Crizotinib (hydrochloride)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Crizotinib (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Crizotinib (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.169184
PABPC1 poly(A) binding protein, cytoplasmic 1 0.165038
TPT1 tumor protein, translationally-controlled 1 0.115345
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0925695
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0802864
KRT18 keratin 18, type I 0.0802819
EEF2 eukaryotic translation elongation factor 2 0.0774373
CANX calnexin 0.0760786
RPL4 ribosomal protein L4 0.0745914
MYH9 myosin, heavy chain 9, non-muscle 0.072588
RPLP0 ribosomal protein, large, P0 0.0708216
DSPP dentin sialophosphoprotein 0.0661607
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0653465
FAT1 FAT atypical cadherin 1 0.060097
RPL7 ribosomal protein L7 0.0562682
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.055229
ITPRID2 ITPR interacting domain containing 2 0.0550738
SHROOM3 shroom family member 3 0.0542652
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.052816
TSPAN8 tetraspanin 8 0.0499395
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0493356
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0490479
LOC105378220 macrophage receptor MARCO-like 0.0489267
LAMB3 laminin, beta 3 0.048731
RPS4X ribosomal protein S4, X-linked 0.0445138
RPS23 ribosomal protein S23 0.0439242
RPS27A ribosomal protein S27a 0.0438437
PGK1 phosphoglycerate kinase 1 0.0434339
EIF1 eukaryotic translation initiation factor 1 0.0418334
LDHA lactate dehydrogenase A 0.041751
UBC ubiquitin C 0.0415847
EZR ezrin 0.0404594
HSPA8 heat shock 70kDa protein 8 0.0391908
RPL14 ribosomal protein L14 0.0384367
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0384233
PDIA4 protein disulfide isomerase family A, member 4 0.0377444
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0370709
RPS12 ribosomal protein S12 0.0366945
EIF4B eukaryotic translation initiation factor 4B 0.0365519
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0364004
PRELID2 PRELI domain containing 2 0.0362541
NCOR2 nuclear receptor corepressor 2 0.0361446
RPL13A ribosomal protein L13a 0.035795
TMF1 TATA element modulatory factor 1 0.0355509
LMO7 LIM domain 7 0.0350774
KRT8 keratin 8, type II 0.0346564
P4HB prolyl 4-hydroxylase, beta polypeptide 0.034566
HDLBP high density lipoprotein binding protein 0.0339178
CTNND1 catenin (cadherin-associated protein), delta 1 0.0336714
HLA-E major histocompatibility complex, class I, E 0.0335645
ATF4 activating transcription factor 4 0.0331267
MACF1 microtubule-actin crosslinking factor 1 0.0325884
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0321438
PTPRR protein tyrosine phosphatase, receptor type, R 0.0320257
TNIP1 TNFAIP3 interacting protein 1 0.0316028
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0314173
RPL27A ribosomal protein L27a 0.0312939
GDF15 growth differentiation factor 15 0.0312831
KLF5 Kruppel-like factor 5 (intestinal) 0.0310874
DSCAM Down syndrome cell adhesion molecule 0.0307504
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0296972
BACE2 beta-site APP-cleaving enzyme 2 0.0294865
YME1L1 YME1-like 1 ATPase 0.029394
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0289762
RPS3 ribosomal protein S3 0.0288543
CALU calumenin 0.0287613
AREG amphiregulin 0.0285674
RSL1D1 ribosomal L1 domain containing 1 0.0285215
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0282334
EEF1G eukaryotic translation elongation factor 1 gamma 0.0282003
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0281748
EIF4A2 eukaryotic translation initiation factor 4A2 0.0275457
MAP2K1 mitogen-activated protein kinase kinase 1 0.0272466
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0269985
ACTN4 actinin, alpha 4 0.0268839
RPL11 ribosomal protein L11 0.0265696
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0265276
MKI67 marker of proliferation Ki-67 0.026503
GOLGA3 golgin A3 0.0264843
CALR calreticulin 0.0264629
BHLHE40 basic helix-loop-helix family, member e40 0.0255253
ARGLU1 arginine and glutamate rich 1 0.0254609
MLEC malectin 0.0254217
RRBP1 ribosome binding protein 1 0.0253472
LIMA1 LIM domain and actin binding 1 0.0248905
KDM7A lysine (K)-specific demethylase 7A 0.024555
RPS17 ribosomal protein S17 0.0244578
ZC3H11A zinc finger CCCH-type containing 11A 0.0243387
EGFR epidermal growth factor receptor 0.0243232
BMP4 bone morphogenetic protein 4 0.0242887
RPL36A ribosomal protein L36a 0.0241128
KLF6 Kruppel-like factor 6 0.0234814
AARS1 alanyl-tRNA synthetase 1 0.0233155
RPL3 ribosomal protein L3 0.0231055
FRMD5 FERM domain containing 5 0.0229622
PTMA prothymosin, alpha 0.0228964
RPS8 ribosomal protein S8 0.022785
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0227348
KDM3A lysine (K)-specific demethylase 3A 0.0226632
ACBD3 acyl-CoA binding domain containing 3 0.0222232

decreased expression

Symbol Name Standardized Value
THSD4 thrombospondin, type I, domain containing 4 -0.136684
