| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Crizotinib (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Crizotinib (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.123583 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0969495 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0846234 |
| MATR3 | matrin 3 | 0.0840713 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0833318 |
| VIM | vimentin | 0.0814556 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0813226 |
| ZNF292 | zinc finger protein 292 | 0.0796553 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0778494 |
| CANX | calnexin | 0.0743696 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0682677 |
| MYOF | myoferlin | 0.0657811 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0656677 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.065332 |
| TENM1 | teneurin transmembrane protein 1 | 0.0650806 |
| HELZ | helicase with zinc finger | 0.0648692 |
| GOLGA4 | golgin A4 | 0.0646845 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0633219 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.061955 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0613564 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0607353 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0598416 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0592155 |
| FLNB | filamin B, beta | 0.0582561 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0580547 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0579937 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.056635 |
| PDE10A | phosphodiesterase 10A | 0.0564345 |
| FLNA | filamin A, alpha | 0.0560937 |
| RNF145 | ring finger protein 145 | 0.056036 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0532865 |
| PCBP2 | poly(rC) binding protein 2 | 0.0525902 |
| APP | amyloid beta (A4) precursor protein | 0.0524974 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0511387 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0507523 |
| RBM39 | RNA binding motif protein 39 | 0.0503346 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0501939 |
| STC1 | stanniocalcin 1 | 0.0499406 |
| SETD5 | SET domain containing 5 | 0.0497293 |
| QKI | QKI, KH domain containing, RNA binding | 0.0497113 |
| NEK7 | NIMA-related kinase 7 | 0.0485099 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0485031 |
| SQSTM1 | sequestosome 1 | 0.0483888 |
| ATP13A3 | ATPase type 13A3 | 0.0479855 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0477984 |
| RAD21 | RAD21 homolog (S. pombe) | 0.046972 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0465969 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0463098 |
| BRD2 | bromodomain containing 2 | 0.0459898 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0450197 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0444346 |
| RPS19 | ribosomal protein S19 | 0.0442252 |
| RPS6 | ribosomal protein S6 | 0.0440409 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0438965 |
| MORF4L2 | mortality factor 4 like 2 | 0.0431312 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0426233 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0414203 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0398225 |
| NOP58 | NOP58 ribonucleoprotein | 0.0389289 |
| OGA | O-GlcNAcase | 0.0387533 |
| MT2A | metallothionein 2A | 0.0386178 |
| RPL4 | ribosomal protein L4 | 0.0384438 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0382655 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0379712 |
| COL5A2 | collagen, type V, alpha 2 | 0.0379575 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0372628 |
| FMNL2 | formin-like 2 | 0.0371337 |
| RPS16 | ribosomal protein S16 | 0.0371116 |
| CCNL1 | cyclin L1 | 0.0367055 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0366965 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0363972 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0362134 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0359533 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0347449 |
| RBM15 | RNA binding motif protein 15 | 0.0345378 |
| DST | dystonin | 0.0343442 |
| RYBP | RING1 and YY1 binding protein | 0.0343302 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0342825 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0341777 |
| KRT17 | keratin 17, type I | 0.0338824 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0336479 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0333051 |
| SPAG9 | sperm associated antigen 9 | 0.0331167 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0328447 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0326826 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0325622 |
| RPL12 | ribosomal protein L12 | 0.0313841 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0312907 |
| PCM1 | pericentriolar material 1 | 0.0309781 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0308218 |
| RPL23 | ribosomal protein L23 | 0.0304602 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.030147 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0299165 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0298609 |
| ZNF207 | zinc finger protein 207 | 0.0298061 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0297148 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.0296288 |
| IPO7 | importin 7 | 0.0295628 |
| SMAD3 | SMAD family member 3 | 0.0290327 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0287493 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.176865 |
| MYO1E | myosin IE | -0.163289 |
| SLTM | SAFB-like, transcription modulator | -0.118523 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.113996 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0884828 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0877761 |
| EGFR | epidermal growth factor receptor | -0.0835035 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0818184 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0792034 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0777605 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0744757 |
| FN1 | fibronectin 1 | -0.0742093 |
| OSMR | oncostatin M receptor | -0.0701533 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0698987 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0666816 |
| ATOSA | atos homolog A | -0.0647547 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0643132 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0642446 |
| BPTF | bromodomain PHD finger transcription factor | -0.0626733 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0615232 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0611125 |
| POTEF | POTE ankyrin domain family, member F | -0.059646 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0593287 |
| AK1 | adenylate kinase 1 | -0.0563336 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.055717 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.052819 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0495125 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0491478 |
| IGF2 | insulin-like growth factor 2 | -0.0490571 |
| ANXA2 | annexin A2 | -0.0484015 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0463861 |
| VCL | vinculin | -0.0428737 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0423747 |
| RPS8 | ribosomal protein S8 | -0.0418789 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0415845 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0403026 |
| TXNIP | thioredoxin interacting protein | -0.0402913 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0402711 |
| HLA-B | major histocompatibility complex, class I, B | -0.0398988 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0398903 |
| SVIL | supervillin | -0.0398667 |
| GPC6 | glypican 6 | -0.0395388 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0392177 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0384806 |
| RRBP1 | ribosome binding protein 1 | -0.0381015 |
| ASPH | aspartate beta-hydroxylase | -0.0380948 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0380183 |
| PRELID2 | PRELI domain containing 2 | -0.0377725 |
| TMSB10 | thymosin beta 10 | -0.0376781 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0375876 |
| EHBP1 | EH domain binding protein 1 | -0.0372791 |
| RAD51B | RAD51 paralog B | -0.0372493 |
| TPM4 | tropomyosin 4 | -0.0372067 |
| B2M | beta-2-microglobulin | -0.0368702 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0361535 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0359139 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0359021 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0354804 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0354086 |
| MED13L | mediator complex subunit 13-like | -0.0351834 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0342065 |
| MYO9A | myosin IXA | -0.0340082 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0334411 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0331973 |
| RBM25 | RNA binding motif protein 25 | -0.0330266 |
| FBXO11 | F-box protein 11 | -0.0329571 |
| IER3 | immediate early response 3 | -0.0325592 |
| MMP1 | matrix metallopeptidase 1 | -0.0324473 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0319504 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0316504 |
| S100A9 | S100 calcium binding protein A9 | -0.0311105 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0307972 |
| CADM2 | cell adhesion molecule 2 | -0.0307508 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0307248 |
| SP100 | SP100 nuclear antigen | -0.0305602 |
| RPL19 | ribosomal protein L19 | -0.0301473 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0299087 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0297839 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0296498 |
| MUC13 | mucin 13, cell surface associated | -0.0293072 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0292445 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0289328 |
| PKM | pyruvate kinase, muscle | -0.0287583 |
| RPL35A | ribosomal protein L35a | -0.0286185 |
| ATXN1 | ataxin 1 | -0.0285174 |
| SMYD3 | SET and MYND domain containing 3 | -0.0281452 |
| CALD1 | caldesmon 1 | -0.028134 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0281085 |
| MSI2 | musashi RNA-binding protein 2 | -0.0279696 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.027969 |
| CUX1 | cut-like homeobox 1 | -0.0279213 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0278644 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0272099 |
| RPS21 | ribosomal protein S21 | -0.0271873 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0271788 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0268306 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0266643 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0258885 |
| LAMB3 | laminin, beta 3 | -0.0258086 |
| FOXP1 | forkhead box P1 | -0.0256844 |
