Crizotinib (hydrochloride)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Crizotinib (hydrochloride) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Crizotinib (hydrochloride)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT18 keratin 18, type I 0.174273
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.149657
PIGR polymeric immunoglobulin receptor 0.149367
SPTBN1 spectrin, beta, non-erythrocytic 1 0.143609
PABPC1 poly(A) binding protein, cytoplasmic 1 0.136185
FAT1 FAT atypical cadherin 1 0.114246
MYH9 myosin, heavy chain 9, non-muscle 0.106897
VEGFA vascular endothelial growth factor A 0.0997665
DSPP dentin sialophosphoprotein 0.0984266
PTMA prothymosin, alpha 0.0948765
AREG amphiregulin 0.0868576
CANX calnexin 0.0811561
MACF1 microtubule-actin crosslinking factor 1 0.0749609
MUC17 mucin 17, cell surface associated 0.0712546
PGK1 phosphoglycerate kinase 1 0.0679063
MYO1E myosin IE 0.0640235
RPL7 ribosomal protein L7 0.0630707
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0603145
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0540878
APP amyloid beta (A4) precursor protein 0.0533637
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.053007
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0528401
ITPRID2 ITPR interacting domain containing 2 0.0527669
PDIA4 protein disulfide isomerase family A, member 4 0.052458
CALR calreticulin 0.0514753
LMO7 LIM domain 7 0.0510542
ACTN4 actinin, alpha 4 0.0492372
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0475337
EEF2 eukaryotic translation elongation factor 2 0.0461818
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0461811
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0450626
ANXA11 annexin A11 0.0438843
KRT19 keratin 19, type I 0.0435123
EIF4B eukaryotic translation initiation factor 4B 0.0429379
DSCAM Down syndrome cell adhesion molecule 0.0425062
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0424707
MLEC malectin 0.0417881
RPL13A ribosomal protein L13a 0.0414338
CDPF1 cysteine-rich, DPF motif domain containing 1 0.041163
EIF1 eukaryotic translation initiation factor 1 0.0407128
CTNND1 catenin (cadherin-associated protein), delta 1 0.0401183
NCOR2 nuclear receptor corepressor 2 0.0397759
RPL11 ribosomal protein L11 0.039682
ATF4 activating transcription factor 4 0.0393018
FLNB filamin B, beta 0.0389039
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0381575
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.037859
LDHA lactate dehydrogenase A 0.036715
RPS4X ribosomal protein S4, X-linked 0.0365902
TMSB4X thymosin beta 4, X-linked 0.0359799
RPS3 ribosomal protein S3 0.0354239
EPCAM epithelial cell adhesion molecule 0.0352486
SEPTIN9 septin 9 0.0352164
SREBF2 sterol regulatory element binding transcription factor 2 0.0351006
NUMA1 nuclear mitotic apparatus protein 1 0.0350656
MED13 mediator complex subunit 13 0.0350245
ZC3H11A zinc finger CCCH-type containing 11A 0.0350051
RPL4 ribosomal protein L4 0.034758
UBC ubiquitin C 0.034565
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0342669
LOC102724023 ES1 protein homolog, mitochondrial 0.0336776
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0336518
PLEC plectin 0.0336475
PTPRF protein tyrosine phosphatase, receptor type, F 0.0332299
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0327025
FAM13A family with sequence similarity 13, member A 0.0322373
KRT8 keratin 8, type II 0.0320952
FDPS farnesyl diphosphate synthase 0.0319521
MYH14 myosin, heavy chain 14, non-muscle 0.0315504
EIF4A1 eukaryotic translation initiation factor 4A1 0.0309485
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0308763
RPL19 ribosomal protein L19 0.0307992
ABHD2 abhydrolase domain containing 2 0.0305637
KDM3A lysine (K)-specific demethylase 3A 0.0297397
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0292726
RPL3 ribosomal protein L3 0.0292054
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0291092
MYO10 myosin X 0.0286584
SRRM2 serine/arginine repetitive matrix 2 0.0281831
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0279877
ARGLU1 arginine and glutamate rich 1 0.0279847
RPLP0 ribosomal protein, large, P0 0.0279728
BACE2 beta-site APP-cleaving enzyme 2 0.0278978
HSPA8 heat shock 70kDa protein 8 0.0276703
TXNIP thioredoxin interacting protein 0.027385
RAB6A RAB6A, member RAS oncogene family 0.0273464
YME1L1 YME1-like 1 ATPase 0.0273013
EEF1G eukaryotic translation elongation factor 1 gamma 0.0270507
RPS23 ribosomal protein S23 0.026882
RPS27A ribosomal protein S27a 0.0268644
JARID2 jumonji, AT rich interactive domain 2 0.0265943
HYOU1 hypoxia up-regulated 1 0.0263533
IQGAP1 IQ motif containing GTPase activating protein 1 0.0261604
ARHGAP5 Rho GTPase activating protein 5 0.0257943
RNF145 ring finger protein 145 0.0256649
THRAP3 thyroid hormone receptor associated protein 3 0.0254533
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0250545
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0248096
ATP5F1A ATP synthase F1 subunit alpha 0.0247322
ANKRD17 ankyrin repeat domain 17 0.0246434