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.111243
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.109608
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0842973
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.074261
POTEF POTE ankyrin domain family, member F -0.0712546
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0707865
FLNB filamin B, beta -0.069783
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0630965
PTPRK protein tyrosine phosphatase, receptor type, K -0.0603075
AHCYL2 adenosylhomocysteinase-like 2 -0.0582824
MYOF myoferlin -0.0572867
PTPRG protein tyrosine phosphatase, receptor type, G -0.0554209
TMSB10 thymosin beta 10 -0.0548573
ITGA6 integrin, alpha 6 -0.0544768
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0539765
MSI2 musashi RNA-binding protein 2 -0.0536131
TC2N tandem C2 domains, nuclear -0.0518692
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0517005
COG5 component of oligomeric golgi complex 5 -0.0511347
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0510659
TXNRD1 thioredoxin reductase 1 -0.0496885
ANXA2 annexin A2 -0.0480045
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0474523
RIMKLB ribosomal modification protein rimK-like family member B -0.0473641
P3H2 prolyl 3-hydroxylase 2 -0.0473136
ARHGAP26 Rho GTPase activating protein 26 -0.0462337
RNF213 ring finger protein 213 -0.0443312
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0435251
IARS1 isoleucyl-tRNA synthetase 1 -0.0423794
TRIM2 tripartite motif containing 2 -0.0419476
UBE2H ubiquitin-conjugating enzyme E2H -0.0418762
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0407582
MX2 MX dynamin-like GTPase 2 -0.0404985
RIGI RNA sensor RIG-I -0.0395391
MX1 MX dynamin-like GTPase 1 -0.0394357
MON2 MON2 homolog (S. cerevisiae) -0.0390357
ACTG1 actin gamma 1 -0.0385347
PRSS3 protease, serine, 3 -0.038494
STAT1 signal transducer and activator of transcription 1, 91kDa -0.038281
EGR1 early growth response 1 -0.0376918
GMDS GDP-mannose 4,6-dehydratase -0.0364003
NF1 neurofibromin 1 -0.0355831
TSC22D2 TSC22 domain family, member 2 -0.0352211
SLC38A2 solute carrier family 38, member 2 -0.0350422
SMC4 structural maintenance of chromosomes 4 -0.034941
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) -0.0347204
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.0343047
WARS1 tryptophanyl-tRNA synthetase 1 -0.0334809
FER fer (fps/fes related) tyrosine kinase -0.0334415
CATSPERB catsper channel auxiliary subunit beta -0.033406
OXSR1 oxidative stress responsive 1 -0.0332039
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0326156
RAP1B RAP1B, member of RAS oncogene family -0.0325082
ANKRD11 ankyrin repeat domain 11 -0.0323945
GPHN gephyrin -0.032394
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.032345
BPTF bromodomain PHD finger transcription factor -0.0321399
SP100 SP100 nuclear antigen -0.0317958
TAS2R14 taste receptor, type 2, member 14 -0.0314469
LAMA4 laminin, alpha 4 -0.0314396
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0312611
FAF1 Fas (TNFRSF6) associated factor 1 -0.0311744
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0311078
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0308497
TCERG1 transcription elongation regulator 1 -0.0303923
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0302964
EXOC4 exocyst complex component 4 -0.0302905
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.030069
PDE4D phosphodiesterase 4D, cAMP-specific -0.0297524
DSG3 desmoglein 3 -0.0295151
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0290265
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0290205
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0285637
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0285631
RTN4 reticulon 4 -0.0284325
PLSCR1 phospholipid scramblase 1 -0.0283739
PKM pyruvate kinase, muscle -0.028323
RAD51B RAD51 paralog B -0.0282473
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0276513
ETNK1 ethanolamine kinase 1 -0.0271264
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0271056
MAML2 mastermind-like 2 (Drosophila) -0.0270848
KMT2E lysine (K)-specific methyltransferase 2E -0.0270272
SRPK2 SRSF protein kinase 2 -0.0266517
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0265108
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0261368
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0260898
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0260697
PALLD palladin, cytoskeletal associated protein -0.0259805
MYO1E myosin IE -0.025972
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0259504
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0258643
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0258369
PCDHB16 protocadherin beta 16 -0.0256184
RANBP17 RAN binding protein 17 -0.0252843
PHF14 PHD finger protein 14 -0.0252086
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0251836
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0251782
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0247528