| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Crizotinib (hydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Crizotinib (hydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.249656 |
| VIM | vimentin | 0.189766 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0949256 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0928628 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0894516 |
| RPS16 | ribosomal protein S16 | 0.0747754 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0687534 |
| FBL | fibrillarin | 0.0544271 |
| ARRDC3 | arrestin domain containing 3 | 0.0534792 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0515981 |
| ACTN4 | actinin, alpha 4 | 0.0446215 |
| TXNRD1 | thioredoxin reductase 1 | 0.0383079 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0352151 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 0.0346609 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0333632 |
| SFTPA2 | surfactant protein A2 | 0.0319641 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0319519 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0316275 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.031037 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0298114 |
| TMEM41B | transmembrane protein 41B | 0.0297604 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0286224 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0279921 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0274563 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.025372 |
| SMAD3 | SMAD family member 3 | 0.0247966 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | 0.0244155 |
| OGA | O-GlcNAcase | 0.0241653 |
| RPL7 | ribosomal protein L7 | 0.0241063 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0237755 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0234731 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0233558 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0231493 |
| YBX1 | Y box binding protein 1 | 0.0231432 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0229606 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0224653 |
| CANX | calnexin | 0.0222608 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0216488 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.021637 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0213269 |
| PLEC | plectin | 0.0204237 |
| RPL4 | ribosomal protein L4 | 0.0201884 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0195598 |
| HYOU1 | hypoxia up-regulated 1 | 0.0193335 |
| UBC | ubiquitin C | 0.0192297 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.019198 |
| SEPTIN9 | septin 9 | 0.0189539 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0179299 |
| PLEKHG2 | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | 0.0178043 |
| SQSTM1 | sequestosome 1 | 0.017766 |
| L1CAM | L1 cell adhesion molecule | 0.0175546 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0174517 |
| RPS4X | ribosomal protein S4, X-linked | 0.0169682 |
| ZNF146 | zinc finger protein 146 | 0.0168949 |
| FDPS | farnesyl diphosphate synthase | 0.0167037 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0165862 |
| DSTN | destrin (actin depolymerizing factor) | 0.0158843 |
| PCBP2 | poly(rC) binding protein 2 | 0.0155738 |
| APP | amyloid beta (A4) precursor protein | 0.01553 |
| SERINC1 | serine incorporator 1 | 0.0153054 |
| FOSL1 | FOS-like antigen 1 | 0.0151038 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0150806 |
| TPD52 | tumor protein D52 | 0.0150355 |
| ANXA2 | annexin A2 | 0.0150355 |
| S100A6 | S100 calcium binding protein A6 | 0.0149853 |
| ATF4 | activating transcription factor 4 | 0.0149089 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0148168 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0148088 |
| RPL3 | ribosomal protein L3 | 0.0147465 |
| IPO7 | importin 7 | 0.0145936 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0144417 |
| CASC3 | cancer susceptibility candidate 3 | 0.0144146 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0140991 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0139372 |
| PHF3 | PHD finger protein 3 | 0.0137605 |
| MATR3 | matrin 3 | 0.0136552 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0136472 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0135939 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.013568 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0135468 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0134992 |
| ANGPTL4 | angiopoietin-like 4 | 0.0131673 |
| SQLE | squalene epoxidase | 0.013129 |
| KLHL24 | kelch-like family member 24 | 0.0131248 |
| GPBP1L1 | GC-rich promoter binding protein 1-like 1 | 0.0130798 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0130736 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0130496 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0129425 |
| AXL | AXL receptor tyrosine kinase | 0.0129021 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.012755 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0125682 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0125187 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 0.0123592 |
| SET | SET nuclear proto-oncogene | 0.0123269 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0122069 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0121964 |
| NUP58 | nucleoporin 58 | 0.0121582 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0121337 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.011919 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.0119074 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.188679 |
| VCL | vinculin | -0.135552 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.119577 |
| PTMA | prothymosin, alpha | -0.107334 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.103517 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0950617 |
| TMSB10 | thymosin beta 10 | -0.0938203 |
| DST | dystonin | -0.0800206 |
| AHNAK | AHNAK nucleoprotein | -0.0767457 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0748478 |
| PTK2 | protein tyrosine kinase 2 | -0.0735195 |
| HMGA2 | high mobility group AT-hook 2 | -0.0696991 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0645392 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0640547 |
| ACTG1 | actin gamma 1 | -0.055229 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0551615 |
| EGR1 | early growth response 1 | -0.0519769 |
| RPL35A | ribosomal protein L35a | -0.0512145 |
| NAV2 | neuron navigator 2 | -0.0493566 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0479885 |
| NF1 | neurofibromin 1 | -0.0474794 |
| TNS3 | tensin 3 | -0.0472169 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0464934 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0462471 |
| MT2A | metallothionein 2A | -0.045428 |
| ATG7 | autophagy related 7 | -0.0454116 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0453493 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0453322 |
| RNF220 | ring finger protein 220 | -0.0452817 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.044496 |
| DIAPH2 | diaphanous-related formin 2 | -0.0442562 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0426896 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0420172 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0419104 |
| CARD18 | caspase recruitment domain family, member 18 | -0.0417003 |
| EXOC4 | exocyst complex component 4 | -0.0398137 |
| ZNF780B | zinc finger protein 780B | -0.039535 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0391809 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0390476 |
| RPS24 | ribosomal protein S24 | -0.0384445 |
| EHBP1 | EH domain binding protein 1 | -0.0371456 |
| RAD51B | RAD51 paralog B | -0.0369117 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0360447 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0348977 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0346122 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0339321 |
| SBF2 | SET binding factor 2 | -0.0333749 |
| CTSD | cathepsin D | -0.0332867 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0328305 |
| TCF12 | transcription factor 12 | -0.0325687 |
| NUP98 | nucleoporin 98kDa | -0.0325278 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0323595 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0323337 |
| RIGI | RNA sensor RIG-I | -0.031952 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.031847 |
| CD44 | CD44 molecule (Indian blood group) | -0.031825 |
| THOC2 | THO complex 2 | -0.0318244 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0317493 |
| PHF14 | PHD finger protein 14 | -0.0315817 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0315271 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0312883 |
| RASAL2 | RAS protein activator like 2 | -0.0312461 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0308321 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0307339 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0306256 |
| MYO1E | myosin IE | -0.0306126 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.029796 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0295775 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0294933 |
| ZNF407 | zinc finger protein 407 | -0.0292283 |
| HMGB1 | high mobility group box 1 | -0.0290747 |
| MYO10 | myosin X | -0.0288045 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0283324 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0277903 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0277237 |
| UBAP2 | ubiquitin associated protein 2 | -0.0273089 |
| NHSL1 | NHS-like 1 | -0.0273002 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.027142 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0268767 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0268165 |
| INTS6 | integrator complex subunit 6 | -0.026807 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0265796 |
| RPLP2 | ribosomal protein, large, P2 | -0.026554 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0265243 |
| TPM1 | tropomyosin 1 (alpha) | -0.0262033 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0253978 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0250586 |
| FUS | FUS RNA binding protein | -0.0250367 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0249129 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0247832 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0246871 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0244516 |
| FMNL2 | formin-like 2 | -0.0244507 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0243896 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0239525 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0237914 |
| COMMD10 | COMM domain containing 10 | -0.0237668 |
| CDK6 | cyclin-dependent kinase 6 | -0.0237386 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0236455 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.023602 |