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.110978
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0943268
NPSR1 neuropeptide S receptor 1 -0.0742639
NALF1 NALCN channel auxiliary factor 1 -0.0604479
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0547118
POTEF POTE ankyrin domain family, member F -0.0517673
PDIA3 protein disulfide isomerase family A, member 3 -0.0504654
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0465752
HMGB1 high mobility group box 1 -0.0444494
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0438902
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0425842
ANXA2 annexin A2 -0.0403861
TMSB10 thymosin beta 10 -0.0398427
NDRG1 N-myc downstream regulated 1 -0.0393233
HMGA1 high mobility group AT-hook 1 -0.0386139
ACTG1 actin gamma 1 -0.0356376
TNS4 tensin 4 -0.035341
TAS2R14 taste receptor, type 2, member 14 -0.0350521
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0346118
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0333156
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0328871
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0317054
GMDS GDP-mannose 4,6-dehydratase -0.0311724
ZNF292 zinc finger protein 292 -0.0299728
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0292115
COG5 component of oligomeric golgi complex 5 -0.0290199
AGR2 anterior gradient 2 -0.0286501
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0284962
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0284331
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0282818
CCND1 cyclin D1 -0.0258993
SMYD3 SET and MYND domain containing 3 -0.0257879
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0256692
FHIT fragile histidine triad -0.0254409
NRXN3 neurexin 3 -0.0254008
H1-0 H1.0 linker histone -0.0252897
RAD51B RAD51 paralog B -0.0252473
BPTF bromodomain PHD finger transcription factor -0.0247975
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0237697
RPS6 ribosomal protein S6 -0.0230869
FOSL1 FOS-like antigen 1 -0.0229616
IARS1 isoleucyl-tRNA synthetase 1 -0.0226554
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0226537
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0224066
FAF1 Fas (TNFRSF6) associated factor 1 -0.0223274
PARD3B par-3 family cell polarity regulator beta -0.0222467
GPHN gephyrin -0.0221536
SMC4 structural maintenance of chromosomes 4 -0.0219672
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0218444
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.021813
SLC35F3 solute carrier family 35, member F3 -0.0218018
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0215929
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0214647
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0211548
SBF2 SET binding factor 2 -0.0210019
TFRC transferrin receptor -0.0209366
IFRD1 interferon-related developmental regulator 1 -0.0209108
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0208731
SRPK2 SRSF protein kinase 2 -0.0206767
NBAS neuroblastoma amplified sequence -0.0206526
SPDYA speedy/RINGO cell cycle regulator family member A -0.0205865
DLG1 discs, large homolog 1 (Drosophila) -0.0203875
NAMPT nicotinamide phosphoribosyltransferase -0.0201653
EGR1 early growth response 1 -0.020068
DYM dymeclin -0.019981
MBNL2 muscleblind-like splicing regulator 2 -0.0199069
RYBP RING1 and YY1 binding protein -0.0198403
CENPE centromere protein E, 312kDa -0.0196172
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0196155
TXNRD1 thioredoxin reductase 1 -0.0196001
PTEN phosphatase and tensin homolog -0.0194226
MBD5 methyl-CpG binding domain protein 5 -0.0192615
ONECUT3 one cut homeobox 3 -0.0192571
RPL34 ribosomal protein L34 -0.0192265
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0190594
MGST1 microsomal glutathione S-transferase 1 -0.0189187
ECT2 epithelial cell transforming 2 -0.0188762
RTN3 reticulon 3 -0.0188468
EVI5 ecotropic viral integration site 5 -0.0186022
VDAC1 voltage-dependent anion channel 1 -0.0185702
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0184125
PDE4D phosphodiesterase 4D, cAMP-specific -0.0183896
RPS24 ribosomal protein S24 -0.0182861
SERBP1 SERPINE1 mRNA binding protein 1 -0.018155
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0180093
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0177714
SCLT1 sodium channel and clathrin linker 1 -0.0177209
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.017394
CADPS2 Ca++-dependent secretion activator 2 -0.0173791
LOC112694756 uncharaterized LOC112694756 -0.0173673
NFIA nuclear factor I/A -0.0172861
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0172858
RNF13 ring finger protein 13 -0.0171665
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0170906
TUBA1B tubulin, alpha 1b -0.0170726
SKAP2 src kinase associated phosphoprotein 2 -0.016949
CAMKMT calmodulin-lysine N-methyltransferase -0.0169467
RFX7 regulatory factor X, 7 -0.0167827
CENPF centromere protein F, 350/400kDa -0.0167712
VWA8 von Willebrand factor A domain containing 8 -0.0167354