Crizotinib (hydrochloride)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Crizotinib (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Crizotinib (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.238601
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.108231
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.100119
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0997046
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0955579
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.087791
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0869926
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0857084
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0759875
CANX calnexin 0.0715981
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0705761
APP amyloid beta (A4) precursor protein 0.0658843
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0655624
CALR calreticulin 0.0624606
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0582228
PTMA prothymosin, alpha 0.0578515
RPS4Y1 ribosomal protein S4, Y-linked 1 0.057588
TPM3 tropomyosin 3 0.0575165
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0556539
AKAP12 A kinase (PRKA) anchor protein 12 0.0548729
KDM3A lysine (K)-specific demethylase 3A 0.0543206
RPL4 ribosomal protein L4 0.0518539
MYH9 myosin, heavy chain 9, non-muscle 0.0490066
FLNA filamin A, alpha 0.0484274
MYOF myoferlin 0.0450389
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0442556
YME1L1 YME1-like 1 ATPase 0.0440394
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0439517
EEF2 eukaryotic translation elongation factor 2 0.043799
BASP1 brain abundant, membrane attached signal protein 1 0.0434561
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0422018
RBM8A RNA binding motif protein 8A 0.0421631
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0414434
MACF1 microtubule-actin crosslinking factor 1 0.0410813
HSPA8 heat shock 70kDa protein 8 0.0407801
MCL1 myeloid cell leukemia 1 0.0398559
UBASH3B ubiquitin associated and SH3 domain containing B 0.039573
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0377177
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0374243
CAVIN1 caveolae associated protein 1 0.0366694
PAWR PRKC, apoptosis, WT1, regulator 0.0362961
HYOU1 hypoxia up-regulated 1 0.0348771
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0347748
LDHA lactate dehydrogenase A 0.0336072
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0332586
EIF4A1 eukaryotic translation initiation factor 4A1 0.0321651
TRIO trio Rho guanine nucleotide exchange factor 0.0320406
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0318799
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0318191
NAMPT nicotinamide phosphoribosyltransferase 0.0318151
EEF1G eukaryotic translation elongation factor 1 gamma 0.031713
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0312781
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0309047
RPL13A ribosomal protein L13a 0.0305927
RPS3 ribosomal protein S3 0.0302793
WAC WW domain containing adaptor with coiled-coil 0.0301921
ERRFI1 ERBB receptor feedback inhibitor 1 0.0296261
IQGAP1 IQ motif containing GTPase activating protein 1 0.0295715
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0294865
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0291078
SAMD4A sterile alpha motif domain containing 4A 0.0290402
NAP1L1 nucleosome assembly protein 1-like 1 0.0289188
ANXA1 annexin A1 0.0282774
TPM4 tropomyosin 4 0.0278406
THBS1 thrombospondin 1 0.0276554
COPA coatomer protein complex, subunit alpha 0.0275269
LAMB1 laminin, beta 1 0.027187
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0269037
JAK1 Janus kinase 1 0.0267585
FAM107B family with sequence similarity 107, member B 0.026505
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0264797
FLNB filamin B, beta 0.0263866
CYTH1 cytohesin 1 0.0258084
FMNL2 formin-like 2 0.0256881
CSNK1A1 casein kinase 1, alpha 1 0.025302
HDGF hepatoma-derived growth factor 0.0252699
CASC3 cancer susceptibility candidate 3 0.0252185
VCL vinculin 0.0252102
TPD52 tumor protein D52 0.0251409
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0249995
HDAC9 histone deacetylase 9 0.0247003
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0246925
RPL7 ribosomal protein L7 0.0246011
RSL1D1 ribosomal L1 domain containing 1 0.0240231
PLS3 plastin 3 0.0235712
SFTPA2 surfactant protein A2 0.02345
JUN jun proto-oncogene 0.0231894
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0229723
SVIL supervillin 0.0228984
FAM168A family with sequence similarity 168, member A 0.0227696
RPL3 ribosomal protein L3 0.0227523
DGKD diacylglycerol kinase, delta 130kDa 0.022712
PDIA6 protein disulfide isomerase family A, member 6 0.0226496
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.0224413
FGB fibrinogen beta chain 0.0224034
FNDC3B fibronectin type III domain containing 3B 0.0222919
