| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Crizotinib (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Crizotinib (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.170479 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.107786 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0987362 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.097631 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0897589 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0753714 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0730661 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0609394 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0574348 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0550765 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0523668 |
| CANX | calnexin | 0.0510603 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0505797 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0456291 |
| FLNA | filamin A, alpha | 0.044273 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0439848 |
| KRT18 | keratin 18, type I | 0.0433638 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0409521 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.040149 |
| ASPH | aspartate beta-hydroxylase | 0.0392867 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0388977 |
| HMGB2 | high mobility group box 2 | 0.0382438 |
| CALR | calreticulin | 0.0374246 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0368894 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0367218 |
| ARRDC3 | arrestin domain containing 3 | 0.035655 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0348882 |
| LAMC2 | laminin, gamma 2 | 0.0338515 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0320935 |
| RPL4 | ribosomal protein L4 | 0.0303252 |
| PLEC | plectin | 0.0302016 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0297268 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0270378 |
| MYO5B | myosin VB | 0.0265555 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0264941 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0260024 |
| IRF6 | interferon regulatory factor 6 | 0.0255974 |
| G0S2 | G0/G1 switch 2 | 0.0245813 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0244199 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0241036 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0235599 |
| RPL7 | ribosomal protein L7 | 0.0233977 |
| RPL14 | ribosomal protein L14 | 0.0232484 |
| LDHA | lactate dehydrogenase A | 0.0226083 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0224718 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0222361 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0220619 |
| FAM13A | family with sequence similarity 13, member A | 0.0220413 |
| YTHDC1 | YTH domain containing 1 | 0.0211111 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0210071 |
| RYBP | RING1 and YY1 binding protein | 0.020541 |
| TFG | TRK-fused gene | 0.020384 |
| APP | amyloid beta (A4) precursor protein | 0.0202388 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0199963 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0198213 |
| EZR | ezrin | 0.019617 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0195671 |
| CCNL1 | cyclin L1 | 0.0190485 |
| NUP58 | nucleoporin 58 | 0.0185862 |
| RPS4X | ribosomal protein S4, X-linked | 0.0185737 |
| RAP2B | RAP2B, member of RAS oncogene family | 0.0184234 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0184076 |
| PCBP2 | poly(rC) binding protein 2 | 0.0183289 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.018204 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0181063 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0176244 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.017515 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0168305 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0164275 |
| SPAG5 | sperm associated antigen 5 | 0.0163789 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0163309 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0163246 |
| VEGFA | vascular endothelial growth factor A | 0.0162702 |
| PLAU | plasminogen activator, urokinase | 0.0161664 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0160135 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0159946 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0159798 |
| ANXA1 | annexin A1 | 0.0158948 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0158268 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0157576 |
| RPL3 | ribosomal protein L3 | 0.0156664 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0153288 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0152918 |
| MSN | moesin | 0.0152047 |
| USP3 | ubiquitin specific peptidase 3 | 0.0150276 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0148407 |
| PAPOLA | poly(A) polymerase alpha | 0.0147892 |
| ZNF292 | zinc finger protein 292 | 0.0147133 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0146451 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0146039 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.014397 |
| SQLE | squalene epoxidase | 0.0142602 |
| RLF | rearranged L-myc fusion | 0.0142332 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0141856 |
| RNF145 | ring finger protein 145 | 0.0141831 |
| EMP1 | epithelial membrane protein 1 | 0.0141426 |
| ANXA11 | annexin A11 | 0.0141187 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0141128 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0141119 |
