| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Crizotinib (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Crizotinib (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.149459 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.133494 |
| NUP58 | nucleoporin 58 | 0.121349 |
| SPAG9 | sperm associated antigen 9 | 0.118331 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.114713 |
| RPS16 | ribosomal protein S16 | 0.114496 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.111253 |
| FTL | ferritin, light polypeptide | 0.0961652 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0944576 |
| CDC73 | cell division cycle 73 | 0.0941368 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0897027 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0890693 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0864308 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0843028 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0831448 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0828083 |
| RPS3 | ribosomal protein S3 | 0.0825037 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0803131 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0801916 |
| MT2A | metallothionein 2A | 0.0784008 |
| PTMA | prothymosin, alpha | 0.0778575 |
| USP3 | ubiquitin specific peptidase 3 | 0.0777016 |
| SETD5 | SET domain containing 5 | 0.0771717 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0767358 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0723933 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0720091 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0701331 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0701079 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0692297 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0689928 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0671178 |
| MEF2A | myocyte enhancer factor 2A | 0.0662423 |
| RTN4 | reticulon 4 | 0.0638129 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0630162 |
| RYBP | RING1 and YY1 binding protein | 0.0615339 |
| RPL11 | ribosomal protein L11 | 0.0611262 |
| H3-3B | H3.3 histone B | 0.0604329 |
| GOLGA4 | golgin A4 | 0.0603443 |
| RLF | rearranged L-myc fusion | 0.0597685 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0573223 |
| MATR3 | matrin 3 | 0.0562832 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0547357 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0539698 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0521492 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0520632 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0505028 |
| PGK1 | phosphoglycerate kinase 1 | 0.0502028 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0477008 |
| MSN | moesin | 0.0464182 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0443631 |
| RPLP1 | ribosomal protein, large, P1 | 0.0438569 |
| PDE10A | phosphodiesterase 10A | 0.043154 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0430507 |
| RPL12 | ribosomal protein L12 | 0.0424595 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0418982 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0411661 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0404723 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0382937 |
| OGA | O-GlcNAcase | 0.037673 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0342425 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0327867 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0321471 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0316984 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0310054 |
| RPS4X | ribosomal protein S4, X-linked | 0.0307713 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0303372 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0286071 |
| RPS12 | ribosomal protein S12 | 0.0285218 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0281147 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0262058 |
| VMP1 | vacuole membrane protein 1 | 0.0261523 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0260764 |
| ZNF292 | zinc finger protein 292 | 0.0259567 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0254493 |
| MSI2 | musashi RNA-binding protein 2 | 0.0241342 |
| RPL23 | ribosomal protein L23 | 0.0230994 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0229811 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0227785 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0215824 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0212868 |
| RPS6 | ribosomal protein S6 | 0.0210488 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0190445 |
| ENO1 | enolase 1, (alpha) | 0.0179084 |
| FMNL2 | formin-like 2 | 0.0177098 |
| TMF1 | TATA element modulatory factor 1 | 0.017683 |
| SMYD3 | SET and MYND domain containing 3 | 0.0166128 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0163982 |
| PKM | pyruvate kinase, muscle | 0.0149045 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0143925 |
| SLTM | SAFB-like, transcription modulator | 0.0139167 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0126708 |
| CANX | calnexin | 0.0114339 |
| SQSTM1 | sequestosome 1 | 0.0108941 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.00986411 |
| PTK2 | protein tyrosine kinase 2 | 0.00845948 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.007814 |
| LDHA | lactate dehydrogenase A | 0.00716088 |
| DST | dystonin | 0.00508446 |
| RPL37 | ribosomal protein L37 | 0.00496197 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.00334535 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.144866 |
| PRKCA | protein kinase C, alpha | -0.133539 |
| FN1 | fibronectin 1 | -0.12306 |
| COL5A2 | collagen, type V, alpha 2 | -0.115477 |
| GPC6 | glypican 6 | -0.111268 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.110559 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.105061 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.104997 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0993337 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0928349 |
| EFNA5 | ephrin-A5 | -0.0869978 |
| IGF2 | insulin-like growth factor 2 | -0.08693 |
| RNF213 | ring finger protein 213 | -0.0865213 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0853728 |
| RIGI | RNA sensor RIG-I | -0.0829431 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.078869 |
| RUNX1 | runt-related transcription factor 1 | -0.0757208 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0755693 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0707313 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0700766 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0657155 |
| EGFR | epidermal growth factor receptor | -0.0649094 |
| ASPH | aspartate beta-hydroxylase | -0.0634188 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0631263 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0625475 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0621846 |
| NFIA | nuclear factor I/A | -0.0606673 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0603968 |
| MYO1E | myosin IE | -0.0599837 |
| BMERB1 | bMERB domain containing 1 | -0.0590977 |
| LMO7 | LIM domain 7 | -0.0583136 |
| PRELID2 | PRELI domain containing 2 | -0.0575613 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0572978 |
| FRMD5 | FERM domain containing 5 | -0.0568164 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0553923 |
| FHIT | fragile histidine triad | -0.0547716 |
| NABP1 | nucleic acid binding protein 1 | -0.0538004 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0534166 |
| RAD51B | RAD51 paralog B | -0.0517848 |
| TENM3 | teneurin transmembrane protein 3 | -0.0517096 |
| NF1 | neurofibromin 1 | -0.0510568 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0509094 |
| GLIS3 | GLIS family zinc finger 3 | -0.0503893 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0499635 |
| YAP1 | Yes-associated protein 1 | -0.0497679 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0479951 |
| FOXP1 | forkhead box P1 | -0.047823 |
| CNKSR3 | CNKSR family member 3 | -0.046479 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0454087 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0453017 |
| HMGA2 | high mobility group AT-hook 2 | -0.0444738 |
| EGR1 | early growth response 1 | -0.04426 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0439901 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0432833 |
| JMJD1C | jumonji domain containing 1C | -0.0413954 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0408545 |
| MCL1 | myeloid cell leukemia 1 | -0.0404999 |
| SBF2 | SET binding factor 2 | -0.040272 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0402111 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0400171 |
| LAMA4 | laminin, alpha 4 | -0.0396251 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0394074 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0385382 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0382525 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0381631 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0359666 |
| STK24 | serine/threonine kinase 24 | -0.0357565 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0353417 |
| NPAS2 | neuronal PAS domain protein 2 | -0.035299 |
| CALU | calumenin | -0.034874 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0346942 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.034642 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0325342 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0312459 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0308186 |
| FAM107B | family with sequence similarity 107, member B | -0.0302146 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0296929 |
| ANO6 | anoctamin 6 | -0.0291414 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0281407 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0279935 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0270774 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0269704 |
| PARD3 | par-3 family cell polarity regulator | -0.02694 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0265962 |
| ATXN1 | ataxin 1 | -0.0263455 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0262858 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0261528 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0258418 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0245528 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0244462 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.024344 |
| USP34 | ubiquitin specific peptidase 34 | -0.0238896 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0224053 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0210956 |
| RAB10 | RAB10, member RAS oncogene family | -0.0209708 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0208129 |
| SLC38A1 | solute carrier family 38, member 1 | -0.020136 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0199964 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0193641 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0193317 |
