Crizotinib (hydrochloride)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Crizotinib (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Crizotinib (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0955938
VIM vimentin 0.0841224
KRT18 keratin 18, type I 0.0694039
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0666527
RPS3 ribosomal protein S3 0.050661
RPS4X ribosomal protein S4, X-linked 0.0504669
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0491682
MYH9 myosin, heavy chain 9, non-muscle 0.0432875
RPS8 ribosomal protein S8 0.0429193
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0414031
HSPA8 heat shock 70kDa protein 8 0.0408435
RPL13A ribosomal protein L13a 0.0390093
EEF2 eukaryotic translation elongation factor 2 0.0381358
PTMA prothymosin, alpha 0.0352861
RPL4 ribosomal protein L4 0.0343311
FLNA filamin A, alpha 0.033675
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0323368
TFPI2 tissue factor pathway inhibitor 2 0.0314322
EEF1G eukaryotic translation elongation factor 1 gamma 0.0311538
MCL1 myeloid cell leukemia 1 0.0305234
RPS17 ribosomal protein S17 0.0303128
AKAP12 A kinase (PRKA) anchor protein 12 0.0293621
RPS27 ribosomal protein S27 0.028763
RPL23 ribosomal protein L23 0.0285651
RPL37 ribosomal protein L37 0.0284407
TPM2 tropomyosin 2 (beta) 0.0284021
RPL37A ribosomal protein L37a 0.0278685
TPT1 tumor protein, translationally-controlled 1 0.0278562
RPS29 ribosomal protein S29 0.027709
RPL12 ribosomal protein L12 0.027325
RPL11 ribosomal protein L11 0.0264362
NACA nascent polypeptide-associated complex alpha subunit 0.0257718
RPS10 ribosomal protein S10 0.0246918
KDM3A lysine (K)-specific demethylase 3A 0.0242547
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0241858
RPL31 ribosomal protein L31 0.0239119
RPS27A ribosomal protein S27a 0.0238548
CEP250 centrosomal protein 250kDa 0.0236835
RPS12 ribosomal protein S12 0.0232528
MYL12B myosin, light chain 12B, regulatory 0.0226278
PGK1 phosphoglycerate kinase 1 0.0226131
RPL35A ribosomal protein L35a 0.0225786
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0220561
YBX1 Y box binding protein 1 0.0218389
RPLP1 ribosomal protein, large, P1 0.0218096
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0209833
EIF1 eukaryotic translation initiation factor 1 0.0208588
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0206156
RPS14 ribosomal protein S14 0.0203845
OGA O-GlcNAcase 0.0203291
RPL7 ribosomal protein L7 0.0203127
RPL19 ribosomal protein L19 0.0196332
PLEC plectin 0.0195319
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.0193783
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0192868
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0192748
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0191317
RPL38 ribosomal protein L38 0.0188759
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0188239
TPM3 tropomyosin 3 0.0187045
RPL3 ribosomal protein L3 0.0185657
UBC ubiquitin C 0.0184738
RSL1D1 ribosomal L1 domain containing 1 0.0183213
RPL26 ribosomal protein L26 0.0180671
FKBP4 FK506 binding protein 4, 59kDa 0.0176875
RPS25 ribosomal protein S25 0.0176345
RPS19 ribosomal protein S19 0.0173997
RACK1 receptor for activated C kinase 1 0.0170173
RPS23 ribosomal protein S23 0.0170127
BRD2 bromodomain containing 2 0.0168028
RPL14 ribosomal protein L14 0.0167522
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0161867
MAGEA4 melanoma antigen family A4 0.016099
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0160647
RPL41 ribosomal protein L41 0.0157395
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0157034
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0156757
NAP1L1 nucleosome assembly protein 1-like 1 0.0156435
NCAPD2 non-SMC condensin I complex, subunit D2 0.0155398
CASC3 cancer susceptibility candidate 3 0.0155228
PDIA4 protein disulfide isomerase family A, member 4 0.0153577
HYOU1 hypoxia up-regulated 1 0.0153422
NUMA1 nuclear mitotic apparatus protein 1 0.0152141
INTS6 integrator complex subunit 6 0.015111
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0145374
RPS6 ribosomal protein S6 0.0144052
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0142863
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0142096
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0142091
EIF4B eukaryotic translation initiation factor 4B 0.0140521
PPME1 protein phosphatase methylesterase 1 0.0140412
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.013979
SERINC1 serine incorporator 1 0.0139212
RTN4 reticulon 4 0.0138363
APLP2 amyloid beta (A4) precursor-like protein 2 0.0138141
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0136978
CAMTA1 calmodulin binding transcription activator 1 0.0136929
ERGIC3 ERGIC and golgi 3 0.013661
RPLP2 ribosomal protein, large, P2 0.0135748
EZR ezrin 0.0135286

decreased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B -0.121886
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.101109
EGR1 early growth response 1 -0.0839061