| SNX9 | sorting nexin 9 | 0.0140761 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.238076 |
| ACTG1 | actin gamma 1 | -0.233494 |
| TMSB10 | thymosin beta 10 | -0.180655 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.148533 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.127638 |
| FTL | ferritin, light polypeptide | -0.119964 |
| PTMA | prothymosin, alpha | -0.112679 |
| RPL35A | ribosomal protein L35a | -0.0993626 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.098017 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0957793 |
| POTEF | POTE ankyrin domain family, member F | -0.0893294 |
| FBXO32 | F-box protein 32 | -0.0880826 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0839408 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0777465 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0744694 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0681221 |
| RPLP1 | ribosomal protein, large, P1 | -0.0646376 |
| S100A10 | S100 calcium binding protein A10 | -0.0644075 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.06412 |
| RPL34 | ribosomal protein L34 | -0.0639035 |
| HLA-B | major histocompatibility complex, class I, B | -0.0638991 |
| S100A6 | S100 calcium binding protein A6 | -0.0602801 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0583194 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0552469 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0547071 |
| RPLP2 | ribosomal protein, large, P2 | -0.0522915 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0520981 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0507937 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0498379 |
| ERBIN | erbb2 interacting protein | -0.049456 |
| S100A9 | S100 calcium binding protein A9 | -0.0493983 |
| RPS29 | ribosomal protein S29 | -0.0476675 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0473881 |
| CD2AP | CD2-associated protein | -0.0467674 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0465917 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0464704 |
| RPS13 | ribosomal protein S13 | -0.0463554 |
| MT2A | metallothionein 2A | -0.045606 |
| RPL8 | ribosomal protein L8 | -0.0455291 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0453226 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0452758 |
| RPS19 | ribosomal protein S19 | -0.0452635 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0430541 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0428002 |
| MAP1B | microtubule-associated protein 1B | -0.0425628 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0420938 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0412355 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0411326 |
| CSTB | cystatin B (stefin B) | -0.0410832 |
| EFNA5 | ephrin-A5 | -0.0409102 |
| RPS6 | ribosomal protein S6 | -0.0406083 |
| RPS23 | ribosomal protein S23 | -0.0404407 |
| RPS21 | ribosomal protein S21 | -0.0399212 |
| RPS8 | ribosomal protein S8 | -0.0396717 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.039515 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0394138 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0391812 |
| NF1 | neurofibromin 1 | -0.0378286 |
| MX2 | MX dynamin-like GTPase 2 | -0.0375398 |
| NDRG1 | N-myc downstream regulated 1 | -0.037155 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0369956 |
| CCND1 | cyclin D1 | -0.0363978 |
| MAP4 | microtubule-associated protein 4 | -0.0361763 |
| HLA-A | major histocompatibility complex, class I, A | -0.0351348 |
| MYO1E | myosin IE | -0.0346506 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0342428 |
| TMEM165 | transmembrane protein 165 | -0.033963 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0332199 |
| KRT7 | keratin 7, type II | -0.033163 |
| TPM4 | tropomyosin 4 | -0.0329072 |
| RAD51B | RAD51 paralog B | -0.0328021 |
| RNF213 | ring finger protein 213 | -0.0320587 |
| RBM47 | RNA binding motif protein 47 | -0.0319763 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0318842 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0316802 |
| RPL9 | ribosomal protein L9 | -0.031301 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0310392 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0308816 |
| RPL28 | ribosomal protein L28 | -0.0304796 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0303562 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.030351 |
| RPL32 | ribosomal protein L32 | -0.030138 |
| RPS15 | ribosomal protein S15 | -0.0299129 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0292613 |
| RASAL2 | RAS protein activator like 2 | -0.0291585 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0290674 |
| TXNIP | thioredoxin interacting protein | -0.0287399 |
| FRMD5 | FERM domain containing 5 | -0.0285596 |
| RAI14 | retinoic acid induced 14 | -0.0283599 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0282781 |
| GOLGB1 | golgin B1 | -0.0279811 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.02798 |
| RBM25 | RNA binding motif protein 25 | -0.0279521 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0278625 |
| SNX6 | sorting nexin 6 | -0.0275488 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0272918 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0268393 |
| AHNAK | AHNAK nucleoprotein | -0.0267578 |
| BPTF | bromodomain PHD finger transcription factor | -0.026613 |
| RPL31 | ribosomal protein L31 | -0.0264835 |
