.0351013
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0344534
PTK2 protein tyrosine kinase 2 -0.0343566
EGR1 early growth response 1 -0.0338891
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0338436
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0333728
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0329508
TRIO trio Rho guanine nucleotide exchange factor -0.0327423
MECOM MDS1 and EVI1 complex locus -0.0320055
FOXP1 forkhead box P1 -0.0317232
ALCAM activated leukocyte cell adhesion molecule -0.0311459
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0310923
MBNL1 muscleblind-like splicing regulator 1 -0.0305312
CAV1 caveolin 1, caveolae protein, 22kDa -0.0298542
PALLD palladin, cytoskeletal associated protein -0.0282576
RPLP1 ribosomal protein, large, P1 -0.0279155
LMNA lamin A/C -0.0278549
ARF1 ADP-ribosylation factor 1 -0.027588
IFITM3 interferon induced transmembrane protein 3 -0.0275151
RASAL2 RAS protein activator like 2 -0.0266887
PFN1 profilin 1 -0.0265355
RPL28 ribosomal protein L28 -0.026418
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0263362
COL4A5 collagen, type IV, alpha 5 -0.0261336
QKI QKI, KH domain containing, RNA binding -0.0260916
H1-0 H1.0 linker histone -0.0258821
RPL34 ribosomal protein L34 -0.025547
RIGI RNA sensor RIG-I -0.0250441
RPL35A ribosomal protein L35a -0.0247051
CNTNAP3 contactin associated protein-like 3 -0.0245972
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0244203
ITCH itchy E3 ubiquitin protein ligase -0.0241969
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0241719
CORO2A coronin, actin binding protein, 2A -0.0241349
VDAC1 voltage-dependent anion channel 1 -0.0237442
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0237346
NRCAM neuronal cell adhesion molecule -0.023663
SDCBP syndecan binding protein (syntenin) -0.0236626
FSCN1 fascin actin-bundling protein 1 -0.0233651
RABGAP1L RAB GTPase activating protein 1-like -0.0233346
RBM39 RNA binding motif protein 39 -0.0231325
SULF1 sulfatase 1 -0.0228431
RPS24 ribosomal protein S24 -0.0226448
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0225516
YBX3 Y box binding protein 3 -0.0222912
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0221037
EXOC4 exocyst complex component 4 -0.021833
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0218284
SOX5 SRY (sex determining region Y)-box 5 -0.021814
RPL30 ribosomal protein L30 -0.0217603
IFI44 interferon-induced protein 44 -0.0217337
RPL8 ribosomal protein L8 -0.0214971
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0214415
S100A2 S100 calcium binding protein A2 -0.021219
RTN4 reticulon 4 -0.0211826
PRELID2 PRELI domain containing 2 -0.0208112
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0208019
MT2A metallothionein 2A -0.0207243
PIBF1 progesterone immunomodulatory binding factor 1 -0.0206628
ADNP activity-dependent neuroprotector homeobox -0.0205271
ANO1 anoctamin 1, calcium activated chloride channel -0.0205234
NPEPPS aminopeptidase puromycin sensitive -0.0202802
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0201301
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0200893
TXNRD1 thioredoxin reductase 1 -0.020003
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0195872
ANKHD1 ankyrin repeat and KH domain containing 1 -0.019453
NFIA nuclear factor I/A -0.0194309
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0193522
RAD51B RAD51 paralog B -0.0191025
CNRIP1 cannabinoid receptor interacting protein 1 -0.0190822
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0190693
TMEM135 transmembrane protein 135 -0.0189813
HMGA2 high mobility group AT-hook 2 -0.0188377
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0186894
VAMP3 vesicle-associated membrane protein 3 -0.0186131
RAB2A RAB2A, member RAS oncogene family -0.0185543
RPS6 ribosomal protein S6 -0.0185015
ANKRD10 ankyrin repeat domain 10 -0.0184716