NQO1 NAD(P)H dehydrogenase, quinone 1 0.022289
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0220383
YBX1 Y box binding protein 1 0.0220365
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0219766

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.479746
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.333617
TMSB10 thymosin beta 10 -0.127439
TM4SF1 transmembrane 4 L six family member 1 -0.076023
IGF2 insulin-like growth factor 2 -0.0744673
RPS21 ribosomal protein S21 -0.0644814
ACTG1 actin gamma 1 -0.060849
FTL ferritin, light polypeptide -0.0589156
RPLP1 ribosomal protein, large, P1 -0.0546184
PDE4D phosphodiesterase 4D, cAMP-specific -0.0539325
GRAMD1B GRAM domain containing 1B -0.0523966
POTEF POTE ankyrin domain family, member F -0.0498691
PFN1 profilin 1 -0.0439847
RPL35A ribosomal protein L35a -0.0436344
RPS15 ribosomal protein S15 -0.0409105
RPS19 ribosomal protein S19 -0.0382285
STC1 stanniocalcin 1 -0.0363217
TXNRD1 thioredoxin reductase 1 -0.035338
RPS29 ribosomal protein S29 -0.0344237
RPL36 ribosomal protein L36 -0.0321587
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0319302
RPL31 ribosomal protein L31 -0.0293402
HLA-B major histocompatibility complex, class I, B -0.0284204
RPL9 ribosomal protein L9 -0.0284169
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0277823
RPS5 ribosomal protein S5 -0.0256518
ATP5F1E ATP synthase F1 subunit epsilon -0.0255637
NRG1 neuregulin 1 -0.025063
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0250427
RPS23 ribosomal protein S23 -0.0248955
RPS8 ribosomal protein S8 -0.0248582
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0246827
RPS16 ribosomal protein S16 -0.0246166
S100A10 S100 calcium binding protein A10 -0.0244153
RPL34 ribosomal protein L34 -0.0240899
RPL32 ribosomal protein L32 -0.0240379
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0234766
IER3 immediate early response 3 -0.0232213
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0231731
RPL28 ribosomal protein L28 -0.0227209
RPS27 ribosomal protein S27 -0.0220935
RPS6 ribosomal protein S6 -0.0219719
ANKRD12 ankyrin repeat domain 12 -0.0217712
EGR1 early growth response 1 -0.0214399
NNMT nicotinamide N-methyltransferase -0.0208115
RPL30 ribosomal protein L30 -0.0206603
RPL8 ribosomal protein L8 -0.0196561
MIS18BP1 MIS18 binding protein 1 -0.019631
S100A6 S100 calcium binding protein A6 -0.0195385
RPL12 ribosomal protein L12 -0.0195046
BIRC3 baculoviral IAP repeat containing 3 -0.019479
S100A11 S100 calcium binding protein A11 -0.0190212
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0189549
RPS13 ribosomal protein S13 -0.0186423
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0184743
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0184632
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0183882
AREG amphiregulin -0.0179383
CENPE centromere protein E, 312kDa -0.0178244
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0176448
PRDX1 peroxiredoxin 1 -0.0176039
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.017515
RPLP2 ribosomal protein, large, P2 -0.0173489
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0170784
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0169974
RPS27A ribosomal protein S27a -0.0169637
C15ORF48 chromosome 15 open reading frame 48 -0.0169184
RTN4 reticulon 4 -0.0165739
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0165242
SLC38A1 solute carrier family 38, member 1 -0.0163704
RPS20 ribosomal protein S20 -0.016277
RPLP0 ribosomal protein, large, P0 -0.0162401
ASTN2 astrotactin 2 -0.0157996
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0153184
CENPF centromere protein F, 350/400kDa -0.0152364
TUBB4B tubulin, beta 4B class IVb -0.0151181
HMGB1 high mobility group box 1 -0.0142971
EIF1 eukaryotic translation initiation factor 1 -0.0142461
OSMR oncostatin M receptor -0.0142306
RPS17 ribosomal protein S17 -0.0141562
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.013967
POMP proteasome maturation protein -0.0138339
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0136648
RPL35 ribosomal protein L35 -0.0135998
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0133949
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0132655
MAP1B microtubule-associated protein 1B -0.0131959
SLC38A2 solute carrier family 38, member 2 -0.0131624
FTH1 ferritin, heavy polypeptide 1 -0.0131546
NAV3 neuron navigator 3 -0.0131454
PRKD1 protein kinase D1 -0.0131186
B2M beta-2-microglobulin -0.0131168
RPS10 ribosomal protein S10 -0.013096
LRP10 low density lipoprotein receptor-related protein 10 -0.0130935
NF1 neurofibromin 1 -0.0130415
RPL27 ribosomal protein L27 -0.0128479
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -0.0128407
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.0127072
S100A9 S100 calcium binding protein A9 -0.0126189
NBEAL1 neurobeachin-like 1 -0.0126185