THSD4 thrombospondin, type I, domain containing 4 -0.0723976
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0707503
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.065631
OSMR oncostatin M receptor -0.0618405
PDE4D phosphodiesterase 4D, cAMP-specific -0.0606147
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0594173
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0557723
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0556271
NF1 neurofibromin 1 -0.0555559
TAS2R14 taste receptor, type 2, member 14 -0.0546301
PTK2 protein tyrosine kinase 2 -0.0522171
HMGA2 high mobility group AT-hook 2 -0.0521609
ZBTB20 zinc finger and BTB domain containing 20 -0.0516496
EML4 echinoderm microtubule associated protein like 4 -0.0508137
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0506794
EXOC4 exocyst complex component 4 -0.0504338
GRAMD1B GRAM domain containing 1B -0.0467574
POTEF POTE ankyrin domain family, member F -0.0465098
PDE10A phosphodiesterase 10A -0.0430589
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0418226
RIMS2 regulating synaptic membrane exocytosis 2 -0.0416307
YBX3 Y box binding protein 3 -0.041619
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0415203
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0398514
EGFR epidermal growth factor receptor -0.039395
SENP6 SUMO1/sentrin specific peptidase 6 -0.03897
AFF3 AF4/FMR2 family, member 3 -0.0387677
NCOA7 nuclear receptor coactivator 7 -0.038561
USP34 ubiquitin specific peptidase 34 -0.0380691
BBX bobby sox homolog (Drosophila) -0.037652
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0374672
BPTF bromodomain PHD finger transcription factor -0.0363305
RICTOR RPTOR independent companion of MTOR, complex 2 -0.03582
WDR70 WD repeat domain 70 -0.0355862
SBF2 SET binding factor 2 -0.0353817
PHF21A PHD finger protein 21A -0.0352658
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0351783
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0350305
TBC1D5 TBC1 domain family, member 5 -0.0348115
ZNF638 zinc finger protein 638 -0.0338205
BABAM2 BRISC and BRCA1 A complex member 2 -0.0327985
ATXN1 ataxin 1 -0.0327609
CCDC91 coiled-coil domain containing 91 -0.0325895
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0324453
BIRC6 baculoviral IAP repeat containing 6 -0.0318995
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0315878
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0309467
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0308307
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0308187
EHBP1 EH domain binding protein 1 -0.0298214
RSF1 remodeling and spacing factor 1 -0.0294095
ZMYND8 zinc finger, MYND-type containing 8 -0.0290244
IGF2 insulin-like growth factor 2 -0.0280469
SLC38A2 solute carrier family 38, member 2 -0.0280175
ATG7 autophagy related 7 -0.0279891
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0279429
BCAS3 breast carcinoma amplified sequence 3 -0.0278311
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0275583
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0273931
DENND5B DENN/MADD domain containing 5B -0.0272642
NIPBL Nipped-B homolog (Drosophila) -0.0264206
KDM2A lysine (K)-specific demethylase 2A -0.0263581
FAF1 Fas (TNFRSF6) associated factor 1 -0.0262509
ZNF292 zinc finger protein 292 -0.0259272
PARD3 par-3 family cell polarity regulator -0.0259174
DNAH14 dynein, axonemal, heavy chain 14 -0.0258662
UBE2H ubiquitin-conjugating enzyme E2H -0.0254917
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0254789
WDPCP WD repeat containing planar cell polarity effector -0.0253174
WWOX WW domain containing oxidoreductase -0.0252923
ZMYM4 zinc finger, MYM-type 4 -0.025106
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0250921
MON2 MON2 homolog (S. cerevisiae) -0.0250787
MAP4 microtubule-associated protein 4 -0.024979
FCHSD2 FCH and double SH3 domains 2 -0.0245812
RYR3 ryanodine receptor 3 -0.0244521
CD2AP CD2-associated protein -0.0243919
THOC2 THO complex 2 -0.0243714
PFN1 profilin 1 -0.0242142
SPIDR scaffolding protein involved in DNA repair -0.0241373
SSH2 slingshot protein phosphatase 2 -0.0240864
ZNF207 zinc finger protein 207 -0.0240428
ARB2A ARB2 cotranscriptional regulator A -0.0240257
RABGAP1L RAB GTPase activating protein 1-like -0.0240064
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0239859
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0239024
FBXO11 F-box protein 11 -0.0234584
PATJ PATJ crumbs cell polarity complex component -0.0234001
TRIO trio Rho guanine nucleotide exchange factor -0.0232436
NBEAL1 neurobeachin-like 1 -0.0232115
IGF1R insulin-like growth factor 1 receptor -0.0231166
SRBD1 S1 RNA binding domain 1 -0.0227823
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0226599
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0226395
THADA thyroid adenoma associated -0.022479
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0223822
MMP12 matrix metallopeptidase 12 -0.0221753